Ibuprofen – Induced toxIc epIdermal necrolysIs – a case report Toksična epidermalna nekroliza inducirana ibuprofenom – prikaz bolesnika
stevens-Johnson syndrome (sJs) and toxic epidermal necrolysis (Ten) are severe, life-threatening mucocutaneous hypersensitivity reactions. The inflammatory response is mediated by cytotoxic T lymphocytes and nk (natural killer) cells with cytotoxic proteins and cytokines as mediators in the onset of cell apoptosis. drugs are responsible for about 95% of cases of toxic epidermal necrolysis. although non-steroidal anti-inflammatory drugs (nsaid) are classified as drugs that can potentially lead to this hypersensitivity reaction, a small number of cases have been described in the literature regarding the occurrence of this reaction to the use of ibuprofen. We present the case of a 58-year-old man who developed symptoms of Ten seven days after using ibuprofen. The treatment of toxic epidermal necrolysis is still a matter of debate. Given that there is no uniform protocol for treatment, and the lethal outcome in such conditions occurs in about 40% of cases, each presented case is significant in terms of considering the effectiveness and improvement of the therapeutic approach.