Introduction: Healthcare organizations are faced with numerous problems, including a chronic lack of financial resources. Aim: To determine the difference in familiarity with the standards related to the quality management system between the primary, secondary and tertiary levels of health care, to determine the difference in the implementation of the quality system; determine the connection between the implementation of the quality system and the satisfaction of service users – patient. Materials and methods: Statistical processing of all data from the survey questionnaire was performed in the SPSS 17.0 package (SPSS Inc.). The level of statistical significance was set at 0.05, and all confidence intervals are given at the 95% level. The normality of the distributions was checked by Shapiro-Wilk tests when the samples were smaller than n=30, and by the Kolmogorov-Smirnov test for larger samples. Given that in most cases they indicated statistically significant deviations from normal distributions, the median and interquartile ranges were used as measures of central tendency and dispersion. Mutual comparisons of all three levels of health activity were analyzed with the Mann-Whitney U test, with Bonferroni’s correction of the level of statistical significance. The survey questionnaire was sent to the addresses of a total of 110 BiH health institutions at the primary, secondary and tertiary levels of health care. In the period June/July 2024, a total of 86 completed survey questionnaires were collected, which represents 76,18 % of all respondents. Conclusion: Research on a sample of primary, secondary and tertiary healthcare institutions in Bosnia and Herzegovina showed that the knowledge and application of the quality management system is still insufficient and points to the need to raise awareness of the importance of the application of the quality management system. Clinical hospital centers, as expected, given the application of the highest standard of medicine and the highest level of provision of health services, showed: greater knowledge of the importance of the quality management system and representation of quality assurance requirements of the ISO standard. The research also found that healthcare institutions that use international standards of quality management systems perform systematic monitoring of patient satisfaction with

stevens-Johnson syndrome (sJs) and toxic epidermal necrolysis (Ten) are severe, life-threatening mucocutaneous hypersensitivity reactions. The inflammatory response is mediated by cytotoxic T lymphocytes and nk (natural killer) cells with cytotoxic proteins and cytokines as mediators in the onset of cell apoptosis. drugs are responsible for about 95% of cases of toxic epidermal necrolysis. although non-steroidal anti-inflammatory drugs (nsaid) are classified as drugs that can potentially lead to this hypersensitivity reaction, a small number of cases have been described in the literature regarding the occurrence of this reaction to the use of ibuprofen. We present the case of a 58-year-old man who developed symptoms of Ten seven days after using ibuprofen. The treatment of toxic epidermal necrolysis is still a matter of debate. Given that there is no uniform protocol for treatment, and the lethal outcome in such conditions occurs in about 40% of cases, each presented case is significant in terms of considering the effectiveness and improvement of the therapeutic approach.