Introduction: Genital warts are a frequent form of sexually transmitted disease. Cryotherapy represents the first line of therapy. Healing occurs in 94%, and recurrence in 10% . Side effects are common during the treatment. Aim: The aim of this study is to determine the successfulness of cryotherapy of genital warts, frequency of recurrence, and side effects. Patients and methods: In a retrospective study, data from 50 women with genital warts who were treated in the Gynecological Centre “Dr Mahira Jahić” in Tuzla in a period from 2012–2018 were analyzed. Every woman was treated with cryotherapy. Treatments were repeated every 7 days, maximal number of treatments being 7. In processing of data, X2statistical method was used. Results: 50% (N-25) of genital warts eliminated after 3 treatments with cryotherapy . Genital warts are eliminated in 78% (N-39) of women, while this treatment was unsuccessful in 18% (N-9). Recurrence after 3 months in 4% (N-2). Most common side effect was exudation in 78% (N-39), swelling in 72% (N-36) and pain in 66% (N-33). PAP smears in women with genital warts in 64% (N-34) of cases were inflammatory benign changes, while in 36% (N-18) mild abnormal changes in cells ASCUS and LSIL were found. LSIL lesions of cervix are more common (p<0,01) in women with genital warts of vulva. Conclusion: Cryotherapy is a method with a high success rate in healing of genital warts, and it decreases the concentration of HPV virus and removes the trigger that allows the development of cancer.

Abstract The economic authorities of each country seek to maintain the expansion phase through the implementation of various economic policy measures, namely, to prevent or mitigate the recessionary phase in economic development. In that context, it is of considerable importance to understand how monetary policy decisions affect the movement of macroeconomic variables. The paper aims to examine and evaluate the contribution of monetary policy to mitigating the effects of the global economic and financial crisis, using the Autoregressive Distributed Lag model, by analysing the impact of the real exchange rate, reference interest rate and money supply on the level of economic activity in Poland. Econometric analysis encompasses the period from 2006 to 2017. The research results suggest that there is a significant relationship between real economic activity and the real exchange rate both in the short and long term, but not between the reference interest rate and the money supply.

Research has shown technology fosters learning environments that stimulate improved academic performance, learners' satisfaction and completion rates. For this reason, an increasing number of researchers focus on the development of tools and applications that support the learning process of children. The tool presented here is a web application for educators, therapists, parents, and children with and without disabilities. The core concept of this tool is aiding professionals in creating relevant educational content and motivating children by presenting learning materials and tasks in a modern, relevant and motivating way. A pilot study was performed with five professionals, daily delivering instruction to children, mostly diagnosed with Autism Spectrum Disorder, at an NGO in Bosnia and Herzegovina. The study findings show a general positive attitude towards the use of the web tool in the classroom and its functionalities for creating teaching material.

Abstract The paper is aimed at identifying characteristics of trade relations of Bosnia and Herzegovina (BiH) with the Republic of Slovenia (Slovenia) in order to contribute to determining the position of BiH in its bilateral trade. The foreign trade analysis has been performed in the context of the changing trade regime between the two countries, thereby including both institutional and functional aspects of bilateral trade relations development. Different trade indicators have been calculated and interpreted for the period of 2003-2017 and/or for selected years which were identified by a change in the institutional regulations of mutual trade flows. The research results indicate increasing trade intensity between the two countries, with almost balanced export and import flows and with prevailing inter-industry trade. The trade performance of BiH has significantly improved, with increasing intra-industry specialization and trade. However, the export structure and comparative advantage pattern are not favourable toward BiH, which points to the need for improving the country’s position in its trade with Slovenia.

Virtual Reality (VR) storytelling enhances the immersion of users into virtual environments (VE). Its use in virtual cultural heritage presentations helps the revival of the genius loci (the spirit of the place) of cultural monuments. This paper aims to show that the use of actors in VR storytelling adds to the quality of user experience and improves the edutainment value of virtual cultural heritage applications. We will describe the Baiae dry visit application which takes us to a time travel in the city considered by the Roman elite as “Little Rome (Pusilla Roma)” and presently is only partially preserved under the sea.

Introduction: Neuralgic amyotrophy (NA) or Parsonage Turner syndrome is a clinical syndrome characterized by sudden attack of neuropathic pain, motor weakness and sensory loss that could be more or less clinically present. Different interpretations regarding the differential diagnosis, symptoms, cause and treatment were given till now. Aim: We report our experience with a 66-year-old male who had a sudden pain attack and palsy in shoulder region, without sensory loss, and associated calcific tendinitis of rotator cuff and degenerative changes in cervical spine. Case report: Patient came to our hospital with strong pain in shoulder area and signs of frozen shoulder. Active abduction and anteflexion was only to 30 degrees. He experienced the intense pain with visual analogue scale (VAS) 10/10 a night before, during his sleep. No trauma. Neurontin (gabapentin) was given to the patient. After 4 days, he felt better with abduction and anteflexion to 90 degrees. After 2 weeks VAS was 3/10, abduction and anteflection to 100 degrees. Conclusion: Neuralgic amyotrophy (NA) is a self-limiting inflammatory disorder usually with idiopathic etiology. The condition can be challenging to treat since many associated symptoms and diagnostic tests and procedures may mimic NA. In that case, accurate differential diagnosis is essential.

The main aim of the research was to determine the development of grammar and the use of grammatically complex sentences in stuttering and non-stuttering children, and to determine whether there are differences in the above abilities between these two groups of respondents. The sample of respondents consisted of a total of 64 children aged 56-83 months. Respondents are divided into two groups. The experimental group consisted of 32 stuttering children, of whom 19 were male and 13 female. The control group consisted of 32 children who did not stutter, and who compared with age and gender, were equal with the respondents of the experimental group. The research was conducted in preschools and elementary schools in the area of the Tuzla and Una-Sana Cantons in Bosnia and Herzegovina. The results of the study showed that stuttering children show statistically lower abilities during repetition of sentences, as well as recognition, understanding and use of common morphological forms. However, it is important to point out that children who stutter, regardless of significantly lower results than their fluent speaking peers, have shown above-average grammatical abilities. Also, the results showed that both children who stutter and children who do not stutter in their spontaneous speech use complex sentences.

Abstract Rationale: Appendiceal mucocele is a rare entity of mucinous cystic dilatation of the appendix. It has no typical clinical presentation and is considered a potentially premalignant condition. Patient concerns: We present a case of accidental intraoperative finding of an appendiceal mucocele in a 54-year old woman that clinically presented with an exacerbated chronic tubo-ovarian abscess. Diagnoses: Trans-vaginal ultrasonography showed an encapsulated, oval, unilocular mass above the uterus with a heteroechogenic structure, homogeneous fluid content, and smooth regular walls without inner proliferation. The histopathologic diagnosis was consistent with an appendiceal cystadenoma. Interventions: The patient underwent a simple appendectomy. Outcomes: There were no clinical, biochemical or imaging signs of the disease recurrence at 6 months follow up. Lessons: To our knowledge, this is the only well-documented case of appendiceal mucocele mimicking exacerbated chronic tubo-ovarian abscess reported in the literature. Awareness of a rare entity such as an appendiceal mucocele, which is frequently misdiagnosed as a potential cause of acute abdomen, is necessary for the appropriate management strategy in order to prevent complications.

Software-intensive systems in the automotive domain are often built in different variants, notably in order to support different market segments and legislation regions. Model-based concepts are frequently applied to manage complexity in such variable systems. However, the considered approaches are often focused on single-product development. In order to support variable products in a model-based systems engineering environment, we describe a tool-supported approach that allows us to annotate SysML models with variability data. Such variability information is exchanged between the system modeling tool and variability management tools through the Variability Exchange Language. The contribution of the paper includes the introduction of the model-based product line engineering tool chain and its application on a practical case study at Volvo Construction Equipment. Initial results suggest an improved efficiency in developing such a variable system.

Ear training is a vital element in music education, analogous to taking dictation in written language. It provides musicians with a crucial skill used to identify pitches, melodies, chords and rhythms. Traditionally, the training is conducted by a tutor using a musical instrument, typically a piano. However, with new technologies emerging, several computer applications to facilitate this aspect of music education have been developed. Nevertheless, none of them utilised the VR technology, that proved to be successful in various scenarios, including educational systems, simulations, etc. In this work, we designed and developed a virtual reality ear training system for interval recognition and investigated its usability and user experience and the effect of spatialised audio in a 3D virtual environment on user performance. The results showed that the system has been successfully designed and provides users with a great experience when using it.

Reduced physical activity and an increase in sedentary habits, as one of the factors in the development of cardiovascular diseases, hypertension, type 2 diabetes mellitus and other diseases, are also present in the youth population. The increasing of sedentary lifestyle and the reducing of physical activity can have negative consequences for the health of both genders, including increasing the risk of cardiovascular diseases (CVD). It is believed that almost 50% of young people do not practice regular physical activity. Regular physical activity reduces the risk in adults of early death caused by coronary heart disease, high blood pressure, type 2 diabetes mellitus, colon and breast cancer and depression. Studies investigating the sedentary lifestyle of young people in the United States show that the length of watching TV is directly proportional to the frequency of obesity. Daily moderate (medium-intensity) physical activity is beneficial for all people, regardless of age. The World Health Organization, within its "Health for All" strategy for the region of Europe, has set the goal for young people to be healthier and more capable to fulfill their roles in society in the year 2020 and that the psycho-social condition of people needs to be improved and help and service should be available to them, which will be better able to include and be more accessible to people with a mental health problem.

The school is an institution that represents an important link in the social care chain for children and young people, which also involves taking various measures to prevent the occurrence of undesirable behaviors. The aim of the study is to determine the prevalence of risk factors between adolescents with externalized and internalized problems and typically developing adolescents, and to determine in which segment, in the opinion of teachers, early social-pedagogical intervention is most needed. The research sample is made up of 450 students (233 male and 217 female) of the seventh and eighth grades of primary school. The results show that the highest risk factors are present in the group of students with externalized behavioral problems, slightly less in the group with internalized problems, and the least in students without behavioral and emotional problems. When it comes to early social-pedagogical interventions, in the opinion of teachers, they should be comprehensive and implemented by a competent expert.

Objectives According to the World Cancer Research Fund, over 380,000 new cases of endometrial cancer have been reported in 2018. After the identification of disease, histologic diagnosis is the main standard for managing further treatment approaches. The following analysis is aimed to examine cost-effectiveness of two preoperative endometrial sampling methods - hysteroscopy and curettage; comparing tumor localization, grading and staging in patients with endometrial cancer. Methods The differences in the specifications of 64 patients that underwent hysteroscopy or curettage in tertiary care center in Croatia were tested. According to five different guidelines, all cases of endometrial cancer were classified into groups of low risk, intermediate, high-intermediate or high risk. Statistical test used for analysis were Kolmogorov-Smirnov test, T-test ant the Z-test. Given data of 36 women who underwent hysteroscopy and 28 women who underwent curettage were analysed. Results Occurrence rates of Grade 1 and Grade 2 of endometrial cancer were higher in patients who underwent hysteroscopy (p=0.03572, p=0.03846) (picture 1). According to the classification of risk factors, no differences in incidence were found between two groups (picture 2). Conclusions In Croatia, the cervical dilation and curettage is a less-frequently used method despite being 62% more affordable than the hysteroscopy, while on the other hand, there is statistically significant difference in preferred choice of the two methods given the histologic grade of cancer and age at the time of diagnosis.

Objectives The aim of this paper is to present a case of an IVF pregnancy of a 43-year old women being treated for recurrent endometrial cancer stage IA, grade I. Methods Our patient was initially treated five years ago when hysteroscopic ablation of endometrial polyp was performed. Pathologic examination of biopsy specimen reported a diagnosis of atypical polypoid adenomyoma. Two years later, patient was evaluated for recurrent local disease. At that time, pathologic examination revealed typical polypoid adenomyoma with presence of few glands with characteristics of well differentiated endometrioid adenocarcinoma stage IA, grade I. Results After a complete evaluation of cancer staging and a detailed explanation, patient rejected conventional surgical treatment and fertility preserving treatment was started. Progestin therapy via an intrauterine device (IUD) was administered. One year later, IUD was removed and patient underwent IVF cycle with a transfer of 3 embryos without success. At the age of 43, pregnancy was achieved in IVF cycle with administration of hCG. Conclusions Although there are existing evidence of effectiveness for using IUD progestin therapy in endometrial hyperplasia, studies for its use in treatment of endometrial cancer are lacking. We report a case of successful use of leveonorgestrel - IUD alone in fertility preserving treatment followed by achieved pregnancy.