Introduction Serological detection of SARS-CoV-2-specific immunoglobulins G (IgG) and M (IgM) antibodies is becoming increasingly important in the management of the COVID-19 pandemic. Methods We report the first results of COVID-19 serological testing in Bosnia and Herzegovina on 2841 samples collected and analysed in 2 medical institutions in Sarajevo. Antibody detection was performed using commercially available kits. Results In the first cohort, 43 IgM-positive/IgG-negative and 16 IgM-positive/IgG-positive individuals were detected, corresponding to 3.41% of participants having developed antibodies. In the second cohort, 4.28% participants were found to be IgM-negative/IgG-positive. Conclusions Our results suggest the need for population-wide serological surveying in Bosnia and Herzegovina.

Whole Genome Sequence of four samples from COVID-19 outbreaks was done in two laboratories in Bosnia and Herzegovina (Veterinary Faculty Sarajevo and Alea Genetic Center). All four BiH sequences cluster mainly with European ones (Italy, Austria, France, Sweden, Cyprus, England). The constructed phylogenetic tree indicates probable multiple independent introduction events. The success of future containment measures concernig new introductions will be highly challenging for country due to the significant proportion of BH population living abroad.

The bacterial pneumoniae are the significant factor of morbidity and mortality all over the world. So USA are at the sixth place per mortality cause. The bacteria are in 60-80% of cases the causes of pneumonia in the communities. Therefore this is the review on the ethiology of the verification and treatment of pneumonias in the 17-month period in the General hospital "Sarajevo". In the period of the 1st January 2002 till the 31st May 2003 year, it was examined 105 sputa on the antibiogram, and in 12 cases (11.4%) was found the positive bacterial finding. Most often were gram negative bacteria in 7 cases (58.3%), while were found the gram positive in 5 patients (41.7%). Therefore that the majority of the examinees belonged to the risk group, and that were the patients with over 50 years of age 11 (78.6%), with the chronic obstructive lung disease 5 (35.7%), with the malignant disease 1 (7.1%) and with the coinfection of the urinary tract. E. coli was found in 3 patient (25.0%), Kl. Pneumoniae in 2 (16.7%), Ps. aeruginosis in 1 (8.3%), Citrobacter freundi in 1 (8.3%), and in 2 cases (16.7%) were isolated. Staphylococcus intermedius and Streptococcus beta haemolyticus gr. A and Str. Pneumoniae in 1 case (8.3%). To the patients with the positive finding of sputum on antibiogram were most often administered empirically cefalosporia of the third generation because it was about the more severe patients, then the combination of ampicillin with gentamicin. All were dismissed as recovered or in better condition. Pneumonias is in the risk groups are possible to prevent to the five-years pneumococcus vaccine when is indicated or by influenza vaccine when simultaneously was prevented the viral, that is the possible bacterially superinfected pneumonia.

Background and Purpose: Due to the exceptional reactivity of 4-hydroxycoumarin, as well as the versatile biological activity of coumarin derivatives, the synthesis of 3-substituted derivatives of 4-hydoxycoumarin were carried out, and antibacterial and antifungal activity were tested. We assumed that newly-prepared derivatives might have antifungal and antibacterial activity. Material and Methods: Microbiological activity of compounds was tested by the diffusion method on the species of bacteria Escherihia coli 113-1, Pseudomonas aeruginosa ATCC 9027, Staphylococcus aureus SG 511, and fungi Candida albicans ATCC 10231. For comparison of results, the antibacterial activity of currently used antibiotics to the same species ofbacteria was tested. Results: The synthesis of derivatives of 3-cinammoyl-4-hydroxy-coumarin and azomethines of 4-hydroxycoumarin was carried out. Both groups of compounds showed significant microbiological activity. Conclusion: All synthesized compounds showed antimycotic and antibacterial activity. Derivatives of3-cinnamoyl-4-hydroxycoumarin in relation to azomethines of 4-hydroxycoumarin showed better activity in case of all bacteria and fungi species. The best antibacterial activity was shown by the species which had -Cl or -OCH 3 as substituents, and the best antimycotic activity was shown by the species which contained Cl.

Abstract Background: An epidemic of surgical wound infections observed at the State Hospital of Sarajevo during June-September 1992 is reported. Methods: A cross-sectional survey of 138 surgical patients with wound infection treated by the Department of Surgery of the State Hospital of Sarajevo was performed in mid-September and again in mid-November 1992. A preliminary evaluation of the bactericidal effectiveness of a new antiseptic preparation called DI-ASEPT also was done. Results: The frequency of wound infection was 24.4% in September and 19.2% in November. Pseudomonas species was the primary etiologic agent in this epidemic. DI-ASEPT was as effective as povidone-iodine in producing wound asepsis. Conclusions: Because of limited resources large numbers of casualties, and an extremely adverse environment as a result of war that has affected hygienic conditions at the State Hospital of Sarajevo, a high frequency of contaminated or dirty operations were performed. This was the primary reason for the observed increase in wound infections. After hygienic conditions were restored, the epidemic of wound infections was terminated.