Abstract In today’s increasingly connected and digitized business environment, brands face numerous challenges that can significantly affect their reputation and value, and one of the key challenges that many organizations across the world face is brand risk. Due to its role in many aspects of business, the main purpose of this paper is to revitalize this phenomenon by exploring it through bibliometric indicators, publishing trends and analyzing it through the current literature. In this sense, the paper adresses two research questions, both related to revealing the scope and nature of brand risk as the construct of a great relevance in many scientific fields, whereas a special attention has been given to the analysis of the most cited papers on this matter. The findings show that the construct although presented two decades ago is still in infancy phase, and quite neglected in the current body of knowledge.

The primary goal of this research was to determine the differences in kinematic parameters between the first and second serves in tennis among the elite players of the German league. The sample of respondents in this research consisted of 30 elite male senior players of the German League who have "Leistungklasse" from 1 to 7. The kinematic parameters that were analyzed are: Height of ball impact (KPVUL), Racket speed (KPBRE), Ball speed (KPBLO), The angle at the elbow joint of the arm that hits the ball (KPULZ), Oscillation of the vertical projection of the center of gravity of the body (KPOVP), Jump height (KPVSK), Ball launch height (KPVIL), The point of contact between the ball and the racket "sweetspot" (KPMLR), Ball rotation "Top spin" (KPRLO). The video recording required for kinematic analysis was acquired with two Casio EX-F1 digital cameras at a frequency of 200 images per second. The camera was placed at an angle of 900 in relation to the recording plane, and they were at a distance of 10 m. Space calibration was performed with the help of a calibration frame (200 x 200 cm). We have installed Zepp Tennis Smart Sensor 2.0 in the handle of the Wilson Pro Staff RF97 Autograph racket, using the Zepp Tennis application software. "Kinovea" software was used for service analysis and obtaining kinematic parameters from video recordings. By analyzing the results of the T-test for independent samples, it can be seen that there are statistically significant differences in five of the nine analyzed kinematic parameters : KPBRE – kinematic parameter of racket speed (Sig.=.000), KPBLO – kinematic parameter of ball speed (Sig.=.000), KPULZ – kinematic parameter angle in the elbow joint (Sig.=.000), KPMLR – kinematic parameter point of contact between the ball and the racket (Sig.=.000), as well as a variable KPRLO – kinematic parameter of ball rotation (Sig.=.000). Larger numeric values in variables: KPVUL – kinematic parameter ball impact height, KPOVP – kinematic parameter of oscillation of the vertical projection of the center of gravity of the body, KPVSK – kinematic parameter jump height and KPVIL – kinematic parameter ball impact height, show a difference but it is not enough to be statistically different. Key words: tennis, kinematic analysis, racket speed, Zepp sensor

Objective: To investigate the arterial stiffness and risk factors in adolescence. Arterial stiffness often (AS) results from the degenerative process of the media layer of elastic arteries causing rigidity of the arteries. Arterial stiffness increases with age and it is associated with several risk factors as a disease predictor. But, arterial stiffness can be also increased in a healthy arteries as well. The increased sympathetic activity promotes vasoconstriction of resistant blood vessels i.e. arteries and arterioles that result in peripheral vasoconstriction. Adolescence age is the most important period of life for promoting future health. The certain dynamic risk factors in adolescence like, emotional dysregulation, psychological family stress, education pressure, lack of sleep, gambling, substance abuse, smartphone overuse and obesity can cause arterial stiffness. Design and method: The prospective open randomized study was designed. Adolescence age between 10 and 19 years have been investigated for increased arterial stiffness and risk factors. The inclusion criteria was healthy adolescence, while exclusion criteria was any disorder present. Arterial stiffness, non-invasive blood pressure and pulse wave datas have been measured using Agedio device. The risk factors were evaluated in every subject. The vascular age have been outlined as the final measure. Results: The preliminary results indicate the increase of Augmentation Index and Coefficient of Reflection. The average percentage of Augmentation Index was 40% and Coefficient of Reflection 65% (normal value 28% and 60% respectively). The main risk factors were educational pressure, lack of sleep and smartphone influence. The vascular age was on average, 3 years higher than biological age. Conclusions: Arterial stiffness in adolescence is increased mainly by peripheral vasoconstriction, manifested with Augmentation index and Coefficient of wave Reflection.

Background: Colorectal cancer (CRC) is a diverse disease with various clinical, pathological and molecular features that affect tumor biological behavior, treatment response and prognosis. Objective: The aim of this study was to evaluate the correlation between metabolic 18F-FDG PET/CT parameters (SUVmax, MTV and TLG) and CEA in recurrent and metastatic CRC and to evaluate prognostic value of metabolic 18F-FDG PET/CT parameters in recurrent and metastatic CRC. Methods: A descriptive study of 100 patients with previously detected and surgically treated CRC referred to PET/CT with a suspicion of recurrent or metastatic CRC. CEA was measured within three months from the imaging. A low-dose PET/CT was performed per institutional protocol. For each hypermetabolic lesion, metabolic PET/CT parameters (SUVmax, MTV, TLG) were calculated semiautomatically. Pathohistology or clinical data from the follow-up were used as the gold standard. Sensitivity, specificity, PPV and NPV for 18F-FDG PET/CT and CEA in detection of recurrent or metastatic CRC were calculated. Correlation between CEA and SUVmax, MTV and TLG was calculated, separately. To assess the prognostic values of metabolic parameters in CRC, survival analysis with 18-month progression-free survival (PFS) as an endpoint was performed. Microsoft Excel sheets, ROC and Kaplan-Meier curves were used to present the data. Logrank and Tarone-Ware test and Cox model of proportional hazards were used to compare the groups. Results: Study included 100 patients, 45 males and 55 females, age range 36-81 years, mean age 61,4 years. Cancer site was colon in 56% and rectum in 44%. Sensitivity, specificity, PPV and NPV of 18F-FDG PET/CT in detection of recurrent or metastatic CRC was 95%, 73%, 70% and 95%, respectively. Sensitivity, specificity, PPV and NPV of CEA in detection of recurrent or metastatic CRC was 58%, 96%, 91% and 78%, respectively. SUVmax, MTV and TLG positively correlated with CEA, but only CEA-TLG correlation was considered significant (r=0,67). The regression model analysis revealed: SUVmax (HR=0,63, 95%CI=0,28-1,41, p=0,214), MTV (0,59, 95%CI=0,28-1,22, p=0,111) and TLG (HR=0,45 95%CI=0,21-0,99, p=0,028), and the prognostic role in CRC was proven for TLG only. Conclusion: Metabolic 18F-FDG PET/CT parameters may have the prognostic value in CRC, but further multicentric prospective studies are required for validation.

Cyber-physical systems are taking on a permanent role in the industry, such as in oil and gas or mining. These systems are expected to perform increasingly autonomous tasks in complex settings removing human operators from remote and potentially hazardous environments. High autonomy necessitates a more extensive use of artificial intelligence methods, such as anomaly detection, to identify unusual occurrences in the monitored environment. The absence of data characterizing potentially hazardous events leads to disruptive noise displayed as false alarms, a common anomaly detection issue for hazard identification applications. Contrastingly, disregarding the false alarms can result in the opposite effect, causing loss of early indications of hazardous occurrences. Existing research introduces simulating and extrapolating less represented data to expand the information on hazards and semi-supervise the methods or by introducing thresholds and rule-based methods to balance noise and meaningful information, necessitating intensive computing resources. This research proposes a novel Warning Identification Framework that evaluates risk analysis objectives and applies them to discern between true and false warnings identified by anomaly detection. We demonstrate the results by analyzing three seismic hazard assessment methods for identifying seismic tremors and comparing the outcomes to anomalies found using the unsupervised anomaly detection method. The demonstrated approach shows great potential in enhancing the reliability and transparency of anomaly detection outcomes and, thus, supporting the operational decision-making process of a cyber-physical system.

Is it safe to have a pregnancy in women with prior history of hormone receptor-positive early breast cancer? Pregnancy following breast cancer treatments in young women with history of hormone receptor-positive disease is safe with no detrimental effect on patients’ prognosis. Breast cancer is the most common malignancy diagnosed in women of reproductive age. Both physicians and patients continue to have concerns about a potential detrimental effect of pregnancy after breast cancer, particularly in the setting of hormone receptor-positive disease. In recent years, several studies have demonstrated the safety of pregnancy after anticancer treatments in breast cancer survivors. A systematic literature search of Medline, Embase and Cochrane library with no language or date restriction up to January 1st, 2023, was performed following the PRISMA guidelines. We included retrospective or prospective case-control and cohort studies as well as prospective clinical trials comparing survival outcomes of premenopausal female patients with reported pregnancy or not after diagnosis and treatment for hormone receptor-positive breast cancer. Included patients were childbearing potential age women with a prior history of hormone receptor-positive early breast cancer. Outcomes of interest were disease-free survival and overall survival. Hazard ratios (HR) with 95% confidence intervals (CI) were extracted. Higgins I2 index was used to evaluate the degree of inconsistency in the results of the included studies. Pooled HRs were considered statistically significant with a P value of < 0.05 (two-sided). Eight studies were eligible to be included in the final analysis. A total of 3,805 patients with hormone receptor-positive breast cancer were included in these studies, of whom 1,285 had a pregnancy after treatments. Median follow-up of the included studies ranged from 3.81 years to 15.8 years. In three studies (n = 987 patients) reporting on disease-free survival outcomes, no difference was observed between patients with or without a subsequent pregnancy (HR 0.96, 95% CI 0.75 – 1.24, p = 0.781). Six studies (n = 3,504 patients) reported outcomes in terms of overall survival: patients with a pregnancy after breast cancer had better overall survival compared with those without a pregnancy (HR 0.46, 95% CI 0.27 – 0.77, p < 0.05). At the subgroup analysis on timing of pregnancy, no detrimental effect of pregnancy after breast cancer in terms of disease-free survival was observed for patients achieving a late pregnancy (defined as 2 or 5 years after diagnosis) as compared to patients without a subsequent pregnancy (HR 1.08, 95% CI 0.80 – 1.46, p = 0.611). Increased disease-free survival was observed in patients with an early pregnancy (HR 0.63, 95% CI 0.47 – 0.85, p < 0.05). This meta-analysis is based on abstracted data and most of the studies are retrospective cohort studies. Median follow-up in a large proportion of the studies was shorter than 10 years. Adjuvant hormone therapy before and after pregnancy was not available in many studies included. Our results strengthen the evidence that having a pregnancy in women with prior history of hormone receptor-positive breast cancer is safe. not applicable

Connected, Cooperative, and Autonomous Mobility (CCAM) will take intelligent transportation to a new level of complexity. CCAM systems can be thought of as complex Systems-of-Systems (SoSs). They pose new challenges to security as consequences of vulnerabilities or attacks become much harder to assess. In this paper, we propose the use of a specific type of a trust model, called subjective trust network, to model and assess trustworthiness of data and nodes in an automotive SoS. Given the complexity of the topic, we illustrate the application of subjective trust networks on a specific example, namely Cooperative Intersection Management (CIM). To this end, we introduce the CIM use-case and show how it can be modelled as a subjective trust network. We then analyze how such trust models can be useful both for design time and run-time analysis, and how they would allow us a more precise quantitative assessment of trust in automotive SoSs. Finally, we also discuss the open research problems and practical challenges that need to be addressed before such trust models can be applied in practice.

This study is established on the aim to analyse a game and determine differences in a shot efficacy in an offence the woman’s handball national teams at the Olympic games in Tokyo 2021. Four national teams were analysed: France, Russia, Norway and Sweden. To analyse a game in the offence, 12 variables were used: total number of shots (sut_uk), efficient number of shots (sut_usp), total number of shots from 6 meters (sut_m6_uk), efficient number of shots from 6 meters (sut_m6_us), total number of shots from wings (sut_kril_uk), the efficient number of shots from wings (sut_kr_us), total number of shots from 9 meters (sut_m9_uk), efficient number of shots from 9 meters (sut_m9_us), total number of shots from 7 meters (sut_m7_uk), efficient number of shots from 7 meters (sut_m7_us), total number of fast centres (brzc_uk) and total number of efficient fast centres (sut_brzc_us). All national teams had the approximal number of efficient shots on a goal. The highest number of efficient shots from 6 m had the French and Norwegian national teams. From the wing position, the highest number of efficient shots had the Norwegian national team, while the lowest number of efficient goals from the wing position had the Russian national team. The Norwegian and French national teams were approximately efficient in the shot’s realisation from 9 m. In a realisation of the fast centre, the Russian national team stands out with the highest number and the French national team had the lowest number of efficient shots. Key words: cumulative analysis, handball, woman, shooting accuracy, efficiency,Olympic games

Background In last two decades, there have been substantial changes in the pattern of lipid-modifying medicines utilisation following the new treatment guidelines based on clinical trials. The main purpose of this study was to analyse the overall utilisation and expenditure of lipid-modifying medicines in the Republic of Srpska, Bosnia and Herzegovina during an 11-year follow-up period and to express its share in relation to the total cardiovascular medicines (C group) utilisation. Methods In this retrospective, observational study, medicines utilisation data were analysed between 2010 and 2020 period using the ATC/DDD methodology and expressed as the number of DDD/1000 inhabitants/day (DDD/TID). The medicines expenditure analysis was used to estimate the annual expenditure of medicines in Euro based on DDD. Results During the analysed period, the use of lipid-modifying medicines increased almost 3-times (12.82 DDD/TID in 2010 vs 34.32 DDD/TID in 2020), with a rise in expenditure from 1.24 million Euro to 2.15 million Euro in the same period. This was mainly driven by an increased use of statins with 163.07%, and among these, rosuvastatin increased more than 1500-fold, and atorvastatin with 106.95% increase. With the appearance of generics, simvastatin showed a constant decline, while the other lipid-modifying medicines in relation to the total utilisation had a neglecting increase. Conclusion The use of lipid-modifying medicines in the Republic of Srpska has constantly increased and strongly corresponded to the adopted treatment guidelines and the positive medicines list of health insurance fund. The results and trends are comparable with other countries, but still the utilisation of lipid-lowering medicines represents the smallest share of total medicines use for the treatment of cardiovascular diseases, compared to high-income countries.

A design concept of phase-separated amorphous nanocomposite thin films is presented that realizes interfacial resistive switching (RS) in hafnium-oxide-based devices. The films are formed by incorporating an average of 7% Ba into hafnium oxide during pulsed laser deposition at temperatures ≤400°C. The added Ba prevents the films from crystallizing and leads to ∼20-nm-thin films consisting of an amorphous HfOx host matrix interspersed with ∼2-nm-wide, ∼5-to-10-nm-pitch Ba-rich amorphous nanocolumns penetrating approximately two-thirds through the films. This restricts the RS to an interfacial Schottky-like energy barrier whose magnitude is tuned by ionic migration under an applied electric field. Resulting devices achieve stable cycle-to-cycle, device-to-device, and sample-to-sample reproducibility with a measured switching endurance of ≥104 cycles for a memory window ≥10 at switching voltages of ±2 V. Each device can be set to multiple intermediate resistance states, which enables synaptic spike-timing–dependent plasticity. The presented concept unlocks additional design variables for RS devices.