There are several theoretical models proposing dark matter candidates as well as different experimental searches for dark matter, collider, and non-collider ones. One of the most intriguing dark matter candidates is missing information in the cosmos. This is based on the mass-energy-information equivalence principle presented by M Vopson [1]. This review presents the historical development of this principle from its roots in the 1960s when Landauer principle was firstly presented to the latest data on the estimated value of the mass of one bit of information as well as data on missing energy as potential dark matter. Another theoretical discussion presented here is the reformulation of the second law of thermodynamics as a possible step to great unification. In addition to this theoretical postulation with a mathematical presentation focusing on statistics, we present some of the proposed experiments in this field. Two major proposals are in the direction of using an ultra-accurate balance with measurement uncertainty low enough to be comparable with proposed theoretical limits, and originally developed sensitive interferometer similar to the one in LIGO experiment.

Dark matter as one of the cosmos’ ingredients or constituents has been searched for in various experiments. This review presents some of the searches for dark matter while focusing on the LHC mainly. In order to present various searches, it describes theoretical models followed by experimental verification. Since there are three types of searches, among which most significant are direct and indirect ones, we will give an overview and short comparison between the two, with an emphasis on the advantages and disadvantages of collider and non-collider searches. This review brings an argumentative approach for the collider’s point of view since searches for dark matter in colliders are veritably ambitious regarding direct and indirect Dark Matter detection methods. LHC starts its Run 3 in 2021, and here we present results from the ATLAS experiment from Run 2 and bring some theoretical expectations from LHC in Run 3.

The present review paper provides a systematic insight into the studies published so far when it comes to the research on the cost and performance optimisation in the parcel delivery phase. Globalisation, as well as the new trends, such as selling online, directly influences the demands for the delivery of goods. Demand for the delivery of goods proportionally affects the transport prices. A great majority of deliveries is carried out in densely populated urban areas. In terms of costs, the greatest part in the courier organisations costs is observed in the technological phase of parcel delivery, which is at the same time the least efficient. For that reason, significant improvement of performance and cost optimisation in the very delivery phase is a rather challenging field for the researchers. New algorithm-based technologies, innovations in the logistics and outsourcing of individual technological phases are ways by means of which one strives to enhance the delivery efficiency, to improve performance and quality, but also to optimise the costs in the last phase of delivery. The aim of the present paper is to offer a systematic review into the most recent research in the field of technology, innovations and outsourcing models with the aim of reducing the cost and enhancing the productivity and quality in parcel delivery.

Objectives: To avoid hospital spread of Coronavirus-2019 (COVID-19) and to analyze out of hospital outcomes after amputation. Methods: Prospective analysis of data obtained from 60 diabetic patients in 2020 was performed at Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina. Personal protection equipment included double surgical mask, glasses, disposable surgical coats, and surgical masks for patients. Swabs were used to take samples from wounds. We randomly divided patients in 2 groups of 30 patients each. In pre-operative treatment, we used local anesthesia lidocaine hydrochloride 2% (Belupo, Koprivnica, Croatia) in group A and systemic analgesia intravenous tramadol chloride 100 mg intravenous (Krka, Novo Mesto, Slovenia) in group B. Wounds were surgically treated each day and heal spontaneously. Periodical control exams were performed. Results: Wound healing did not present any statistically significant differences between groups (group A: 69±21.97 and B: 61±22.13 days, t=−1.22; p=0.11). No statistically significant differences (p<0.05) between groups A and B in wound healing regarding to gender or cigarette use was noted. Conclusion: No significant differences in amputation treatment between the 2 comparative groups were noted. No confirmed COVID-19 infections in medical staff who performed surgical interventions or in treated patients were detected.

Based on the computed tomography (CT) images it is not possible to see all the lymph nodes that belong to the stomach. In radiotherapy, for a clinical target volume (CTV) delineation based on CT images, it is necessary to determine the appropriate margin around the corresponding blood vessels to make sure that all the required lymph nodes will be irradiated. The larger margin will certainly cover all the lymph nodes but it can also produce an increase of the received dose in the normal tissues. While a smaller margin can eventually spare the normal structures as a consequence it brings a higher risk of missing the suspected lymph nodes. The aim of this study was to analyse the radiation doses received by some organs at risk (OARs) in the case of the three-dimensional conformal radiotherapy (3DCRT) treatment of the gastric cancer, for lymph node CTV margin sizes 5 mm, 7 mm and 10 mm. The study included 40 patients undergo the external beam radiotherapy (EBRT) treatment of gastric cancer. The one-way analysis of variance (ANOVA) with repeated measures test and Friedman’s nonparametric test have been used for testing the statistical significance of differences among the examined groups. The difference between the examined groups has been considered significant if p < 0.05. The statistically significant differences in the dose contributions to the observed OARs (spinal cord, heart, small bowel and colon), among the examined CTVs, were found.

This research aimed to determine the differences between the junior (U20) water polo players of national teams of Montenegro, and Australia regarding their anthropometric characteristics and body composition. The first sub-sample of the subjects consisted of 18 water polo players of the Montenegrin national team, who occupied the sixth position on the FINA World Men’s Junior Water Polo Championship in Kuwait 2019. The second sub-sample consisted of 13 water polo players of the Australian national team, who occupied the eleventh position on the championship. The players were tested at the final preparations just before the World Championship. Anthropometric characteristics were evaluated using a battery of eight tests: body height, body weight, triceps skinfold, biceps skinfold, skinfold of the back, abdominal skinfold, upper-leg skinfold, lower leg skinfold; body composition was evaluated using a battery of three tests: body mass index, fat percentage, and muscle mass. The results of the t-test revealed that the water polo players of the two national teams do not have statistically significant differences in the variables. The results obtained in this research showed average team values for the estimated variables of water polo players of the two national teams (U20) who participated in the World Championship. That can serve as possible model parameters for all teams who want to participate in the U20 water polo World Championship. Differences in classification among water polo players may be related to the motor abilities, as well as technical and tactical parameters, as their anthropometric parameters were found to be similar.

Abstract Nanoparticle materials have become a promising candidate for a new kind of storage media based on thermally induced memory effects due to the possibility to tailor their magnetic properties and behaviour. In this study, we have investigated whether the magnetic memory effects could appear at high, industry accessible temperatures including the possibility of thermal data inscription. Investigated iron oxide nanoparticles were synthesized by poliol method, which has been modified in order to allow control of particle agglomeration and consequently magnetic properties. Structure, morphology and the degree of nanoparticle agglomeration were studied by X-Ray diffraction, Transmission Electron Microscopy and Dynamic Light Scattering techniques, while magnetic properties as well as memory effects were measured on a commercial SQUID-based magnetometer. Results of the study confirmed that in super spin glass magnetite nanoparticles, magnetic memory effects can be observed up to 200 K which represents much higher temperatures in comparison to those achieved in spin glasses and other glassy materials. Procedures of writing and reading (inscribing and retrieving) of digital information in such a material were demonstrated and discussed in details.

Hip osteoarthritis (HOA) is characterized by degradation of the cartilage and synovitis. However, the pathohistological effects of synovial tissue inflammation on HOA are not clear. The aim of this study was to evaluate the expression of iNOS, BCL-2 and MMP-9 markers in different synovial cell populations. A total of 32 patients were evaluated retrospectively. Age, sex, height, weight, body mass index were recorded and lymphocyte, fibrocytes and macrophages were analysed in tissue sections. Osteoarthritis cartilage histopathology assessment system (OARSI), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Krenn score, Harris Hip Score (HHS) and Kellgren–Lawrence (K-L) grading of the hip joints were performed. Total hip arthroplasty was performed on 32 patients and controls. Patients were divided into two groups according to their disease severity. The tissues were immunohistochemically analysed. K-L grade and Krenn score differ between all three groups, but also between moderate and severe OA. Synovial lining cell layer, resident cells in stroma and especially inflammatory infiltration were increasing with severity of OA. iNOS expression in both intima and subintima was positively correlated with Krenn score in moderate and severe osteoarthritis (OA) groups. Expression of BCL-2 in intima of severe OA patients was positively correlated with Krenn score. In conclusion, iNOS, BCL-2 and MMP-9 are involved in the regulation of HOA. Our study indicates a relationship between the pathohistological features, the synovial inflammation and the cartilage condition at the time of hip replacement due to OA or femoral neck fracture.

Abstract In contemporary Bosnia and Herzegovina, rural poverty is an unresolved issue, despite farming having been a poverty coping strategy for many rural dwellers, especially after the end of the Balkan war. Eradicating poverty is among the priorities of the national government that aims at EU candidacy and accession. Being the most dynamic among agricultural sectors, berry farming is a key agricultural activity at the national level and had been the subject of rural development interventions, including the establishment of agricultural cooperatives. This article provides evidence from the largest agricultural cooperative in Bosnia and Herzegovina, to inform decision making and policy planning. The article aims at describing and analyzing the status and dynamics of poverty at the farm household level while highlighting their contributing factors, as well as at proposing possible development strategies based on the voice of local actors. Given the complexity and multifaceted features of the investigated issues, the methodological approach of this study relies on a mixed-methods research design, where the quantitative findings from the analysis of poverty status and dynamics and their contributing factors are complemented by qualitative findings from participatory activities. The results of the study pinpoint the successful contribution of the cooperative to the improvement of farmers' working conditions and market access and suggest that supporting collective action among berry farmers can be an effective rural development intervention to alleviate rural poverty and prevent poverty fallouts. To date, structural characteristics of farm holdings and households and climate and market-related conditions have significantly contributed to the farmers' poverty as well as to farmers’ exposure to poverty. Furthermore, bridging the gender gap is still a challenge in Bosnia and Herzegovina which should be addressed urgently to mitigate the problem of social exclusion and to promote bottom-up innovation.

The presence of a high-density material object such as the vascular access port made of titanium, can affect the homogeneity of dose distribution in underlying tissues. This influence depends on numerous factors but in the first place on the composition material of such an object and its geometry. In this work an influence of the various titanium-made vascular ports, placed in the 6 MV photon field, have been analyzed. The vascular ports of various sizes were placed on the top of thepolymethyl-methacrylate (PMMA) phantom which is then scanned on a computed tomography (CT) simulator to generate the digitized 3-dimensional images for the purpose of treatment planning. The treatment plans were prepared in matRad treatment planning toolkit. The beam profiles and the percentage depth doses have been analyzed. The observed maximum dose values, for ports A, B, C and D, relatively to the maximum dose value in PMMA phantom alone, were 102.25%, 100.62%, 101.78% and 102.48%, respectively. The titanium edges of the ports reduce the dose below them in amount of 8.52%, 8.64%, 10.01% and 10.04% observed for ports A, B, C and D, respectively, in comparison to the central axis dose value obtained in PMMA phantom for the port-free case. The established changes in PDD curves and beam profiles depend on the vascular access port dimensions, reservoir volumes as well as of the amount of titanium content.

EMDR is a psychotherapeutic intervention that is based on the reprocessing and desensitization of symptoms related to traumatic stress experiences during bilateral stimulation (Shapiro 1995). According to Carrere (2013), approximately 150 000 clinicians have been trained in EMDR within the worldwide since 1995. EMDR training as a practitioner is traditionally organized in a two-level model, which consists of basic training completed in few days of training and supervision training with a minimum period of 20 hours after completion of basic EMDR training (Shapiro 1995). The two components of training do not overlap and there should be a minimum period of 1 year after completing basic training and supervision before seeking EMDR accreditation as a practitioner. This process enables the practitioner to incorporate the theoretical basis of EMDR and use EMDR as a part of comprehensive therapy intervention (Farrell & Keenan 2013). In reality, we see that a variety of internal and external circumstances in the life of practitioners influence the training process which is reflected in shorter or longer pauses during the training. It might be more precise to talk about many individual factors of practitioners that do have significant influence in a formal qualification. In this article, we will present the experiences of practitioners from basic and supervision EMDR at the humanitarian non-governmental organization Trauma Aid UK in Bosnia and Herzegovina (BH) (Hasanovi et al. 2018, 2021).

Shape analysis is an important and powerful tool in a wide variety of medical applications. Many shape analysis techniques require shape representations which are in correspondence. Unfortunately, popular techniques for generating shape representations do not handle objects with complex geometry or topology well, and those that do are not typically readily available for non-expert users. We describe a method for generating correspondences across a population of objects using a given template. We also describe its implementation and distribution via SlicerSALT, an open-source platform for making powerful shape analysis techniques more widely available and usable. Finally, we show results of this implementation on mouse femur data.