Background: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines in nasal mucus may be associated with HRQoL in adolescents with AR. Methods: European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-3L), “The Adolescent Rhinoconjunctivitis Quality of Life Questionnaire” (AdolRQLQ) and the Total 4 Symptom Score (T4SS) scoring system were administered to 113 adolescents with AR, nonallergic rhinitis (NAR) and to healthy control subjects. Nasal secretions were sampled and tested for 13 cytokines using a multiplex flow cytometric bead assay. Results: The AR group had significantly lower EQ-5D-3L (0.661 ± 0.267 vs. 0.943 ± 0.088; p < 0.001) and higher AdolRQLQ total scores (2.76 ± 1.01 vs. 1.02 ± 0.10; p < 0.001) compared to the control group. The AR group had higher concentrations of IL-1β (p = 0.002), IL-6 (p = 0.031), IL-8 (p < 0.001), IL17-A (p = 0.013) and IL-18 (p = 0.014) compared to the control group, and IL-1β, IL-6, IL17-A and IL-18 were significantly (p < 0.050) increased with disease progression. Cytokines IL-1β, IL-6, as well as severe CM, were identified as significant predictors of lower HRQoL in adolescents with AR. Conclusions: This study identified IL-1β, IL-6, as well as severe CM, as predictors of lower HRQoL in adolescents with AR. However, these results should only serve as a starting point for additional confirmation research.

Introduction. The patient and his safety should be at the center of quality health care, which is a challenge for every health system. Adverse patient outcomes (APO) are defined as damage caused by a drug or other intervention in a primary, secondary or tertiary health care facility, which results in a complication of the primary or the emergence of a new disease or injury. The aim of our study was to determine how frequent the APO are, and to determine the differences between nurses and doctors in the frequency, causes and attitudes towards APO. Methods. This cross-sectional study included 100 health professionals, nurses and medical doctors employed at the primary and secondary level of health care. The research was conducted in the period from May to October 2020. The questionnaire was partially taken from a general questionnaire offered on the website of the Agency for Healthcare Research and Quality and the standardized Perceived stress scale was used to measure the degree of subjective stress. Results. Forty-four health professionals (44%) experienced adverse patient outcomes in their career, doctors (52%) significantly more often than nurses (36%) (p = 0.039). More than a half of respondents (52.3%) declared that APO happens few times a month. Seventy percent of the respondents blame their own stress burden as the main factor associated with APO. Doctors more often than nurses (69.2%) blame problems in communication between health professionals as the main cause of APO (27.8%) (p = 0.046). Conclusion. For doctors, the main cause of APO is problem in communication, while nurses more often think that patient safety is priority when compared to doctors. Almost two thirds of respondents blame their own stress burden as a factor associated with APO.

Introduction. Visual-motor integration (VMI) is defined as the degree to which visual perception (VP) and finger-hand movements are well coordinated. The VMI consists of two components: VP and motor coordination (MC). The main goal of our research was to determine whether there are differences in age and gender categories in VMI, VP and MC scores, as well as whether there is a correlation between VMI and school success of younger school-aged children. Methods. Out of 103 student respondents, 52 were female (50.5%), aged 6 to 11 years (8.05 ± 1.44 years), divided into two groups according to age: 6-8 years (first, second and third grade) and 9-11 years (fourth to fifth grade). Data on the level of VMI were obtained by applying the following tests: Beery-Buktenica Developmental Test of VMI, VP test and MC test. Results. In the older age group of subjects, a significant difference was observed in the mean values of the score on the VMI (12.67 ± 1.92), VP (23.69 ± 3.21) and MC (24.34 ± 3.23) tests comparing to the younger group of subjects (9.98 ± 2.12; 20.80 ± 3.2; 19.65 ± 3.82) (p < 0.001), while the difference in the mean values of scores in relation to gender was not observed. A significant, positive and strong correlation was observed between the scores on the VMI, VP and MC test with the success of second to fifth grade students (p < 0.050). Conclusion. Given such a strong correlation between VMI and the success of younger students, we conclude that it is important that VMI disabilities are identified in time, so that these students can be referred for further assessment and receive the necessary support.

The focus of this text is twofold. The first task is to reconsider the mode of interpretation of various small (4 to 10 cm) objects (axes, chisels, finger-rings, pendants), made of green minerals – jadeite and/or nephrite. These objects are registered on 15 sites in the territory of present-day Serbia, dated into the Neolithic period (6200/6000–4600/4500 cal BC). The second task is to lay out a short history of the green colour. As stated by Michel Pastoureau (Pasturo 2015), the production of a green pigment was almost impossible in the past, especially in praehistory. The first recorded attempts are linked to Ancient Egypt, and the oldest successful production of the green pigment is dated to Ancient Rome. Therefore, the text examines the symbolic role of these small green objects during the Neolithic. The beds of green minerals jadeite and nephrite are not recorded in the territory of Serbia. Jadeite may be found south of Skopje (Mt. Solunska glava), in the Cyclades in Greece, as well as in the Piedmont Alps. Nephrite is registered in the mountain Ogražden (SW Bulgaria), in Poland, Sweden, and Italy. The absence of mineral layers in the region surely suggests the existence of long-distance exchange. This raises the issue of the role and symbolic function of these objects – what was their appeal for the past communities and what was the role of their colour in their manufacture? In archaeology, the studies in symbolics of various colours are rare. Authors have mainly focused upon the origin of the colour and the dating of the objects, but the role of the colour itself as the criterion in choosing various raw materials has largely been neglected. Notable is the exception of the thematic collection “Colouring the Past: The Significance of Colour in Archaeological Research” (2002), where attempts have been made to explain the symbolic importance of various colours in the past. However, the colour green is not mentioned. This paper does not aim to offer final solutions, but to investigate the usage and importance of the colour green on the grounds of the usage of the objects themselves.

Introduction. Inhalation of coal dust during blasting in brown coal mines has been shown to lead to a lung disease called pneumoconiosis. There is very little data in the literature on the direct impact of coal on the quality of life of people who work in coal mines as well as the body's immune response to the effects of coal dust. The aim was to examine the immune response to exposure to coal dust in miners in a brown coal mine and whether mine workers have poorer quality of life compared to those not exposed to coal dust. Methods. This is a cross-sectional study among 100 employees in the Brown Coal Mine in Ugljevik, of which 50 of them are exposed to coal dust on a daily basis. Blood samples were taken from all subjects to test for the presence of cytokines IL-2, 4, 5, 9, 10, 13, 17A, 17F, 21, 22, IFN-g and TNF-a. The quality of life of employees was measured using a questionnaire for self-assessment of physical and mental health (36-item Short-Form Health Survey, SF-36). Results. Group of miners had a significantly (p<0.05) higher concentrations of pro-inflammatory cytokines IL-6, IFN-g, IL-17A and IL-22 when compared to the control group. Subjects from the control group had significantly (p<0.05) higher concentrations of anti-inflammatory cytokines IL-4 and IL-10 when compared to the group of miners. The quality of life was significantly (p<0.05) better in the control group when compared to the group of miners. Conclusion. Physical functioning, general health, mental health and Physical component summary were significantly poorer in the group of miners. Exposition to coal dust led to a significant increase in the production of pro-inflammatory cytokines and a decrease in the production of anti-inflammatory cytokines.

Pojmovnik kamenog doba, Ivor Karavanic (ur.), Nikola Vukosavljevic, Rajna Sosic Klindžic, Tihomila Težak-Gregl, Josip Halamic, Tomislava Bosnjak Botica, Bruno Nahod, 2015, Zagreb: Sveuciliste u Zagrebu, Filozofski fakultet – FF Press – Institut za hrvatski jezik i jezikoslovlje. Zagreb, 338 str.

Uvod. Tinitus se definise kao percepcija zvuka u usima ili glavi bez prisutnih vanjskih izvora zvuka. Zujanje u uhu i nesposobnost bolesnika da se prilagode ovoj pojavi može da dovede do ispoljavanja emocionalnih tegoba, kao sto su depresija i anksioznost. Cilj ove studije je bio da se procijeni stepen depresivnih tegoba koje prate hronicni tinitus i ispita veza između prisustva tinitusa i simptoma depresije kod pacijenata sa hronicnim subjektivnim tinitusom. Metode. Studijom su obuhvacena 73 bolesnika sa tinitusom i 47 ispitanika bez tinitusa, a obje grupe su uparene po polu i uzrastu. Bolesnici su podvrgnuti otorinolaringoloskom pregledu i popunili su samostalno Tinitus hendikep upitnik i Beck-ov upitnik depresije. Tonalna liminarna audiometrija je urađena kod obje grupe ispitanika. Rezultati. Audioloskim ispitivanjem je otkriveno da 7 (9,6%) bolesnika sa tinitusom nema ostecenje sluha, a vecina (41-56,2%) je imalo nagluvost lakog stepena, dok je među ispitanicima bez tinitusa 28 (59,6%) imalo normalan sluh. Bolesnici su najcesce imali visoke frekvencije tinitusa (63-86,3%), a u odnosu na intenzitet 48 (65,8%) bolesnika je imalo srednje jak tinitus (5-20 dB). Tinitus hendikep upitnikom dobijen je skor koji je klasifikaovao subjektivni doživljaj hendikepa kao zanemarljiv kod 26 (35,6%) bolesnika, blag kod 12 (16,4%), umjeren kod 23 (31,5%), težak kod 7 (9,6%) i veoma težak kod 5 (6,8%) bolesnika. Beck-ovim upitnikom depresije utvrđeno je normalno raspoloženje kod 59 (80,8%) bolesnika, odnosno kod 43 (91,5%) ispitanika bez tinitusa (U=1282.0, Z=-2.35, p<0,05). Između skorova dobijenih koriscenjem ova dva upitnika utvrđen je visok stepen korelacije (ρ=0,436, p<0,001). Zakljucak. Znacajna korelacija između skorova dobijenih Tinitus hendikep upitnikom i Beck-ovim upitnikom depresije ima znacaja u pristupu lijecenju ovih bolesnika. Kako depresija dodatno smanjuje kvalitet života, neophodno je da se adekvatnim tretmanom utice na bržu adaptaciju na tinitus.