The aim of this study is to determine the differences between the medallists and non-medallists in male and female artistic gymnastics at the Olympic Games from 1996 to 2016. Basic procedures: Data concerning the athletes were obtained from the “Official documents of the International Olympic Committee” which include the athlete’s date of birth and date of competing. The total number of analysed OG participants in men’s artistic gymnastics amounted to n = 419 and the women’s artistic gymnastics was n = 417. Main findings: With men the t test for small independent samples has determined statistically significant differences between medallists and other competitors in 2000 and 2012. Among women no significant statistical differences have been found in all the mentioned variables. Conclusions: The differences between male medallists and non-medallists are manifested through the age of the competitors: 2.57 years in 2000 and 3.57 years in 2012. Compared to other OG a higher level of homogeneity and smaller age difference is noticeable. In difference to men, women had no similar differences within a period of 20 years. In artistic gymnastics in the last couple of years there is a recurring trend of a late specialisation because with each new scoring Code of Points the conditions demanded from the competitors become harder.

Introduction/Objective: The efficacy and safety of bevacizumab (BEV) in combination with capecitabin and irinotecan in first-line therapy of patients with metastatic colorectal cancer (mCRC) were studied. In order to improve safety and efficacy of chemotherapy, as well as to reduce adverse reactions to a minimum, doses of active agents applied were changed in relation to previously employed schedules. Methods: Patients with histologically documented mCRC who have not previously received chemotherapy or had received adjuvant or neoadjuvant chemotherapy, which ended 6 months before capecitabin treatment (1000 mg/m2 per os from 2nd to 8th day of each cycle), irinotecan (175 mg/m2 every 2 weeks), plus bevacizumab (5 mg/kg i.v. every 2 weeks) were observed. Results: The study, conducted as a prospective one included 35 patients of both sexes. Overall response rate (ORR) of 28.6%, partial response (PR) of 28.6%, progressive disease (PD) of 28.6% and stable disease (SD) of 42.8% were found. Progression-free survival (PFS) of the patients analyzed was 11.3 months (95% CL: 9.1 - 12.9) while overall survival (OS) of the patients included was 25.2 months (95% CL: 17.4 - 28.4 months) and 117 adverse effects were recorded in 24 patients. Alopecia, nausea and vomiting, hemorrhage, hand-foot syndrome, diarrhea, abdominal pain, proteinuria, and hypertension (51.4%, 37.1%, 37.1%, 25.7%, 22.8%, 20.0%, 20.0% and 17.1%, respectively) were most frequently observed adverse effects. Conclusion(s): The results of this clinical trial support and recommend the use of bevacizumab plus capecitabin and irinotecan in the doses and schedule applied throughout this study as first-line treatment of mCRC patients.

The study tries to explain the influence of regional affiliation on employees’ perception of tourism policy in the sector of cultural tourism. The main aim is to explore whether there is a difference between regional affiliations of employees and employees’ perception of tourism policy in the sector of cultural tourism in Montenegro. The survey was conducted using the interviewing, and the main statistical procedures were factor analysis and multivariate analysis of variance. Research outcome is a significant difference between employees in the northern and the coastal region of Montenegro, in the employees’ perception of the importance of measures and activities of tourism policy in the sector of cultural tourism. However, that difference could not significantly influence tourism policymaking process and the quality of specific tourism policy, which is intended for development of cultural tourism in Montenegro. Most of the significant differences depend on measures and activities, which do not directly influence the growth and development of cultural tourism that way. The study is inspired by the Erasmus+ CULTURWB project.