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Amira Cipurković

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Copper (II) complexes with commercial antibiotics, amoxicillin (AMX), azithromycin (AZT) and ciprofloxacin (CFL) were synthesized and isolated as solids. Structures of the isolated products were determined by FTIR spectroscopy. Antibacterial activities were determined on reference bacterial strains from the ATCC collection by diffusion technique. The results show that AMX and CFL coordinate Cu (II) ion as bidentate O-donor ligand. AZT coordinates metal center as bidentate NO-donor ligand. A difference in the morphology of antibiotic crystals and the synthesized complexes was found. Complex of Cu (AMX)2 show complete absence of antibacterial activity, while the other com-plexes show the same or even lower activity than the parent ligands.  

In this paper, three complexes with 8-hydroxyquinoline (8-HQ) were synthesized, their spectral analysis was performed and the antimicrobial effect was examined in vitro. The stoichiometric ratio of the complex was determined conductometrically and spectrophotometrically. FTIR and UV/VIS spectroscopy were used for structural characterization. Antimicrobial activity was examined by diffusion technique on selected gram-positive and gram-negative bacteria, and C. albicans. Square planar and octahedral geometry complexes were synthesized by mixing in a molar ratio of 1:2 (M:L). Based on the spectral data, it is concluded that both oxygen and nitrogen atoms from 8-HQ are involved in the formation of the complex. The antimicrobial activity of the complexes is high, with zones of inhibition in the range of 15 - 28 mm. 8-HQ was shown to have a significantly higher ability to inhibit the growth of the tested microorganisms.

N. Hasić, E. Horozić, A. Cipurković, A. Antić, Z. Mujić, K. Pelemiš, K. Brkić, D. Bjelošević

: The chemistry of complex compounds containing imine ligands is attracting significant attention from research-ers today. In this work, complexes of selected transition metals (Cu, Co, Ni and Fe) with imines based on ninhydrin and amino acids methionine and cysteine were synthesized. FTIR and UV/VIS spectroscopy were used for structural characterization. Antioxidant activity of the complex was analyzed by the FRAP method. The synthesized compounds showed a significant reducing ability, ranging from 221.94 to 756.30 µmol/L. In vitro antimicrobial activity was tested on strains from the ATCC collection. Inhibitory activity against the tested microorganisms was recorded, and the zones of inhibition ranged from 10-24 mm. Preliminary research shows that these compounds have biological potency, but more detailed in vitro and in vivo studies are required for their use.

M. El-Ajaily, A. Sarangi, R. Mohapatra, Saffa S. Hassan, Rehab N. Eldaghare, P. Mohapatra, M. K. Raval, D. Das, A. Mahal et al.

The anticancer studies of a Schiff base; (E)-2((2-hydroxybenzylidene)amino-3-mercaptopropanoic acid (H2L) (obtained from 2hydroxybenzaldehyde and L-cysteine) and its transition metal complexes have been reported. The evaluation of the growth inhibitory action was studied for the compounds against human colon carcinoma (HCT-116), human hepatocellular liver carcinoma (HEPG-2), normal melanocytes (HFB-4) and human breast carcinoma (MCF-7) cell lines. The obtained results revealed that the Schiff base and its chelates are active against human hepatocellular liver carcinoma (HEPG-2) cell lines. The powder X-ray diffraction analysis for the compounds was carried out through Phillips X’Pert High score software. The density functional theory computation for ligand and Co(II), Ni (II) and Cu(II) metal complexes were made to understand the mode of bonding by GAUSSIAN 03 rev. A.01 programme. The quantitative structure-activity relationship investigation was performed by using HyperChem Professional 8.0.3 software to understand the biological potency of the ligands. Moreover, a docking analysis using iGEMDOCKv2.1 software was carried out against the kinase enzyme PDB ID:1fvv.

The aim of this work was to investigate the interaction of Imatinib mesylate with biological ions Cu(II), Co(II) and Ni(II) in ethanol/water solutions. Structures of synthesized complexes were characterized by spectroscopy methods. Stereo-microscopy was used for determination of morphological properties of obtained crystals. The results of IR spectroscopy showed that biogenic metal complexes with ImM were formed through the oxygen donors of mesylate ion. Changes of crystals colours and sizes of the parent ligand and complexes were clearly seen. Antimicrobial screening revealed a significant effect of Co(ImM)2 complex on the tested microorganisms. This complex also showed significant antioxidant activity compared to Ni(II) and Cu(II) complexes.

: pABA (p-aminobenzoic acid or 4-aminobenzoic acid) is a chemical component of the folate mole-cule produced by plants and bacteria, and found in many foods. It is best known as a UV-blocking sunscreen applied to the skin, and is sometimes taken orally for certain medical conditions. Today it is known that many organic molecules in the human body can react with biometals such as copper, cobalt, manganese, iron and others. This study was performed to investigate the interaction of Cu(II) ions with p-aminobenzoic acid. Spectroscopic methods (FTIR and UV/Vis spectroscopy) were used to characterize the product obtained. The antimicrobial activity of the synthesized complex was tested by diffusion techniques. The results of spectroscopic analysis indicate the interaction of Cu(II) ions with pABA. Interaction is realized through oxygen donor atom of ligand. It was found that the Cu(II) complex has significant antimicrobial activity compared to the pABA ligand.

Ciprofloxacin, CFL is a drug that belongs to the second generation of fluoroquinolone antibiotics with a wide range of effects on Gram-positive and Gram-negative bacteria. The aim of this work was to investigate the interaction of CFL as ligand with divalent biological cations (Mn2+, Ni2+ and Co2+) in approximate physiological conditions. Synthesized complexes were characterized using FTIR and stereo-microscopy. Antimicrobial screening was performed on bacterial strains of Escherichia coli, Salmonella Enteritidis, Enterococcus faecalis and Staphylococcus aureus. The results of FTIR spectroscopy showed that the M(II) complexes with CFL were formed through the oxygen donors of the carboxyl and carbonyl group of the ligand. Stereo-microscopic characterization revealed the difference in color and size of crystals of the ligand and metal complexes. Antimicrobial screening has shown that CFL and complexes have almost similar antimicrobial activity against investigated bacterial strains.

A. Cipurković, Ilvana Trumić, Zorica Hodžic, V. Selimbašić, Abdel Djozić

The potential negative impact of heavy metals on the ecosystem and human health in particular is evident. People are exposed to heavy metals through plant and animal food, water, soil and air. In industrial regions environment is usually contaminated with heavy metals. The theme of this research is to determine which metal elements are introduced into the production process of Portland cement in a cement factory in Lukavac (FCL) and to determine the metal input rate and their distribution at the entrance and exit of the process. In the process of production of cement clinker in FCL, metal elements are mostly entered by primary raw materials: limestone, marl lime, clay stone, sand; coal fly ash as secondary raw material and brown coal as regular fuel, generally come out with a finished solid products: clinker, cement and cement dust from the bag filter or gases. Coal fly ash and natural gypsum are used as additives for PC production. All refractory metals generally tend to be incorporated into the clinker, while the lower part, especially volatile and semi volatile metals (Cd, Hg), accumulates in the cement kiln dust. Most metals in cement are infused with clinker, except mercury and cobalt, which are entered from the ashes. Concentrations of metals at the entrance and exit of the kiln were determined using a Perkin - Elmer Inductively Coupled Plasma-Optical Emission Spectrometer.

A. Cipurković, Ilvana Trumić, V. Selimbašić, Abdel Djozić

The objective of this work was to determine the degree of mercury contamination in soils collected from the banks of Jala and Spreča Rivers and the extent to which the soils quality has deteriorated. As possible source of this hazardous heavy metal, it was also investigated the pollution of soils in the area of Ltd. Polihem plant, in which Hg was applied as cathode in process of chlorine-alkali electrolysis during a period of 1977-1992. Mercury content of 3,864 g/kg in soil near electrolysis plant was measured. The extent of soils quality deterioration was observed in all the sampling points from river banks below Ltd. Polihem, which demonstrates that the contamination may be attributed mainly to wastewater dispersion of mercury from factory. The levels of mercury decreased with an increase in distance of sampling points from Ltd Polihem. In this study, metal in the soil was determined using ICP-OES method. The study revealed that Hg levels were higher than the EU Directives proposed limit. The mercury contamination in the soils was also evaluated by applying enrichment factor (EF), contamination factor (CF), geo-accumulation factor (Igeo) and pollution-load index (PLI). Based on EF, the soils from river banks have moderate to extremely high enrichment factor. According to CF, mercury is responsible for significant contamination to very high. According to Igeo, soils are moderately to extremely poluted by Hg. Based on PLI, all sampling sites suggest overall pollution of site quality. Depending on Hg content, these soils cannot be recommended for agricultural activities because the accumulated metal in the soil may risk the agricultural plants. It is most likely that the foodstuff in this study environment might be at the highest risk of induced mercury contamination, which may have hazardous effect on human health.

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