BACKGROUND The purpose of this study was to evaluate the additional benefits provided by the incorporation of platelet-rich plasma (PRP) into a regenerative protocol consisting of bovine porous bone mineral (BPBM) and guided tissue regeneration (GTR) in the treatment of intrabony defects in humans. METHODS Twenty-three paired intrabony defects were surgically treated using a split-mouth design. Defects were treated with BPBM/GTR/PRP (experimental group) or with BPBM/GTR (control group). The clinical parameters evaluated included changes in probing depth, clinical attachment level, and defect fill as revealed by reentry surgeries at 6 months. RESULTS Preoperative probing depths, attachment levels, and transoperative bone measurements were similar for the two groups. Post-surgical measurements taken at 6 months revealed that both treatment modalities resulted in a significant decrease in probing depth, gain in clinical attachment, and bone fill of the defects compared to baseline. Postoperative differences observed between the two groups were 0.72 +/- 0.36 mm at buccal sites and 0.90 +/- 0.32 mm at lingual sites for probing depth, 0.82 +/- 0.41 mm at buccal sites and 0.78 +/- 0.38 at lingual sites for gain in clinical attachment, and 0.85 +/- 0.36 mm at buccal sites and 0.94 +/- 0.42 mm at lingual sites for defect fill, all favoring the experimental sites. However, none of the differences were statistically significant. CONCLUSION Within the limitations related to using a small sample size, PRP did not significantly augment the effects of BPBM and GTR in promoting the clinical resolution of intrabony defects.

CONFLICT OF INTEREST: NONE DECLARED SUMMARY The register of oncological diseases in Canton Sarajevo is important as it can be used to track and improve healthcare, especially in older age groups. The oncological registers are a way of recording data, suitable as a source of indicators. In the analyzed register, 1124 new cases of malignancy were recorded. There are slightly more malignant diseases in male (53%). The incidence of cancer varies depending of the age of patients. This analysis gives us important estimation in the relation of cancer morbidity, cancer types, age distribution, demographic factors, cancer stages and important cancer risks. The register and the analysis give us a chance for correlating and comparing the state of oncological diseases with other countries.