The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations. Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

In this work, the possibilities and benefits of using an ionic liquid as a potential dietary supplement are presented and discussed for the first time. Ionic liquids prevent the development of microorganisms due to high ion concentration and thus, prevent perishability of the food products. Thermal stability, structure, as well as the experimental density and viscosity in the temperature range from 20 to 50?C and at the atmospheric pressure 1x105 Pa of newly synthesized cholinium taurate ionic liquid, [Chol][Tau], are determined. According to the performed physicochemical characterization, it can be concluded that the synthesized ionic liquid is suitable for application in the food industry. The temperature variation of viscosity and density is discussed in terms of processes, packaging, and storage of [Chol][Tau]. Also, the antiproliferative activity of [Chol][Tau] is determined and compared with those obtained for ascorbic acid and Aspirin? as the standards.

Conjoined twins are an exceptionally rare phenomenon caused by partial separation of an early embryo after the twelfth day of fertilization. In this article we are reporting a case of conjoined twins diagnosed in our department. During a examination in the XXI week of gestation, a 24 years old woman, with the presence of labial herpes simplex following an ultrasound examination was suspected of carrying conjoined twins. To confirm, we performed prenatal Magnetic Resonance Imaging (MRI), which proved the existence of cephalothoracoomphalopagus.

The mass hierarchy among the three generations of quarks and charged leptons is one of the greatest mysteries in particle physics. In various flavor models, the origin of this phenomenon is attributed to a series of hierarchical spontaneous symmetry breakings, most of which are beyond the reach of particle colliders. We point out that the observation of a multipeaked stochastic gravitational wave signal from a series of cosmological phase transitions could well be a unique probe of the mechanism behind flavor hierarchies. To illustrate this point, we show how near future ground- and space-based gravitational wave observatories could detect up to three peaks in the recently proposed PS^{3} model.

ABSTRACT Resilience of power systems is highly impacted by factors such as increasing severity and frequency of weather events, but also smart grid advances that introduce major operational changes in power systems. Rapidly adapting to these changing circumstances and harnessing the potential of technological advances is the key to ensuring that power systems stay operational during disturbances, thereby improving resilience. This paper addresses this challenge by presenting an approach for improving resilience through local energy resource sharing across multiple distribution systems. The approach brings together the physical and the ICT layer of power systems through a self-organization approach that automatically alters the physical grid topology and forms local energy groups in order to mitigate the effects of widespread outages. Thereby, supply and demand are locally matched, and demand met is maximized during an outage. The results demonstrate that using the proposed approach, operational resilience of impacted distribution systems is improved.

Abstract A novel creatine blend (creatine nitrate mixed with creatinine, CN‐CRN) has been anecdotally suggested to be superior to traditional creatine formulations for bioavailability and performance. However, does CN‐CRN supremely affects creatine levels in the blood and skeletal muscle of healthy humans remain currently unknown. This randomized, controlled, double‐blind, crossover trial evaluated the acute effects of single‐dose CN‐CRN on serum creatine levels, and 5‐days intervention with CN‐CRN on skeletal muscle creatine and safety biomarkers in healthy men. Ten healthy young men (23.6 ± 2.9 years) were allocated to receive either CN‐CRN (3 grams of creatine nitrate mixed with 3 grams of creatinine), pure creatine nitrate (3 grams, CN), or regular creatine monohydrate (3 grams, CRM) by oral administration. We found that CN‐CRN resulted in a more powerful rise in serum creatine levels comparing to either CN or CRM after a single‐dose intervention, as evaluated with the area under the concentration–time curve calculation (701.1 ± 62.1 (µmol/L) × min versus 622.7 ± 62.9 (µmol/L) × min versus 466.3 ± 47.9 (µmol/L) × min; p < .001). The peak serum creatine levels at 60‐min sampling interval were significantly higher in CN‐CRN group (183.7 ± 15.5 µmol/L), as compared to CN group (163.8 ± 12.9 µmol/L) and CRM group (118.6 ± 12.9 µmol/L) (p < .001). This was accompanied by a significantly superior increase in muscle creatine levels after CN‐CRN administration at 5‐days follow‐up, as compared to CN and CRM, respectively (9.6% versus 8.0% versus 2.1%; p = .01). While 2 out of 10 participants were found to be nonresponsive to CN intervention (20.0%) (e.g., no amplification in muscle creatine levels found at 5‐days follow‐up), and 3 participants out of 10 were nonresponsive in CRM trial (30%), no nonresponders were found after CN‐CRN administration, with individual upswing in total muscle creatine varied in this group from 2.0% (lowest increment) to 16.8% (highest increment). Supplemental CN‐CRN significantly decreased estimated glomerular filtration rate (eGFR) at 5‐days follow‐up, as compared to other interventions (p = .004), with the average reduction was 14.8 ± 7.7% (95% confidence interval; from 9.3 to 20.3). Nevertheless, no single participant experienced a clinically relevant reduction in eGFR (< 60 ml/min/1.73 m2) throughout the course of the trial. Liver enzymes remained in reference ranges throughout the study, with no participant experienced high liver blood tests (e.g., AST > 40 units per L or ALT >56 units per L). Besides, no participant reported any major side effects during the trial, while the odors of CN‐CRN and CN formulations were considered somewhat unpleasant in 8 out of 10 participants (80.0%). Our results suggest that CN‐CRN is a preferred and relatively safe alternative to traditional creatine formulations for improved creatine bioavailability in the blood and skeletal muscle after single‐dose and 5‐days interventions.

We will prove that when uniformly distributed random numbers are sorted by value, their successive differences are a exponentially distributed random variable Ex(λ). For a set of n random numbers, the parameters of mathematical expectation and standard deviation is λ =n−1. The theorem was verified on four series of 200 sets of 101 random numbers each. The first series was obtained on the basis of decimals of the constant e=2.718281…, the second on the decimals of the constant π =3.141592…, the third on a Pseudo Random Number generated from Excel function RAND, and the fourth series of True Random Number generated from atmospheric noise. The obtained results confirm the application of the derived theorem in practice.

A prominent vein of comparative cognition research asks which cognitive abilities may be ascribed to different species. Here, we argue that the current structure of comparative cognition makes it near impossible to evaluate the accuracy of many of the claims produced by the field’s empirical research. We base this argument on six observations: i) the field is biased towards confirming more exceptional abilities in animals, ii) a likely high rate of false positive discovery, iii) the persistence of the bias towards more exceptional abilities, even in the presence of strong methodological criticism, iv) the absence of a formal method to assess evidence of absence of a cognitive ability, v) the ambiguity in definitions used to make claims, and vi) the small size of the research field. We then highlight how the widespread methodological and conceptual criticism in the comparative cognition literature does not facilitate scientific progress, rather it can impede it by creating an illusion of scientific rigour. Finally, we call for a reform of our research field that draws on recent developments in related fields and the Open Science movement.