The article analyses and compares two main concepts in the field of civic education: education for democratic citizenship (EDC), prevailing in European discourse, and global citizenship education (GCE), dominant in international organisations like UNESCO. The concepts and their content are presented and analysed, and the need for the shift to the GCE is illustrated by some global tendencies and serious challenges of the global world. The responsibility to include GCE into the European concept of civic education is pointed out, as well as the challenges GCE is facing within the policy and implementation of the global agenda, SDG 4 and Education 2030.

Modern economy, in first order Retail sector, are introducing new and modern technologies which improve sales, communication with customers as well as marketing decision process. Retail sector is more and more oriented to technologies which improve not just communication with possible customers but also information gathering for better decision making process. Among those technologies special place is given to Indoor Positioning Systems (IPS) technologies, specialized technologies which are used for locating the people and objects but also their movement as well as for communication with clients in the store. These technologies follows customers in the store, follow their movement across, communicate with them about offers and promotions but also are base for predictive marketing of retail sector which has a goal to achieve „offer to customers what they look for and what they really need“. These technologies are in limited usage in Banja Luka area but potential for their use is present. There is no enough demand from retails industry but having in mind that these technologies are raising in modern economies as well as predictions and trends it is to be expected that those technologies will be implemented in retail sector in this region too.

Tamara Kovačević-Preradović1,2, Bojan Stanetić1,2, Ljiljana Kos1,2, Vlastimir Vlatković2,3 1Department of Cardiology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina, 2Medical School, University of Banja Luka, Banja Luka, Bosnia and Herzegovina, 3Department of Nephrology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina; Case presentation

This paper presents a new approach to exploring bauxite deposits from underground mining works in the bauxitebearing mines of Bešpelj near Jajce in Bosnia and Herzegovina. In the area under consideration, bauxite deposits have been investigated and exploited for over 60 years. Despite the high degree of exploration in the geologically complicated structures of Bešpelj, there are numerous unexplored reserves. Up to now, they have been mainly investigated by drilling from the surface into the borehole network as dictated by legal geological regulations. Due to the increase in depths on which deposits are located and complex structural relationships, such research has become more expensive and less effective. From a geological point of view, the bauxite deposits have developed in the horizontal position. However, longlasting geological evolution from the Upper Cretaceous to the present, has brought deposits in very di erent structural positions. That is why we nd them in an inclined position, in subvertical and vertical, and often in an overturned position. For further research to become rational and e cient, a new approach of study from underground mining works was developed that will serve for study and then for the exploitation of bauxite deposits.

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were Received May 3, 2017. Accepted February 3, 2018. The study was supported by the Ministry of Science and Technology of the Republic of Srpska. Corresponding author: Snezana Pejic, “Vinca” Institute of Nuclear Sciences, P.O. Box 522, 11001 Belgrade, Serbia. Phone: (+381) 11 3408 303; Fax: (+381) 11 64 555 61; e-mail: snezana@ vin.bg.ac.rs. Abbreviations: AAA – abdominal aortic aneurysms, AOD – aortoiliac occlusive disease, ECM – extracellular matrix, HE – haematoxylin-eosin, HP – histopathological, MMPs – matrix metalloproteinases, SMCs – smooth muscle cells, TIMPs – tissue inhibitors of metalloproteinases. predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.

Implementation of IMRT offers possibility to escalate radiation therapy dose without increased acute and late toxicity. The aim of this study is to compare acute and late genitourinary and gastrointestinal toxicity in patients treated with IMRT and 3DCRT technique. This study included 35 patients in study group a treated with IMRT technique, and 35 patients in study group B treated with 3DCRT technique. Patients were selected and referred to radical radiotherapy treatment prostate cancer. Acute genitourinary and gastrointestinal toxicity was evaluated during radiotherapy treatment according to recommendation of RTOG group. Late gastrointestinal and genitourinary toxicity was evaluated during regular control exams after radical radiotherapy treatment for six months. Based on the results χ2 test there was no statistical significant difference (p>0,05) between study group a i B in terms of acute gastrointestinal and genitourinary despite escalated radiotherapy dose in study group B treated with IMRT technique. Based on the results χ2 test there was no statistical significant difference (p>0, 05) between study group a i B in terms of late gastrointestinal and genitourinary toxicity. Intensity modulated radiation therapy is optimal technique in the radical treatment prostate cancer. This technique allows clinical benefit compared with 3D conformal radiotherapy-escalation of radiotherapy dose without increased toxicity in patients treated with IMRT technique.