Since 1874, possibility of gastric mucosa infection was discussed as a cause of ulcer forming. In 1893 spirochette in gastric mucosa of animals were described. In 1940 bacteria in gastric mucosa of patients with ulcers and cancers were found. In 1983, a new era in gastroenterology begun with synchronic discoveries of bacterial etiology of chronic gastritis and ulcer disease. Australian scientists Barry Marshall and Robin Warren were the first who publisher results about relations between gastric mucosa spiral microorganisms and chronic gastritis. Previously named Campilobacter--like organisms evolved to Helicobacter pylori. In 1994, International Agency for Research on Cancer (IARC) sorted H. pylori in first class of carcinogenics for etiological role in B-cell lymphoma and gastric cancer.
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