Polymeric materials have an important role in gluing technology due to their broad application in the wood industry, metal industry, glass, and ceramics industry as well as medicine. This article discusses the basic physicochemical aspects of bonding with adhesives and also, the mechanisms of action of the adhesive materials during bonding based on polymerization processes and different types of polymerization. It was emphasized that depending on the material used in gluing, various adhesives with different physicochemical characteristics facilitate and contribute to the quality of the bonded joints. In this way, it is an insured procedure that is suitable for materials that are sensitive to the effects of heat, because welding and soldering would deform the base material and often the total degradation of its mechanical properties.

: Antigenotoxic and Antioxidative activites of Curcumin Modern biomedical science has proven beneficial effects of curcumin as potential therapeutic candidate for various conditions due to its pleiotropic and pharmacological properties. The aim of the present study was to investigate antigenotoxic effects of curcumin against cisplatin induced genotoxicity as well as its antioxidative effects. In vitro cytokinesis block micronuclei assay in human lymphocytes was used for evaluation of antigenotoxic properties of curcumin. Evaluation of antioxidative properties of curcumin was determined with 2,2-Diphenyl-1-picrylhydrazyl free radical scavenging assay. Results demonstrated significant antigenotoxic and antioxidative properties of curcumin, dependent upon the tested concentrations. Consideration should be given to performing a study with broad dose interval of tested substances. Findings from the present study emphasized application of curcumin as potential antigenotoxic and antioxidative supplementary agent.

The content of macro- and microelements in dry samples of mushrooms of the species Macrolepiota procera, Boletus edulis and Cantharellus cibarius, collected at different areas in Bosnia and Herzegovina, was determined using the ICP-OES method (inductively coupled plasma optical emission spectrometry). Of the macroelements, K is the most represented, followed by S, P, Mg, and the least represented Ca and Na. Zn is the most represented of the essential microelements, followed by Fe, Se, Cu, Mn and Co. Al is the most abundant of the other trace elements followed by Ni and Cr. Of the toxic metals, the most represented is Cd, followed by Pb and As. There are differences in the concentration of micro- and macroelements in the mushrooms analysed, depending on the area from which they were collected because natural geology and geochemistry influence the content of macro- and microelements in wild edible mushrooms. The results show that the analysed mushrooms can be considered a good source of essential elements. The study also assessed potential health risks of heavy metals and the target hazard quotient (THQ) for As, Cd, Pb, Cu, Zn, Ni and Cr in the analysed mushrooms was lower than the safe level. The carcinogenic risk index revealed that Cd and Ni are the most prevalent pollutants in the mushrooms studied.  

Four 4-hydroxycoumarin derivatives were synthesized and the structure was confirmed by NMR spectroscopy and Mass spectrometry. Tested compounds have shown significant antimicrobial activity against Bacillus subtilis subsp. spizizenii, Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis, and the effect of more halogens on the benzene nucleus, as well as the combination of halogen and alkyl groups, on the antimicrobial activity, was investigated. According to the docking study, these compounds can operate simultaneously on two enzymes, amylase and gyrase (1BAG and 1KZN), which are known to play an important role in bacterial life. Obtained docking study parameters for tested compounds showed an association with the in vitro results of the antimicrobial activity of these compounds. In silico tests of molecular properties of the tested compounds showed that the compounds met Lipinski's rule of five. In this paper, the ADME parameters of tested compounds were also calculated: Caco2 (in vitro Caco2 cell permeability), HIA (human intestinal absorption), MDCK (in vitro Mandin Darby Canine Kidney (MDCK) cell permeability), TPSA (topological polar surface area), etc.