Pulmonary artery intimal sarcoma (PAS) is a rare mesenchymal tumor mostly diagnosed in middle-aged women. In a 63-year-old female, the radiological findings showed cavitation in the left upper lobe of the lung and infiltrative tumor mass around the left pulmonary artery. PAS consisted of small, round tumor cells with about 80% of mitotic activity and with myxoid background and specific immunoprofile and diagnosed as undifferentiated sarcoma with round cell features type. The final diagnosis of PAS was established according to the pathohistological, chest computed tomography scan, and surgery finding.

Staunton, CA, Stanger, JJ, Wundersitz, DW, Gordon, BA, Custovic, E, and Kingsley, MI. Criterion validity of a MARG sensor to assess countermovement jump performance in elite basketballers. J Strength Cond Res XX(X): 000-000, 2018-This study assessed the criterion validity of a magnetic, angular rate, and gravity (MARG) sensor to measure countermovement jump (CMJ) performance metrics, including CMJ kinetics before take-off, in elite basketballers. Fifty-four basketballers performed 2 CMJs on a force platform with data simultaneously recorded by a MARG sensor located centrally on the player's back. Vertical accelerations recorded from the MARG sensor were expressed relative to the direction of gravity. Jumps were analyzed by a blinded assessor and the best jump according to the force platform was used for comparison. Pearson correlation coefficients (r) and mean bias with 95% ratio limits of agreement (95% RLOA) were calculated between the MARG sensor and the force platform for jumps performed with correct technique (n = 44). The mean bias for all CMJ metrics was less than 3%. Ninety-five percent RLOA between MARG- and force platform-derived flight time and jump height were 1 ± 7% and 1 ± 15%, respectively. For CMJ performance metrics before takeoff, impulse displayed less random error (95% RLOA: 1 ± 13%) when compared with mean concentric power and time to maximum force displayed (95% RLOA: 0 ± 29% and 1 ± 34%, respectively). Correlations between MARG and force platform were significant for all CMJ metrics and ranged from large for jump height (r = 0.65) to nearly perfect for mean concentric power (r = 0.95). Strong relationships, low mean bias, and low random error between MARG and force platform suggest that MARG sensors can provide a practical and inexpensive tool to measure impulse and flight time-derived CMJ performance metrics.

In this paper, we outline several recent insights for the priorities and challenges for future research for reducing phosphorus (P) based water eutrophication in the agricultural landscapes of Northwest Europe. We highlight that new research efforts best be focused on headwater catchments as they are a key influence on the initial chemistry of the larger river catchments, and here many management interventions are most effectively made. We emphasize the lack of understanding on how climate change will impact on P losses from agricultural landscapes. Particularly, the capability to disentangle current and future trends in P fluxes, due to climate change itself, from climate driven changes in agricultural management practices and P inputs. Knowing that, future climatic change trajectories for Western Europe will accelerate the release of the most bioavailable soil P. We stress the ambiguities created by the large varieties of sources and storage/transfer processes involved in P emissions in landscapes and the need to develop specific data treatment methods or tracers able to circumvent them, thereby helping catchment managers to identify the ultimate P sources that most contribute to diffuse P emissions. We point out that soil and aqueous P exist not only in various chemical forms, but also in range of less considered physical forms e. g., dissolved, nanoparticulate, colloidal and other particulates, all affected differently by climate as well as other environmental factors, and require bespoke mitigation measures. We support increased high resolution monitoring of headwater catchments, to not only help verify the effectiveness of catchments mitigation strategies, but also add data to further develop new water quality models (e.g., those include Fe-P interactions) which can deal with climate and land use change effects within an uncertainty framework. We finally conclude that there is a crucial need for more integrative research efforts to deal with our incomplete understanding of the mechanisms and processes associated with the identification of critical source areas, P mobilization, delivery and biogeochemical processing, as otherwise even highintensity and high-resolution research efforts will only reveal an incomplete picture of the full global impact of the terrestrial derived P on downstream aquatic and marine ecosystems.

Most practicing physicians will recall from their training that the average prognosis for patients with central nervous system (CNS) metastases from melanoma was death within a matter of weeks to m...

Soft‐mouth trout, Salmo obtusirostris has disappeared from most of its historical distribution range in the River Neretva catchment. Remnant groups are highly fragmented and distribution of the species is restricted to only 15% of it's historical area. The most abundant length range of remnant individuals is between 20 and 40 cm; with a significant decrease of the bigger individuals. Age population structure is dominated by younger fish aged 2, 3 and 4 years, however, age class 4⁺ and 6⁺ predominated in the lower river part. Specimens older than 8 years were not observed, and estimated fishing mortality (F) was high, particularly in the upper part of the river (0.786). The River Neretva soft‐mouth trout population is under heavy pressure including anthropogenic habitat changes and illegal fishery, leading to disappearance in number of formerly inhabited areas. The Upper and Lower Neretva are the only areas where the species is still abundant. However, the collapse of the number of old individuals increases the risk of extinction of the remaining wild subpopulations.

Essentials Mortality due to bleeding vs. arterial thrombosis in dialysis patients is unknown. We compared death causes of 201 918 dialysis patients with the general population. Dialysis was associated with increased mortality risks of bleeding and arterial thrombosis. Clinicians should be aware of the increased bleeding and thrombosis risks.

We study numerically the formation of Majorana bound states in a finite-size quasi-one-dimensional square-lattice strip with Rashba spin-orbit coupling, in the presence of a proximity-induced superconducting pairing and a magnetic field perpendicular to the strip. We take into account both the Zeeman and orbital effects of the field. First, using the Majorana polarization, we demonstrate that such a system can host more than one pair of Majorana quasiparticles. We construct the corresponding topological phase diagram and we conclude that the topological regions are extended in the presence of orbital effects, however the gap protecting the topological states is reduced.

We present the reservoir pH replica exchange (R-pH-REM) method for constant pH simulations. The R-pH-REM method consists of a two-step procedure; the first step involves generation of one or more reservoirs of conformations. Each reservoir is obtained from a standard or enhanced molecular dynamics simulation with a constrained (fixed) protonation state. In the second step, fixed charge constraints are relaxed, as the structures from one or more reservoirs are periodically injected into a constant pH or a pH-replica exchange (pH-REM) simulation. The benefit of this two-step process is that the computationally intensive part of conformational search can be decoupled from constant pH simulations, and various techniques for enhanced conformational sampling can be applied without the need to integrate such techniques into the pH-REM framework. Simulations on blocked Lys, KK, and KAAE peptides were used to demonstrate an agreement between pH-REM and R-pH-REM simulations. While the reservoir simulations are not needed for these small test systems, the real need arises in cases when ionizable molecules can sample two or more conformations separated by a large energy barrier, such that adequate sampling is not achieved on a time scale of standard constant pH simulations. Such problems might be encountered in protein systems that exploit conformational transitions for function. A hypothetical case is studied, a small molecule with a large torsional barrier; while results of pH-REM simulations depend on the starting structure, R-pH-REM calculations on this model system are in excellent agreement with a theoretical model.

The purpose of this paper is to provide an overview and summary of selected sustainability-related academic programs and certificates delivered by universities and colleges located in the same geographic area (Grand Rapids, Michigan, U.S.).   Holistic and practical dimensions of creating and sustaining educational programs are evaluated, and emerging outcomes from universities with a history of prosperous sustainability studies programs are provided as models of applicability.  The possible effects of the level of formalizing sustainability in higher education and different aspects of academic-level sustainability programming at universities and colleges in a single geographic region were studied in a comparative perspective.  The study focused on the role of internal and external leadership, political and appointed officials, networking factors of various stakeholders, demand for sustainability in education, and the resources commitment in staffing.  We evaluated each element in the context of sustainability in education and longevity and self-support.  These findings and the concept of successfully developing and sustaining sustainability‑related academic programs in Grand Rapids (MI) are examined within a broad and holistic context encompassing educational, programmatic, socioeconomic, organizational, and leadership dimensions.  While further research is warranted, predictably, all elements performed well and added value to the conceptual framework of developing and sustaining sustainability-related academic programming with potential lessons applicable to the programmatic approaches to education domestically and abroad.

Embedding sustainability in an organization is often linked to effective leadership. By design, changes in leadership within the organization may lead to changes in commitment or perceived importance of sustainability in organizations.  While some leaders in organizations are interested in embedding sustainability within an organizational structure, other leaders believe in putting their own stamp on sustainability efforts. Using a mixed methodology approach to interviews and literature review, to confirm or dispel the underscored notion of the importance of leadership play in embedding sustainability within city organization. The research inquiry includes in-person interviews with top city staff and elected officials in a large Midwestern city, and a review of the internal documents and reports from the past 5 years, to examine the role that elected and appointed officials have in embedding sustainability within cities, and whether a change in leadership may have an impact on continuity of sustainability implementation and long term viability of such policies. The paper focuses on the implementation of sustainable energy policies within a municipal organizational structure as a mean of constructing a better understanding of leadership on sustainability implementation and embedment.  While the further inquiry is needed, the research points out that an active partnership between city managers, administrators, and elected officials must be in place to support integrating sustainability from within and that sustainability thrives where exhaustive leadership support such initiatives and efforts.