Human Cytomegalovirus are a ubiquitous herpesvirus establishing virus-infections which are usually asymptomatic in immunocompetent individuals. In patients with Acquired Immunodeficiency Syndrome (AIDS) and immunocompromised hosts, the virus causes primary, latent or chronic persistent infection. Primary CMV infection is very severe in immunocompromised patients as well as among healthy population. Among patients with AIDS Cytomegalovirus (CMV) is usually isolated from patients specimen in association with other pathogens (Pneumocystis carinii, Candida albicans). The prevalence of serious CMV (chorioretinitis, gastrointestinal disease, interstitial pneumonia and central nervous system disease), in AIDS population are respectable.

Isolated organs: human ureter, and oesophagus, stomach, ileum, urinary bladder and vas deferns from the experimental animals were used in the investigations of the effect of five immunomodificators (Murabutid, Thymopenthin, MDP-401, MDP-409 and TGGA). The isolated organs were used as isolated innervated organs (IIO), i.e., they were contracting by stimulating extrinsic or intrinsic motor nerves. A number of animals were sensibilised by antigens, the antigen-antibody reaction (AAR) in vitro being induced. The substances investigated in micromolar concentrations modified contral contraction slightly. The modification of the AAR was also rather low and insignificant. There remains the problem of the visualization of AAR to be solved and the effect of immunomodificators in vitro on the IIO to be established.