PAPA syndrome (Pyogenic Arthritis, Pyoderma gangrenosum and Acne) is an autosomal dominant, hereditary autoinflammatory disease resulting from mutations in the PstPiP1/Cd2BP1 gene on chromosome 15q. The disease begins in childhood, most often from the age of 2 to 11, and it is characterised by a triad of symptoms: pyogenic (sterile) arthritis, pyoderma gangrenosum and acne. The disease usually begins with arthritis and is rarely recognised in the initial stage. The appearance of skin symptoms of the disease, either acne or pyoderma gangrenosum, along with the previously existing arthritis, should arouse suspicion of the existence of PAPA syndrome and direct doctors to perform further genetic testing. The triad of symptoms does not always have to be present, but the presence of two of the three symptoms with a confirmed gene mutation is a sufficient criterion for the diagnosis of the disease. Biological drugs have shown the greatest effectiveness in treatment, and il1 inhibitors or tnF alpha inhibitors are most often used medications. in later life, the joint manifestations gradually calm down, but the skin manifestations can last for many years with frequent relapses and remissions even with applied therapy, which makes this syndrome a great challenge for the treatment of this disease. Considering the small number of cases with PAPA syndrome described in the literature, we present to you an interesting case of a twenty-five-year-old patient with this disease and his challenging diagnostic and therapeutic path from childhood to adulthood.

Robots do not need clothes to keep them warm or for other purely functional reasons; nevertheless, certain people choose to clothe their home robots. This paper contributes to an emerging interest in understanding the practice of clothing robots by analyzing how people dress up the pet-type companion robot aibo. We study a collection of 2320 Twitter posts with photos containing aibo robots in clothes provided for them by their owners. The collection of tweets spans four years (2018-2021). We report our findings regarding aibo clothing types, fashion trends, clothing choices in different use scenarios, and clothing sources. Our study provides insights into the benefits of clothing robots for users, different modes of robot fashion, and how users’ current practices of robot clothing design and use can inform the future design of companion robots.

In the last years, Deep learning (DL) has become an active research topic in the field of medical image analysis, in particular for the automatic segmentation of pathological volumes. In order to develop a robust and generalizable system, it is of crucial importance to define the most suitable training set, according to both the model and the aim. Nevertheless, there are still no common guidelines specifying the most appropriate sampling and dimensionality of the set. The aim of the study is to assess how different sampling methods, e.g., stratified and random, and different sizes of the training set affect the performances of DL models for automatic segmentation. All DL algorithms were based on a U-Net structure and were trained using a real-world multi-center and multi-scanner pelvic MRI database. The performances were evaluated and compared using the Dice Similarity Coefficient between manual and automatic masks and the number of false negatives obtained by the different algorithms. Our results suggest that if the size of the training set is sufficiently large, using a stratified approach based on dendrograms does not strongly affect the performances of the nets, otherwise leads to higher results. Further analysis is needed using different stratification methods and sample sizes.

ABSTRACT Introduction Refractory status epilepticus (RSE) is a diagnosis that can be made when tonic-clonic status epilepticus (SE) and focal SE cannot be stopped by at least two anti-seizure medications after 30 and 60 minutes, respectively, from the time of commencement. It could result in mortality, loss of functionality, neurological deficiency, and other serious short- and long-term effects. Areas covered This narrative review covers original clinical studies of any design and case series investigating long-term outcomes of RSE recorded after at least a year from the SE onset. Expert opinion The future of a patient with RSE rests mostly on the long-term effects of this severe pathological condition, which may be accompanied with systemic complications like hyperthermia, hyperkalemia, acidosis, and/or stress cardiomyopathy. Younger patients with less severe RSE of shorter duration, particularly of the convulsive kind, are reported to have better long-term outcomes. Previous studies on the factors influencing the long-term outcomes of RSE, however, did not link the outcomes to treatment options for the condition. Such circumstances currently prevent making any definitive recommendations on the treatment of RSE until future research with adequate statistical power is completed.

Abstract Adoption of eating habits starts early in life, through interaction with family members and alongside preschool settings that offer context for developing healthy lifestyles among children. The aim of this study was to explore the perceptions and practices of teachers and parents related to the development of healthy eating habits among preschool children. Focus groups were conducted with a total sample of 48 parents and teachers (three focus groups among parents and three among teachers) from 15 kindergartens in the Republic of Srpska, Bosnia, and Herzegovina. All of the mentioned kindergartens are part of the “Nutrition friendly preschool/school initiative”, a program aimed at creating and developing settings that support and improve children's health. Focus groups were audiotaped, transcribed verbatim, and analyzed according to the Framework Method. Teachers emphasized that good communication and support from parents are important factors for the development of healthy eating habits. During COVID‐19, direct communication with parents was restricted, and mutual activities among teachers, children, and parents were reduced. Lack of knowledge, finance, and time are perceived by parents as main obstacles to the improvement of children's healthy eating habits. All participants in the focus groups agreed that more education and informative material are needed so their skills related to good nutrition can be improved and adopted in a culture‐sensitive way. Mutual support, education, and dissemination of informative materials are imposed as particularly important needs by all actors involved in the upbringing of children in order to support the development of children's healthy eating habits.

In the spacious inundation area on the left bank of the lower course of the Sava River in Serbia, there is an abandoned meander Special Nature Reserve, “Obedska bara”, which represents a very important floodplain in this part of Europe. This area is characterized by an exceptional wealth of biodiversity with a significant presence of rare and endangered species of national and international importance. Hydrological conditions in the mentioned area were analyzed from the aspect of surface water movement in nature and conditions altered by human factors (after the construction of the road network, canals, etc.). The movement of surface water, i.e., the filling and emptying of the investigated area, parallel to the water level of the Sava River, is shown using a digital terrain model. Our simulation of the change in surface water level within the studied area included the display of underwater areas, both with the formation of a flood wave (i.e., increasing water level of the Sava) and with the outflow of water from the pond when the water level in the Sava was reduced in both scenarios (natural and conditions altered by human factors). GIS and terrain digitalization were used for geospatial and hydrological analyses and, based on this, maps that display endangered areas could be made. The obtained results show that the largest human impact was recorded at the water level of the Sava River 74 m above sea level. The aforementioned water regime changes were shown to negatively affect dominant vegetation, such as pedunculate oak and ash.

Polymers and polymer composite materials, due to their properties, are becoming increasingly important materials in industry. They are used in a wide range of applications in space and aerospace, aviation, marine and automotive industry, as well as in production of sports equipment, household appliances, medical equipment, etc. They are expected to withstand loads during their lifetime, which requires predicting the reliability of structural elements, i.e. knowledge of material properties. To achieve better properties, polymer materials are reinforced with different percentages of fibre-reinforced materials, including glass fibres. The paper presents the results of experimental determination of the mechanical properties of injection moulded PA6 polymer reinforced with 30% glass fibres, determined by tensile and impact tests.

It is known that gloss has a significant impact on colour measurement. The UV varnish used for surface finishing, spot effects, as well as special effects, such as 3D effects and formation of Braille, has a pronounced gloss effect. In this work, a comparison of the spectrophotometer measurement geometry influence on the colour measurement of an unprinted PVC sample covered with UV varnish was done. UV varnish was applied successively in layers, and patches with different number of varnish layers, from 1 to 12, were formed. Two spectrophotometers with different measurement geometries were used for the measurement: Konica Minolta CM-2600d with d/8 measurement geometry, with spectral reflection included and excluded, and different measurement aperture 3 and 8 mm, and X-Rite eXact with 45/0 measurement geometry. By comparing the measurements, it was estab-lished that there is a significant difference in the measured values between different measuring device geometries on the given samples, and that the number of UV varnish layers has a significant influence on this differenc

This paper presents a new method that enables automatic channel change in case of intense interference on the active channel of a wireless communication point-to-point link. Channel change algorithms on the master and slave side of the communication link are presented, which enable the automatic selection of a new communication channel from a predefined set of available communication channels. By applying this method, it is possible to maintain a stable communication link in case of intense unpredictable interference on the transmitter or receiver side. The method applies to two-way master-slave communication links, regardless of the frequency spectrum and the number of used communication channels.

Abstract Within this paper, the possibility of using advanced LoRa technology in the field of long-range remote control was considered. For testing purposes, a one-way point-to-point LoRa remote control link was implemented based on the LoRa Ra-02 SX1278 transceiver and the corresponding 32-bit Cortex-M3 microcontroller. The remote control application software is developed in the Arduino development environment. The implemented link was tested experimentally to check the range, data transfer speed and link stability. Test results show that LoRa transceiver modules can be used in the field of long-range remote control.

We consider the machinability of the material as a technological feature that expresses the ability of the material to remove the maximum number of shavings from its machined surface in the minimum time with satisfactory processing quality, with as little cutting force as possible and as little tool wear as possible. The aim of the experimental research in this work is to examine the significance of the influential kinematic parameters of the roughness of the machined surface, i.e. of wood density (ρ), feeding speed (s’) and the number of spiral cutting knices (z) in the process of planning massive wood on the roughness of the newly created processing surface, which will vary in 14 trials, of which 6 are repetitions in the central point of the compositional plan, where the roughness parameter Ra is obtained as an output value, and the analysis of experimental data from the point of view of possible achievement of a better quality of the processed surface. The obtained mathematical model is essentially applicable and can be used to optimize the machinability parameters in the planning process of solid wood, and the experimental results can be used in further research into other parameters of the machinability of solid wood in the planning process.

Paper presents comparative analysis of experimental and analytical results of mechanical properties on truss members. Deformations are experimentally determined on the model of plexiglass truss, using six strain gauges. Strain gauges are measuring the deformation of truss members at the pre-defined measuring points. Knowing modulus of the elasticity and Hooke’s law, it is possible to calculate the stress values. The experimental stress values will be compared with the values obtained by the software and the results will be analyzed.

Uvod: Mišićno-koštani poremećaji uzrokovani radom (engl. Work-Related Musculoskeletal Disorders – WRMSDs) najčešća su oboljenja povezana s radom, a opisuju širok dijapazon degenerativnih i upalnih stanja. WRMSDs pogađaju milione radnika na području cijele Evrope i svijeta, a sami poslodavci zbog njihovih posljedica troše milijarde eura. Zdravstvo kao poseban sektor ima jednu od najvećih prevalenci radom uzrokovanih mišićno-koštanih poremećaja (MKP) u svijetu daleko ispred građevinarstva, rudarstva i proizvodnje. Ispitanici i metode: U istraživanje bilo je uključeno 177 zdravstvenih profesionalca oba spola koji su svojim radom aktivno uključeni u pružanje zdravstvenih usluga, kategorizirani prema životnoj dobi i vrsti radnih zadataka koje obavljaju u različitim položajima tijela u okviru svojih stručnih službi. Instrumenti koji su se koristili u istraživanju su standardizirani holandski upitnik za MKP (Dutch Musculoskeletal Discomfort Questionnaire – DMQ), standardizirani upitnik za procjenu indeksa radne sposobnosti (Work Ability Index – WAI) i ergonomski interventni program. Istraživanje je trajalo od januara 2021. do oktobra 2021. godine. Rezultati: Najveća učestalost MKP povezanih s radom kod zdravstvenih profesionalaca prije i poslije provođenja ergonomskog interventnog programa bila je u području vrata (83,1% prije, 64,9% poslije), u regiji gornjeg dijela leđa (71,8% prije, 56,5% poslije) te u regiji donjeg dijela leđa (68,4% prije, 55,9% poslije). Prosječna vrijednost indeksa radne sposobnosti prije uvođenja ergonomskog interventnog programa iznosila je 35,44±8,59, dok se poslije provedenog ergonomskog interventnog programa statistički signifikantno povećala i iznosila je 38,40±7,30. Zaključak: Ergonomski interventni program je utjecao na smanjenje učestalosti MKP uzrokovanih radom, i povećanje radne sposobnost zdravstvenih profesionalaca.

Increased number of children with autism spectrum disorder (ASD) has also heightened interest in finding and providing appropriate interventions. Early intervention is implemented at the moment when deviations are noticed, without waiting for an official diagnosis. Parents are crucial participants in interventions carried out with children; therefore, this research considers interventions focused on training parents to work with children with ASD up to the age of six. For the purposes of this paper, we searched the following journals: Autism, Focus on Autism and Other Developmental Disabilities, and Research in Autism. The search was limited to editions from 2012 to 2022, and the following keywords were considered: parent training, early intervention, autism. References were searched manually. The initial search yielded a total of 992 articles. Twenty-four studies related to children up to six years old and involving parent training in early intervention were included in the analysis. Using a tool for assessing quantitative studies, the selected studies were evaluated, with each component assessed based on the information contained in the study as good, moderate, or weak. The overall rating for the paper can be strong, moderate, or weak. This paper highlights the importance of support to enhance parental competencies.