The Dallas consensus was used to reveal active or borderline inflammatory loci by light microscopy (LM). When lymphocyte-cardiocyte interaction was observed by electron microscopy (EM), the deleterious or dormant pattern of inflammatory process was recognized. The first was determined by lymphocytes that adhered to cardiocytes, next to necrotic cardiocytes or admixed with debris. The second was marked by scattered lymphocytes between preserved cardiocytes and the absence of lymphocytes adhered to cardiocytes and necrotic cardiocytes. The deleterious pattern of the inflammatory process (EM) commonly supplemented the active appearance of inflammatory loci (LM). In contrast, the borderline outlook of the LM completed either the deleterious or dormant pattern of the EM. This discrepancy was related to the restricted resolution of LM, which might hide the actual stage of the disease. The diagnosis of myocarditis was founded on mutual LM and EM observations. The active or borderline appearance of LM of the deleterious pattern (EM) was considered indicative for the active stage of myocarditis. The borderline outlook of the LM of the dormant pattern of the EM was admitted to indicate either the healing phase of the disease with lymphocytes still lagging behind, or a latent phase of the ongoing myocarditis, according to the patient's hemodynamic status.

The increase of morbidity concerning diseases of heart, CNS, kidneys and of other organs is primarily connected with atherosclerotic changes of blood vessels. The population of cardiovascular patients includes a great number of diabetics and in that case manifestations of illness are directly conditioned and connected with changes of blood vessels.

Laboratory rats were exposed to the effect of intermittent hypoxia every other day over the 11-day period. Condition characteristics of 7000 m of height above see level were imitated. The indirect immunofluorescence staining was used in order to study morphodynamic turnover of adrenalin and noradrenalin cells. The results obtained have shown that the contents of adrenalin and noradrenalin cells in the medulla of the adrenal gland were mobilized. The discussion in the paper favours the probability that bioeffect of hypoxia may be expressed via the catecholamine system.

The objective of intraoperative histological diagnostics of thyroid gland diseases using the tissue freezing method is planning the appropriate surgical scope at the time of operation. This necessitates maximal diagnostic accuracy having in mind the fact that freezing changes the tissue structure resulting in numerous technical defects in the histological preparation. These defects can be eliminated by multiplying histomorphological criteria, accurate explanation of their significance and interdependency and by making a conclusion in the form of ex tempore diagnosis. We studied 88 cases of ex tempore diagnosed changes in the thyroid gland using 15 different morphological criteria. The adjustment of the metrics scale to arithmetic progression enabled us to use certain number of parametric tests. A universal approach along with non-parametric methods with highly significant results made it possible to evaluate histomorphological criteria which can be regularly used in intraoperative diagnostics of pathological changes in the thyroid gland.

The analysis comprised 240 uterine carcinomas: 145 carcinomas of the cervix and 95 carcinomas of the corpus uteri. Preoperatively 100 patients--57 with the carcinoma of the cervix and 43 with the carcinoma of the uterine body--were radiated with Co60 intracavitary. In the first stage of the carcinoma of the cervix a five-year survival in primarily operated patients amounted to 74.30% and in the group of preoperatively intracavitary radiated patients to 83%. In patients with the stage I carcinoma of the corpus uteri a five-year survival proved to be 69.57% if primarily operated and 93.75% if preoperatively radiated. Local relapses were recorded in 33 patients surgically treated for carcinoma of the uterine cervix and in 9 patients surgically treated for the carcinoma of the uterine body. In both these localizations the relapses were more frequent in the group primarily operated patients: in patients with the primarily operated carcinoma of the cervix the relapses occurred in 20.69% and in preoperatively radiated patients in 3.4% of cases. The same observations were recorded in the carcinoma of the corpus uteri (11.51% : 6.97%). This means that the relapses were six times as frequent in patients with the primarily operated carcinoma of the uterine cervix and about 1.65 times as frequent in those with the primarily operated carcinoma of the corpus uteri as in intracavitary radiated patients.

: Genotoxic and cytotoxic effects of curcumin and sunset yellow were tested by the chromosome aberration analysis and cytokinesis-block micronu - cleus cytome assay in human lymphocyte culture. Water solutions of food dyes, in concentrations of 1, 2, 4 and 8 mM, were added to the cultures at the beginning of the cultivation period. Concentrations of 4 and 8 mM of sunset yellow induced significant increase in frequencies of cells with chromosome aberrations. Tested concentrations of sunset yellow significantly associated with frequencies of structural aberrations, chromatid-type aberrations, total aberrant cells and micronuclei showing considerable dose dependent clastogenic activity. In higher analyzed concentrations, curcumin significantly increased only nuclear buds frequency, sug - gesting its potential genotoxicity, while sunset yellow showed dose-dependent genotoxic potential. Obtained results point toward favorization of natural coloring agents in food consumption and emphasize the need of controlled use of food colorants