Dimenhydrinate (DMH) is used for the prevention and treatment of nausea, vomiting, dizziness and vertigo associated with motion sickness in a dose of 50 mg 1. It’s made of two drugs in a form of salt, diphenhydramine and 8-chlorotheophylline which synergically decrease motion caused neural excitation 2. DMH is classified as a slightly soluble drug and it belongs to class II of BCS classification as a drug with low solubility and high permeability 3. Cyclodextrins (CDs) are cyclic oligosaccharides formed by α-1,4-linked glucose units with a hydrophilic outer surface and a lipophilic central cavity. Formation of inclusion complex by incorporating a drug in the central CD cavity provides improvement of physicochemical properties without molecular modifications. Solubility and dissolution rate of poorly water-soluble drugs can be increased 4. Aqueous solubility of natural CDs is limited due to their tendency to form H-bonded associations. However, due to multiple reactive hydroxyl groups, their functionality can be greatly increased by chemical modification 5. CDs’ substituted derivates can overcome poor solubility issues and enhance bioavailability. Hydroxypropylβ-CD (HP-β-CD) has good inclusion ability, high water solubility and it’s safe for intravenous and oral administration 6. Stability constant (Ks) and complexation efficacy (CE) are important for assessing the binding characteristics of the drug and CD. They can be determined by the phase solubility studies where the change of the drug solubility is corresponding to the concentration of CD 7. Linear (AL) type of the curve implies that one molecule of the drug forms inclusion complex with one molecule of the CD. Apparent stability constant K1:1 can be calculated from the following equation:

The development process of the knowledge-based engineering (KBE) system for the structural size optimization of external fixation device is presented in this paper. The system is based on algorithms for generative modeling, finite element model (FEM) analysis, and size optimization. All these algorithms are integrated into the CAD/CAM/CAE system CATIA. The initial CAD/FEM model of external fixation device is verified using experimental verification on the real design. Experimental testing is done for axial pressure. Axial stress and displacements are measured using tensometric analysis equipment. The proximal bone segment displacements were monitored by a displacement transducer, while the loading was controlled by a force transducer. Iterative hybrid optimization algorithm is developed by integration of global algorithm, based on the simulated annealing (SA) method and a local algorithm based on the conjugate gradient (CG) method. The cost function of size optimization is the minimization of the design volume. Constrains are given in a form of clinical interfragmentary displacement constrains, at the point of fracture and maximum allowed stresses for the material of the external fixation device. Optimization variables are chosen as design parameters of the external fixation device. The optimized model of external fixation device has smaller mass, better stress distribution, and smaller interfragmentary displacement, in correlation with the initial model.

The primary goal of the reformed enforcement law in Bosnia and Herzegovina (B&H) is efficient compensation. However, many impediments exist. In this paper, the authors present some of the problems and potential abuses of procedural rights in the enforcement law of B&H. Two instances of abuse of rights regarding real estate are presented, which can open the doorway to other abuses, as well. Also, the abuse of procedural rights in the enforcement procedure is seen as underexplored in legislation, doctrine and case law. The paper addresses similarities and differences between the entities’ and the Brcko District legal systems regarding the presented abuses, as well as comparative law. It is focused on the analysis of legislation and the interpretation thereof in light of recent case law in B&H and problems arising from it. The identified problems often prevent the goal of the enforcement procedure from being fulfilled. The paper has two parts, each dealing with one instance of abuse. The first part concerns the engineering of the most favourable offer in the bidding. The second part concerns the problem of a fictional offer to purchase real estate in the bidding and the character of the deposit. The paper provides suggestions for amending legislation based on some good legal solutions in the region.

Intent-based networking (IBN) solutions to managing complex ICT systems have become one of the key enablers of intelligent and autonomous network management. As the number of machine learning (ML) techniques deployed in IBN increases, it becomes increasingly important to understand their expected performance. Whereas IBN concepts are generally specific to the use case envisioned, the underlying platforms are generally heterogenous, comprised of complex processing units, including CPU/GPU, CPU/FPGA and CPU/TPU combinations, which needs to be considered when running the ML techniques chosen. We focus on a case study of IBNs in the so-called ICT supply chain systems, where multiple ICT artifacts are integrated in one system based on heterogeneous hardware platforms. Here, we are interested in the problem of benchmarking the computational performance of ML technique defined by the intents. Our benchmarking method is based on collaborative filtering techniques, relying on ML-based methods like Singular Value Decomposition and Stochastic Gradient Descent, assuming initial lack of explicit knowledge about the expected number of operations, framework, or the device processing characteristics. We show that it is possible to engineer a practical IBN system with various ML techniques with an accurate estimated performance based on data from a few benchmarks only.

The paper investigates the impact of fiscal policy on economic growth, foreign direct investment and employment in Bosnia and Herzegovina. The focus of research is fiscal policy, which as a lever of economic policy that affects economic growth and development. The aim of the research is to determine the impact of fiscal policy on the economy of Bosnia and Herzegovina and propose solutions for higher growth and development, a higher degree of foreign direct investment and reducing the unemployment rate. The results of the research show that the fiscal policy for the years that are the subject of the research, has affected the public debt of the state. High taxes and contributions have contributed to the spread of the gray economy, fiscal discipline is at a low level due to the management in this way of this lever of economic policy. Public financial management should be one of the key macroeconomic goals, with special emphasis on fiscal policy. The research went in the direction of analyzing current trends and proposals for improving the situation. The research aims to show the current statistical impact of variables on gross domestic product, on growth and development and the impact after the application of expansionary fiscal policy on the same variables. It is recommended that economic policy be conducted in the direction of releasing additional funds through the redistribution of taxes in favor of workers, in the direction of capital investments that will repay themselves, to reduce the rate of taxes and contributions on wages and with incentives for investors, to go towards stimulating production and tax reliefs for export-oriented activities with an effort to try to produce products whose production is possible in our conditions, and all this is mostly possible with the implementation of an expansive fiscal policy.

So far, recent literary criticism has paid attention exclusively to the poetry of Amir Brka. This work deals with prose creation, with constant emphasis on the compatibility of poetry and prose, and then prose and opinion journalism, for which the city of Tesanj is the motif backbone. The methodology of the work is based on mnemonics, under the hypothesis that Amir Brka, through a polyvalent opus, deconstructing the “dejected” space of the Bosnian town, reconstructed the timeless and all-spatial mnemotope of the city. In this way, Brka symbolically made a spatial turn in Bosnian literature, especially through the works Monograph of the City, Black Notebook and the book Jerej, which are, each in its own way, a fight against wrong ideologies and inputs that the text and book based on truth are the only credible mnemotopes.

Recent Bosnian criticism, directly or indirectly, deals with the issue of classification and systematization of Tvrtko Kulenović's literary work, which due to its specificity can hardly be reduced to usual conventions. This paper gives an overview of the very specificity of that, above all, polyvalent literary work, which encompasses travelogues, plays (dramas), essays and novels – genres that sometimes act separately, and sometimes represent a habitus, i.e. a unique textual universe of Tvrtko Kulenović.

The paper is the analysis of Ćopić’s novel Delije na Bihaću, i. e. of its marked lexis, which is divided into emotionally-expressive lexis and stylistically marked lexis. There are different typologies of lexis in our language (see e. g. Halilović/Tanović/Šehović 2009). This study, however, employs the classification offered by Katnić-Bakaršić (2007). The analysis includes idioms, loanwords and diminutives extracted from Ćopić’s final novel. Seeking the best way to describe experiences and impressions, Ćopić opted for emotive, inherently expressive language. The analysis of native idiomatic and lexical specifics of the novel reveals the extent to which the use of authentic lexis contributes to a more convincing and credible characterization of characters and gives a clearer picture of the social and linguistic aspects in Krajina during that particular period.

Recent technological advances in the field of genomics offer conservation managers and practitioners new tools to explore for conservation applications. Many of these tools are well developed and used by other life science fields, while others are still in development. Considering these technological possibilities, choosing the right tool(s) from the toolbox is crucial and can pose a challenging task. With this in mind, we strive to inspire, inform and illuminate managers and practitioners on how conservation efforts can benefit from the current genomic and biotechnological revolution. With inspirational case studies we show how new technologies can help resolve some of the main conservation challenges, while also informing how implementable the different technologies are. We here focus specifically on small population management, highlight the potential for genetic rescue, and discuss the opportunities in the field of gene editing to help with adaptation to changing environments. In addition, we delineate potential applications of gene drives for controlling invasive species. We illuminate that the genomic toolbox offers added benefit to conservation efforts, but also comes with limitations for the use of these novel emerging techniques.

Background: Left atrial dilatation, according to recent studies is important in the onset of atrial fibrillation, stroke and death. The most reliable echocardiographic parameter of left atrial dilatation is the left atrial volume index (LAVi). Aim: The objective of this study is to evaluate the impact of LAVi on the occurrence of atrial fibrillation after surgical myocardial revascularization (CABG). Methods: A prospective study included 116 patients undergoing surgical myocardial revascularization followed from admission to discharge. The examination was conducted at the Special Hospital “BH Centre for Heart” Tuzla. Preoperative ultrasound examination determined the parameters of left ventricular diastolic function and LAVi in all patients and postoperatively determined the onset of AF, the day of onset, duration in hours, number of episodes. Logistic regression was used to evaluate whether an event occurred or not, and the effect of time on the event of interest was analysed by Cox's parallel hazard regression. Results: 75.9% of patients had diastolic left ventricular dysfunction (LVDD). Preoperative values of LAVi are significantly higher when the LVDD grade is higher. In patients with LVDD and higher LAVi values, the risk of AF occurrence is greater, the longer the duration of AF, and the significantly greater number of AF episodes. As a result of the analysis, the most significant predictors of AF are: LVDD and LAVi. Conclusion: LAVi has the best hazard function in explaining the occurrence of atrial fibrillation after surgical myocardial revascularization.

Background: Empathy is an indispensable part of health care. The outcome of empathic response is satisfaction on sides, patient and health professionals. But it also requires a great deal of healthcare staff’s engagement what is exhausting and burdening. Many variables in increasing or decreasing way affect empathy.Aim: Combining facial emotion recognition and personal affective traits, the focus was to determine which one is a better predictor of health professional’s empathy.Methods: Therefore, a total of 150 health professionals was assessed in the level of empathy, position on extraversion-introversion dimension and ability to accurately recognize facial expressions of emotion. Gender and working experience were controlling variables in predicting the health professional’s empathy.Results: Generally, results show that extraverted health professionals with high accuracy of facial expression recognition have also higher empathy scores. Both studied variables were good predictors of health professional’s empathy whit a stronger unique contribution of personality traits.Conclusion: Managing health professionals human resources based on their empathy could serve, in long term, to prevent individual level occurrences such as burnout syndrome and extended work absenteeism, and on an organizational level many legal issues and to enhance better treatment outcomes, trust in health professionals with mutual satisfaction. Further studies are required for application in clinical settings. Keywords: empathy, facial expression, affective personality traits

Accurate information on the cause of death is obtained from expert teams based on pathological or forensic expertise. Reliable information can be obtained from physicians in hospital settings if the deceased person has been treated in such an institution and has previously been diagnosed with an illness (intrahospital mortality). Intrahospital mortality analysis provides reliable data that can be used in the planning of a bed fund, the amount of medication purchased, the purchase of equipment, the organization and creation of highly specialized medical teams (resuscitation team), the number of resuscitation procedures, the number of pathologists required for autopsy procedures, etc. The aim of the study was to determine the total number of deaths, to identify the most common causes of death and 10 leading diagnoses of deceased patients at the Internal Medicine Clinic, University Clinical Center Tuzla (UKC) during one calendar year (2011). Material and methodes: Archive material (case histories and reports of deceased patients of the Internal Medicine Clinic) were used. Results: During this period, 6 488 patients were treated at the Internal Medicine Clinic and 451 patients died. According to the analyzed data, the most common diagnoses and causes of death at the Internal Medicine Clinic were: cerebrovascular incidents 104 (20.84%), cardiogenic shock in 24 (5.31%), heart failure 59 (10.86%), hepatic coma with cirrhosis of the liver 25 (5.33%), sudden cardiac death 30 (6.53%), respiratory failure 15 (3.32%), myocardial infarction 41 (9.99%), multiorgan failure 18 (4.00%) , pulmonary edema 14 (3.10%), sepsis 6 (1.38%), pulmonary emboli 17 (3.82%), valvular heart disease 9 (1.92%), cardiorespiratory arrest 9 (1.92%) , malignant abdominal neoplasms in 23 (5.28%), pancreatitis 2 (0.44%), hematemesis 8 (1.76%), diabetes mellitus 4 (0.88%), lung tumor 1 (0.22%), chronic renal insufficiency 12(2.54%), suicidal intoxication 4 (0.88%), ileus 4 (0.88%), cachexia 3 (0.66%), restrictive cardiomyopathy 2 (0.44%), mesenteric thrombosis arteries 2 (0.44%), disseminated lupus erythematosus 2 (0.44%), coffee vein thrombosis inferior 2 (0.44%), and 1 (0.22%) died of an aneurysm aortic abdominalis, ventricular septal defect, amyloidosis, disseminated intravascular coagulation, systemic sclerosis, rheumatoid arthritis and breast tumors. Conclusion: During the analyzed period, 6488 patients were treated at the Internal Medicine Clinic and a total of 451 patients died. The most common cause of death in hospitalized patients is cardiovascular disease (n = 208; 41.68% of deaths), with cerebrovascular disease (n = 104; 20.84% of deaths) totaling 312 (62.25%) of deaths from cardio and cerebrovascular disease.