The aim of the research was to determine whether the age of the patient affects the duration of the procedure and the amount of ionizied radiation delivered when performing diagnostic coronary angiography. The research was conducted at the Clinic for Invasive Cardiology of the Public Health Institution "University Clinical Center" Tuzla in the period from December 2018. to January 2020. The research included a total sample of 240 respondents, average chronological age of 62.60 ± 9.22 years, ranging from 24 to 85 years. Out of a total of 240 respondents, in 121 respondents coronarny angiography was performed using transradial arterial approach and 119 by performing a transfemoral arterial approach. The total sample was divided into two subsamples of respondents. The first sub-sample consists of respondents up to 65 years of age, and the second sub-sample consists of respondents over 65 years of age. During each performance of coronary angiography, the duration of the procedure (in minutes and seconds) and the amount of radiation delivered during the procedure (in mGy) were measured. The research data were processed using the method of parametric and non- parametric statistics. The Mann-Whitney U test was used to verify the research objective. Based on the obtained research results, it can be concluded that in patients over 65 years of age, the duration of the coronary angiography procedure is longer, and is at the limit of statistical significance (p= 0.057). The amount of delivered radiation is higher in respondents over 65 years of age, but it is not statistically significant (p= 0.396). Keywords: Coronary angiography, coronary disease, procedure duration, age, amount of delivered radiation.

The aim of the study is to present and tune a fully automatic deep learning algorithm to segment colorectal cancers (CRC) on MR images, based on a U-Net structure. It is a multicenter study, including 3 different Italian institutions, that used 4 different MRI scanners. Two of them were used for training and tuning the systems, while the other two for the validation. The implemented algorithm consists of a pre-processing step to normalize and to highlight the tumoral area, followed by the CRC segmentation using different U-net structures. Automatic masks were compared with manual segmentations performed by three experienced radiologists, one at each center. The two best performing systems (called mdl2 and mdl3), obtained a median Dice Similarity Coefficient of 0.68(mdl2) - 0.69(mdl3), precision of 0.75(md/2) - 0.71(md/3), and recall of 0.69(mdl2) - 0.73(mdl3) on the validation set. Both systems reached high detection rates, 0.98 and 0.95, respectively, on the validation set. These encouraging results, if confirmed on larger dataset, might improve the management of patients with CRC, since it can be used as a fast and precise tool for further radiomics analyses. Clinical Relevance - To provide a reliable tool able to automatically segment CRC tumors that can be used as first step in future radiomics studies aimed at predicting response to chemotherapy and personalizing treatment.

Various toxic heavy metals have become hazardous to human health as well as the environment. This research has been focused on a biosorption/bio-removal process of chromium (III), copper (II) and lead (II) ions from an aqueous solution by utilizing lignocellulosic biomass of Citrus limon peel (CLP) powder. CLP powder biomass was selected based on dietary fibre components having greater potential to remove target heavy metal ions in order to purify wastewater by following the eco-friendly biosorption method. At optimum conditions, the observed maximum removal efficiency of 97.47, 87.13 and 95.71% for Cr, Cu and Pb ions, respectively, was observed. An investigation has been made as a work of pH, CLP amount and temperature. The presented bio-removal processes by prepared CLP biosorbent manifested as a temperature-independent. Langmuir isotherm model was found an excellent fit of the isotherm data for tested systems with the calculated biosorption capacities of 111.11 (Cr), 76.92 (Cu) and 100.00 (Pb) mg/g. The positive ΔH values for selected target heavy metal ions, except lead ions, confirmed that the reaction was spontaneous and endothermic. A cooperative mechanism of second-order and intraparticle diffusion models during the adsorption processes of all three target ions was established with a higher coefficient of determination and more closely anticipated take-up (adsorption capacity). Furthermore, the interaction of -OH and -COOH functional groups of CLP that have a major role in the removal of Cr, Cu and Pb ions from single-ion aqueous solution and/or a surface biosorption was confirmed based on the results presented by SEM-EDS and FTIR analysis. Analysis from XRD revealed peak corresponding to amorphous cellulose type I as observed by FT-IR analysis.

Mobility is a key aspect of modern networking systems. To determine how to better manage the available resources, many architectures aim to a priori know the future positions of mobile nodes. This can be determined, for example, from mobile sensors in a smart city environment or wearable devices carried by pedestrians. If we consider infrastructure networks, frequently changing the coverage cell may lead to service disruptions if a predictive approach is not deployed in the system. All predictive systems are based on the storage of old mobility samples to adequately train the model. Our focus is based on the possibility to determine an approach for adaptively sampling mobility patterns based on the intrinsic features of the human/node behavior. Several works in the literature examine mobility prediction mobile networks, but all of them are dedicated to the study of time features in mobility traces: none took into account the spectral content of historical mobility patterns for predictive purposes. In contrast, we take into account this spectral content in mobility samples. Through a set of wavelet transforms, we adapted the sampling frequency dynamically and obtained a considerable set of advantages (space, energy, accuracy, etc.). In fact, this issue covers an important role in the IoT paradigm, where energy consumption is one of the main variables requiring optimization (frequent and unnecessary mobility samplings can disrupt battery life). We performed several simulations using real-world traces to confirm the merit of our proposal.

Analysis of mechanical stability for external fixation device Orthofix in the case of anterior-posterior bending is carried out in this paper. Device is applied to the lower leg for the case of unstable fracture. Real device is mea sured and 3D CAD model is developed. CAD model is used for numerical structural stress analysis which is car ried out using CATIA V5 software. Results for displacements are obtained for selected critical places on the device and for the place of fracture. In addition, values of principal and von Misses stresses are obtained and analyzed. Using obtained results, conclusions about mechanical stability of device are formulated.

The paper analyzes the stiffness of the Orthofix external fixation system at axial pressure load, applied to the lower leg in case of an unstable fracture. Based on the actual construction of the Orthofix fixator, its 3D model was formed, and then a structural analysis was performed in the CATIA V5 software system. The aim of this paper is to investigate the mechanical properties of Orthofix fixator. FEM analysis of the fixator revealed displacements at characteristic points of the structure and fractures. During the FEM analysis, it is possible to change the load values, all with the aim of obtaining the best possible information about the behavior of the fixator during installation and use by the patient. Based on the results obtained from the FEM analysis, it can be concluded that the Orthofix fixative shows very good stiffness, but also that it can be improved by using newer materials, such as composite or some alloys of titanium and aluminum.

The paper aimed to examine if the mechanical characteristics (tensile strength, elongation, and friction) of the selected flexible packaging materials (BOPP and PET/PE) change after the packaging process. Some researchers have shown that mechanical characteristics can change because of the various effects to which foils are exposed (temperature, transport devices, solvents, etc.). The measurement of tensile strength and elongation was carried out according to SRPS G.S2.734, and the measurement of friction according to ASTM D 1894. The results show that there were no significant changes in the examined mechanical characteristics that could affect the functionality of the packaging.

Ugledna talijanska izdavačka kuća Mucchi iz Modene u rujnu 2021. godine, pod uredničkom palicom Antonija Saccoccija, redovitog profesora Sveučilišta La Sapienza u Rimu, i Stefana Porcellija, višeg istraživača Sveučilišta u Bresciji, objavila je znanstvenu monografiju pod nazivom Kineski građanski zakonik i rimski pravni sustav (Codice civile cinese e sistema giuridico romanistico). Riječ je o monografiji za kojom se, očekivano, javio veliki interes u romanističkim krugovima, ali i među širom zainteresiranom pravničkom javnošću. Naime, 1. siječnja 2021. godine u Narodnoj Republici Kini, najmnogoljudnijoj i jednoj od ekonomski najsnažnijih zemalja svijeta, stupio je na snagu novi Građanski zakonik (Codex iuris civilis sinicus, dalje: Zakonik), koji je 28. svibnja 2020. godine usvojio Državni narodni kongres Kine. Težnja za uređenjem pravnog sustava, poštujući princip vladavine prava u Kini, prisutna je posljednjih nekoliko desetljeća. U segmentu privatnog prava bili su prisutni veliki napori i različiti iskoraci u cilju uređenja mnogih pitanja značajnih za kinesko društvo u cjelini. Došlo je do usvajanja Zakona o dioničkim društvima, Zakona o ugovorima, Zakona o vlasništvu i stvarnim pravima itd. Pravni znanstvenici koji su pratili te izmjene, poput jednog od urednika predmetne monografije, Stefana Porcellija, ocijenili su kako su revizije ovih zakona bile prilično značajne i temeljite te su se ticale mnogih segmenata duboko vezanih s istinskim potrebama kineskog društva. Donošenje svih tih zakona te kontinuirani rad na modifikacijama unutar pravnog poretka dodijelio je novim zakonima središnju ulogu u kineskom društvu. Iako su nedvojbeno reformski procesi doprinosili jačanju vladavine prava, nastojeći uspostaviti vertikalni niz između kineske prošlosti, sadašnjosti i budućnosti, sve se izvjesnijom činila nužnost kodificiranja prava. Prijedlozi za izradu Zakonika spominjali su se još prije 20-ak godina, ali zauzet je opći stav kako društvo, ako se savinjistički izrazimo, još uvijek nije zrelo za cjelovitu reformu. I tako, nastavljen je niz donošenja novih zakona, što je zbog velike količine propisa uzrokovalo nužnost sustavnog usklađivanja kako bi se ti propisi mogli razumjeti i primijeniti. Zbog svega navedenog u listopadu 2014. godine Središnji odbor Komunističke partije Kine izrazio je želju da se izradi Nacrt građanskog zakonika za Narodnu Republiku Kinu. Radovi na izradi kodifikacije napredovali su velikom brzinom, a u tom procesu došlo je do snažne, u prvom redu akademske, suradnje kineskih i talijanskih pravnika. Na tom tragu rimsko pravo i moderne građanske kodifikacije, osobito talijanski Codice civile, poslužili su kao izvrsni modeli iz kojih se crpila pravnička inspiracija, a sve kako bi se, poštujući pravila o pravnoj transplantaciji, instituti i koncepti na adekvatan način inkorporirali u kinesku pravnu kulturu i omogućili joj daljnji gospodarski rast i razvoj, što je nedvojbeno u korelaciji s osiguranjem pravne sigurnosti. Zakonikom je postavljen cilj osiguravanja pravde kroz reguliranje građanskih, trgovačkih, a jednim dijelom i radnih odnosa, kroz sustavno pružanje jasnog pravnog okvira onima koji posluju ili žele poslovati na području Kine. Kako su sami urednici naglasili u uvodnoj studiji, forma i koncepti predmetne kodifikacije pokazuju kako je kineski zakonodavac i tamošnja pravna znanost prilikom izrade kodifikacije nastojala postići dijalog s rimskim pravnim sustavom, odnosno pravničkim poukama izgrađivanim u rimskoj pravnoj tradiciji posljednjih tisućljeća. Zbog toga, kako bi se istinski razumjeli opsezi primjene i izvorna značenja koncepata primijenjenih u Zakoniku, nužno je, u cilju razumijevanja sadržaja, dobro poznavati te konstantno proučavati rimski pravni sustav i njegov unutarnji razvoj.

We analyze $K\to \pi \nu\bar \nu$ rates in a model with a TeV-scale leptoquark addressing $B$-meson anomalies, based on the flavor non-universal 4321 gauge group featuring third-generation quark-lepton unification. We show that, together with the tight bounds imposed by $\Delta F = 2$ amplitudes, the present measurement of $\mathcal{B}(K^+ \to \pi^+ \nu \bar\nu)$ already provides a non-trivial constraint on the model parameter space. In the minimal version of the model, the deviations from the Standard Model in $\mathcal{B}(K^+ \to \pi^+ \nu \bar\nu)$ are predicted to be in close correlation with non-standard effects in the Lepton Flavor Universality ratios $R_D$ and $R_{D^*}$. With the help of future data, these correlations can provide a decisive test of the model.

We introduce the first IJMS World Conference of Medical Student Research as a unique opportunity for medical students and early-career scientists around the globe to share the results of their research in an online worldwide platform, aimed at increasing accessibility to research for medical students and creating bonds of collaborations between participants and future scientists and leaders of medical research education. This is also the second issue of the 10-year anniversary of the Journal, and we describe in summary the published research and experiences of this issue. 

By presenting the contemporary intercultural, interreligious, and peace dialogue in the space and place of Jerusalem and the more general Israel-Palestine conflict, attempting to remain outside the mainstream political framework, the paper examined sociopolitical-religious synergy and partially, critical human securitization. Interculturalism, multiculturalism, and such notions emerged in the 1970s, emphasizing different cultures' equivalence and dialogue. Besides cultural and territorial determinants of Arab-Israeli conflict, the status quo is conditioned by a religious rather than a secular approach to political organization. Both civilizations, peoples view the area they inhabit through religious rights, turning history into theology and different theology into sociopolitics. It presents a human conflict. While religion and nationalism based on power have often contributed to antagonism, violence, and wars, the objectives of the three monotheist religions addressing peace suggest a shift towards mutual compromise from hegemonic visions to practical expectancies. Jerusalem is the holy place where all confessions have the right of residence. Infiltration of faith into this political dispute, Islamism, and Judaism is a religious aspect disputed between Jews and Arabs. Conflicts are mainly due to territory, and religion gives it a higher purpose within narratives regarding supernatural rights. Despite the inter-religious tensions and passions involved in the contradictory faith elevation at this religious source, the internal and external peace is influenced by politics. The holy Jerusalem has been perpetual - the case. Many unadulterated Jews, Catholics, and Palestinians, who desire the city's lasting security, should be more willing to compromise. The future sociopolitical life must work around healthy economic development and human security. The revenge paradigm could negatively influence sustainable peace, maintaining violence and hybrid wars within social, psychological, historical, cultural, and stagnation reasons. There is a comparable paradigm in the Balkans- Bosnia to Israel-Palestinian question, where similar policies maintain and clerical, national, and ethnopolitical patterns materialize, i.e., critical peace stalemate persists.

Key Points The aptamer rondoraptivon pegol improved VWF/FVIII levels, multimer patterns, and thrombocytopenia in type 2B von Willebrand disease. Once weekly subcutaneous injections of rondoraptivon pegol may in the future be used for prophylaxis or treatment of VWD.

The aim of this study was to examine the frequency of consumption of coffee beverages in the city of Mostar. In 2019, an analysis of caffeine content was performed on HPLC in 10 different samples of coffee beverages. Samples of coffee were taken from the market of the city of Mostar by random selection. In addition to the High-performance liquid chromatography (HPLC) method, the study was conducted using empirical and descriptive methods. An assessment of daily (EDI) and weekly intake (EWI) was also performed were on the base of determined values of caffeine content in 10 different coffee samples. The acute toxic dose of caffeine is not well defined, but it is considered more than 10 grams of caffeine per day for adults, while in most countries it is not recommended that more than 450 mg of caffeine be consumed per day. The samples were found to be in accordance with the EFSA Scientific Opinion (European Food Safety Authority) stating that a single dose of 200 mg of caffeine from all sources does not pose a risk to the health of healthy adults. (EFSA, 2015).

In this paper the first record of the alien mantis species Hierodula tenuidentata for Bosnia and Herzegovina is provided. This large mantis has considerably expanded its distribution range in Europe in the last years, particularly in Balkan Peninsula. We found several adult specimens on 22nd and 23rd of August 2021 in urban area of Mostar city in the south of the country. This finding confirms the species’ establishment in the western part of Balkan Peninsula and fills the distribution gap along the eastern Adriatic Sea coast.