This year Academy of medical sciences of Bosnia and Herzegovina (AMNuBiH) celebrates Anniversary - ten years from founding in the year 2009. Goals of founding of AMNuBiH were: a) promotion of medical sciences, b) improvement of all biomedical disciplines, and c) affirmation of contribution of biomedical sciences in the development of sciences in Bosnia and Herzegovina generally and especially in medicine in the country and abroad. AMNuBiH activities are: organization of scientific and professional meetings and publishing their results of research and investigations which promote B&H medical sciences and improve the health care system of B&H. Also, publishing of AMNuBiH indexed journals: Medicinski arhiv (Medical Archives), Materia Socio-Medica and Acta Informatica Medica, and cooperation with institutions in the country and abroad which goals and activities are the same or similar as AMNuBiH activities. Currently. Academy has 33 members. Facts about AMNuBiH activities during past 10 years are described in the book “Ten years of Anniversary of AMNuBiH: 2009-2019) and deposited on official web site of Academy: www.amn.ba.

Abstract This paper presents the design and development of a distributed measurement system for measuring pressure in high voltage circuit breakers (HV CB) and other switching apparatuses, during no-load operations. Instead of using traditional pressure transducers which require significant installation space, additional data acquisition cards and often demand for complex wiring, an in-house solution of pressure measurement is proposed. The system consists of miniature sensors, accompanied with a suitable amplifier, microcontroller unit and communication module, which may be distributed inside the interrupter unit in convenient locations. Due to the fact that the measurement values are transmitted digitally, measurement noise is significantly reduced while the wiring of the system is additionally simplified. The proposed measurement system is tested using two different interrupters (HV CB and a load break switch). The experimental results have demonstrated that the developed system is applicable, accurate, cost-effective, flexible and simple to use.

Abstract The magnitude-based Fourier descriptors (FD) are frequently used in shape-based image retrieval, due to their efficiency and effectiveness. Unlike the phase-preserving Fourier descriptors, the magnitude-based Fourier descriptors are inherently invariant under rotation and starting point change, but they discard all valuable information contained in the phase of the Fourier coefficients (FCs). In order to preserve the coefficients’ phase, the orientation and starting point of the shape must be determined. In this paper, we conducted a comprehensive evaluation of different state-of-the-art methods for determining nominal shape orientation, which can be used to extract phase-preserving Fourier descriptors: the point of maximal radius, the axis of least inertia (moments), the phase of the first harmonic, the cross-correlation, the Procrustes distance and the pseudomirror points. The methods were compared in terms of sensitivity to non-rigid transformations, retrieval performance, computational complexity and computational time. The experimental results give insight into the pros and cons of all analyzed methods.

A biographical note on Teodora Krajewska (1854-1935) reveals the details of her life and professional activities as an Austro-Hungarian and Yugoslav health officer (Amtsärztin) in Tuzla (1893-1899) and in Sarajevo (1899-1923). Teodora Krajewska, née Kosmowska was the third of nine official female doctors employed by the Austro-Hungarian administration in occupied Bosnia and Herzegovina (BH: 1878-1918) and charged with the special task of popularising public health and hygiene, particularly among Muslim women. A Polish intellectual and fervent patriot from Warsaw, Krajewska had left Congress Poland as a young widow in 1883 to study medicine in Geneva, Switzerland. In 1890, she became the first woman in Europe to be employed as an assistant professor at the medical faculty of the University of Geneva but was forced to resign in 1892. In the same year, she was both awarded her doctorate and appointed to the position of an Austro-Hungarian female health officer in Tuzla. After being nationalised in Austria, she reported for duty in Tuzla in March 1893. In 1899, she accepted her transfer to a newly created position in Sarajevo where she was active as an official physician until 1922/23. She contributed to contemporary medical science through her research on leprosy and osteomalacia in Bosnia. She returned to Warsaw in 1928 and devoted herself to the translation of Serbo-Croatian literature and writing her memoirs on her life and activities in BH.

Connected devices in IoT as well as the smartwatch market are getting more and more popular every year. The main mode of communication in IoT is an easy-to-use MQTT protocol suitable for devices with limited resources and battery power. Tizen is used for platforms such as mobile devices, smartwatches, TVs and even Linux kernel-based IoT devices. In this paper, we explain how MQTT protocol, Tizen operating systems and their architecture work, and suggest one possible implementation of a MQTT protocol for Smartwatches based on the Tizen operating system. We list the types of Tizen applications, develop a native application, and suggest possible future upgrades and appliances in IoT.

Introduction: Injuries to the radial nerve can occur at any point along its anatomical route, and the etiology quite varies. A particular entity are war injuries of the extremities, which have high morbidity but low mortality. After irreparable radial nerve injury, the only treatment is tendon transfer (if we neglect arthrodesis) with over then 40 methods. Four tendon transfers are considered as better than the other and two of them are the subject of our article flexor carpi radialis (FCR) and flexor carpi ulnaris (FCU). Aim: To evaluate the ultimate functional results of forearm tendon transfers for irreparable radial nerve damage caused by war injuries and indicate the better operative treatment choice in accordance with the evaluation schemes. Methods: This retrospective research included 40 patients with isolated irreparable radial nerve damage. Patients were operated from 1993 to 1996. The follow-up period is from 3.5 to 11.5 years (until 2007). Twenty patients were operated using FCR tendon transfer method and twenty patients were operated using FCU tendon transfer method. The surgery was performed at the Clinic for Reconstructive and Plastic Surgery, Clinical Center University of Sarajevo. Three score evaluation schemes were used: Zachary, Neumann Pertecke and Tajima scheme, along with subjective evaluation of treatment. Results: Measured by the Zachary Evaluation Scheme, the overall score in patients undergoing FCR tendon transfer is 92.25%. In patients undergoing FCU tendon transfer, the total score was 82.20%. The total result of all 40 operated patients was 87.25%. The Zachary evaluation scheme showed a significant difference between FCR and FCU results by tendon transfer (p <0.05) in favor of the FCR tendon transfer. Tajima scheme proved a statistically significant difference between the two tendon transfers (p = 0.024), also in favor of FCR tendon transfers. Conclusion: Forearm tendon transfer is a relevant method to compensate for the loss of function of the wrist, fingers and thumb extensions as a result of irreparable damage to the radial nerve. FCR tendon transfer provides better functional results than FCU tendon transfer in irreparable radial nerve damage. The time elapsed from the injury to the performed surgery of the tendon transfer has no effect on the final functional result. There is no surgical tendon transfer procedure that can be recommended as a standard for any patient. Practically, the surgeon must tailor the surgery to the patient’s needs. It is necessary to develop a unique and generally accepted evaluation scheme for the results of tendon transfers that will enable comparisons of results achieved. Both methods can be used for irreparable damage of radial nerve due to any etiology.

Background: The problem of heavy school bags is a global problem recognized in many countries in Europe and the world, including in Bosnia and Herzegovina. In addition to poor posture habits, "sedentary lifestyles" and insufficient physical activity, school bags is one of the main causes of low back pain and deformity in pupils. The recommendation of the World Health Organization (WHO) is that the weight of the school bag should not exceed 10% of the student's weight. However, in practice these limitations are far from reality with the obvious problems caused by too heavy bags. The aim of the paper is to identify and analyze the backbone load caused by the overweight school backpacks in real school work conditions and eliminate them by creating new solutions that are in line with ergonomic and biomechanical principles, as well as the recommendation given by WHO. Methods: The research included first grade primary school students at the age of seven, including their parents. The research began by interviewing parents with relevant questions, as well as measuring the students’ height and weight and the weight of their school backpacks. The analysis was performed in CATIA v5 software package (Dassault Systèmes, Vélizy-Villacoublay, France) using its advanced biomechanical modules. By knowing the anthropometric and work environment data with ergonomic design and analysis, the biomechanical analysis, rapid upper limb assessment (RULA) and carry analysis were performed. Results:  The conducted survey showed that 84% of students walk from home to school nineteen minutes on average and that 77% of them carry their school backpacks independently. Based on the measurements, it has been shown that, on average, the weight of the school backpacks is well above the WHO recommendation. A study conducted on a representative sample of students confirmed the relation between fatigue and spinal pain caused by carrying a heavy school bag. Computer analysis showed excessive loads on the spinal segment of L4/L5 that were outside the normal range of 3,400 N. Conclusions: A simulated computer analysis using RULA and biomechanical analysis with calculations of maximum loads in the lumbar segment of students found that school backpacks carried by students were too heavy for their age and well beyond the normal limits and WHO recommendations. The analysis showed that it is necessary to reduce the weight of the bag by about 30%.

Abstract The main aim of this paper is to investigate the productivity changes of microfinance institutions (MFIs) in Bosnia and Herzegovina (BiH) during and after the recent financial crisis. The study covers the period starting from 2008 until 2015. Using the Malmquist Productivity Index (MPI) over the sample of 10 MFIs and a balanced panel dataset of 80 observations, this study explores technical and technological change as well as total factor productivity (TFP) change. The empirical findings indicate a decline in TFP in most of the analyzed periods with an average decrease of 2.5%. The study reveals an average technological decline in the industry of 1.7%, while technical efficiency change is recorded at the level of -0.8%. Overall, crisis efficiency recovery occurred during the period between 2009 and 2013. However, due to technological inefficiencies, average total factor productivity change remains negative. Hence, policy makers need to enhance the technological progress in order to meet their strategic objectives in BiH MFIs.

Sexual functioning of war veterans is significantly under-explored. During devastating aggression on Bosnia-Herzegovina (BiH) around 400 thousand soldiers were included in combats. It is estimated that more than 100 000 persons were killed, and more than 60 000 them were soldiers. Vast majority of them were deployed since war is ended. We found high prevalence of sexual dysfunctions in war veterans. Also significant difference in several areas of sexual functioning between war veterans with and without symptoms of posttraumatic stress disorder was found.

Breast cancer consists of several intrinsic molecular subtypes, providing the basis for clinical treatment decisions. Lately, it is becoming increasingly recognized that factors other than the intrinsic cancer characteristics, such as immune components’ activity in the tumor microenvironment, have important effects on treatment choices and efficacy. bioSyntagma has developed a method, the Molecular Fingerprint (mPrint®), that enables multiplexed analysis of spatially defined regions in formalin-fixed, paraffin-embedded (FFPE) tumor samples allowing for analysis of the gene signatures unique to the tumor microenvironment. This method was applied to molecularly defined sets of breast cancers and used to evaluate four different tumor regions of interest (ROIs): 1) viable carcinoma proper (>90% cancer cells), 2) fibrotic tumor center (sparse cellularity), 3) interface between viable tumor and inflammatory component (tumor and inflammatory microenvironment) and 4) tissue away from the tumor (normal breast tissue). This was compared to the whole tissue scrapes from each patient block. Each ROI and tissue scrape was analyzed by high throughput qPCR for a panel of 248 genes using SmartChip technology (Takara Bio, USA). Sequential tissue slices from each patient were also analyzed using immunohistochemistry (IHC) for three targets and investigated for correlation with qPCR results for validation of the method. Overall, reasonable concordance was observed in general expression trends between selected IHC and RNA expression. qPCR data were further analyzed using hierarchical clustering analysis and showed that morphologically defined ROI’s cluster completely differently than traditional clustering of entire tissue scrapes. Notably, patient clustering based on morphological regions was independent of the intrinsic cancer subtype, as determined by molecular profiling of whole tissue scrapes, as well as independent of trends in Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI). These findings suggest that current methods of patient stratification based on whole tumor molecular subtyping may be inferior to stratification based on molecular characteristics of the tumor microenvironment. Citation Format: Colleen Ziegler, Isaiah Slemons, Chris DeSilva, Barbara Witkowski, Alain Mir, Sangeetha Anandakrishnan, Andrew Farmer, Elma Contreras, David Richardson, Semir Vranic, Zoran Gatalica, Dmitry N. Derkach. Novel method for patient stratification in breast carcinoma based upon spatial analysis of tumor microenvironment [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B094. doi:10.1158/1535-7163.TARG-19-B094

Introduction The workplace can be a source of stress. One of the most stressful professions is the profession of doctor of dental medicine (dentist). Multiple forms of stressors lead to such occupational stress. Objective The research objective was to examine stress levels among dentists in the 25 to 45 year age group. Materials and Methods This cross sectional study included 105 doctors of dental medicine throughout Bosnia and Herzegovina, aged between 25 and 45 years. The research was conducted by means of a confidential on-line survey. All participants signed the informed consent, and voluntarily filled out the survey form. The research used the PERCEIVED STRESS SCALE-PSS 10. The statistical analysis used the IBM Statistics SPSS v.21 statistics packages and Microsoft Excel 2010. Descriptive statistics, X2 test, and T-test were also used. Results Of the total number of respondents, n=105, 66 (63%) of them were female and 39 (37%) male respondents. The mean median value of the score was 23 (Mean = 23.080), as a result of which we can conclude that the respondents in the 25-45 year age population group that participated in this study showed a high level of stress based on the completed questionnaire and the answers received from the respondents. Conclusion The estimated level of stress has been shown to be high in both genders, with no statistically significant difference between genders.

Introduction: Basal cell carcinoma (BCC) is a non-melanocytic skin malignancy arising from basal cells of epidermis or follicular structures. Etiology of BCC is a multifactorial combination of genotype, phenotype, and environmental factors. There are several clinical variants of BCC including nodular, cystic, superficial, morphoeic, keratotic, pigmented and micronodular. Aim: The aim of our study was to analyze the recent clinical trends of basal cell carcinoma by reviewing a single institution’s experience. Methods: Total number of 422 patients clinically diagnosed with basal cell carcinoma were included in the study. Data on age, gender, skin type, personal and family history, duration of disease, localization of lesions, clinical type of lesions, and recurrence rate were collected and analyzed. The data were statistically evaluated. Results: More than 80% of all BCC’s were located on sun-exposed skin areas (p<0.05).The male /female ratio was 1:0.92. The nodular BCC was the most frequent type (59.2%), followed by the superficial (16.1%), pigmented (15.2%) and morphoeic (9.5%) types. The nodular and pigmented types were predominant located on the head and neck, whereas the trunk was the most common location for the superficial type (p<0.05). The tumor is commonly found in concomitance with skin lesion related to chronic sun exposure, such as actinic keratoses, solar lentigines and facial telangiectasia. During this study period, 41 cases showed recurrence of the cancer as the overall recurrence rate was 9.7%. There were no cases with metastasis or fatal outcome. Conclusions: The factors related to the development of BCC were older age and exposure to ultraviolet rays both in recreational and in occupational form. The prevention of BCC is based on the knowledge of risk factors, early diagnosis and treatment, particularly in susceptible populations.