is why many birds exploited positive wind assistance which occurred on intense migration nights. This implies that the seasonal wind regimes over the North Sea alter its migratory dynamics which is reflected in headings, timing and intensity of migration.

Test automation has been an acknowledged software engineering best practice for years. However, the topic involves more than the repeated execution of test cases that often comes first to mind. Simply running test cases using a unit testing framework is no longer enough for test automation to keep up with the ever-shorter release cycles driven by continuous deployment and technological innovations such as microservices and DevOps pipelines. Now test automation needs to rise to the next level by going beyond mere test execution.

Abstract Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic responses in cells which strive to adapt to the changed conditions. A failure to adapt to prolonged or severe hypoxia can trigger cell death. While some cell types, such as neurons, are highly vulnerable to hypoxia, cancer cells take advantage of a hypoxic environment to undergo tumour growth, angiogenesis and metastasis. Hypoxia‐induced processes trigger complex intercellular communication and there are now indications that extracellular vesicles (EVs) play a fundamental role in these processes. Recent developments in EV isolation and characterization methodology have increased the awareness of the importance of EV purity in functional and cargo studies. Cell death, a hallmark of severe hypoxia, is a known source of intracellular contaminants in isolated EVs. In this review, methodological aspects of studies investigating hypoxia‐induced EVs are critically evaluated. Key concerns and gaps in the current knowledge are highlighted and future directions for studies are set. To accelerate and advance research, an in‐depth analysis of the functions and cargo of hypoxic EVs, compared to normoxic EVs, is provided with the focus on the altered microRNA contents of the EVs.

Simple Summary In early-stage (cT1-2N0) oral cancer, occult lymph node metastases are present in 20–30% of patients. Accordingly, accurate staging of the clinically negative cervical nodal basin is warranted in these patients. Sentinel lymph node biopsy has proven to reliably stage the clinically negative cervical nodal basin in early-stage oral cancer. However, due to the limited resolution of conventional sentinel lymph node imaging, occult lymph node metastasis may be missed in particular circumstances. Therefore, technical developments are necessary to bring the diagnostic accuracy of sentinel lymph node biopsy, in early-stage oral cancer, to a higher level. This review evaluates novel sentinel lymph node imaging techniques for early-stage oral cancer, such as MR lymphography, CT lymphography, PET lymphoscintigraphy and contrast-enhanced lymphosonography. Their reported diagnostic accuracy is described and their relative merits, disadvantages and potential applications are outlined. Abstract Sentinel lymph node biopsy (SLNB) is a diagnostic staging procedure that aims to identify the first draining lymph node(s) from the primary tumor, the sentinel lymph nodes (SLN), as their histopathological status reflects the histopathological status of the rest of the nodal basin. The routine SLNB procedure consists of peritumoral injections with a technetium-99m [99mTc]-labelled radiotracer followed by lymphoscintigraphy and SPECT-CT imaging. Based on these imaging results, the identified SLNs are marked for surgical extirpation and are subjected to histopathological assessment. The routine SLNB procedure has proven to reliably stage the clinically negative neck in early-stage oral squamous cell carcinoma (OSCC). However, an infamous limitation arises in situations where SLNs are located in close vicinity of the tracer injection site. In these cases, the hotspot of the injection site can hide adjacent SLNs and hamper the discrimination between tracer injection site and SLNs (shine-through phenomenon). Therefore, technical developments are needed to bring the diagnostic accuracy of SLNB for early-stage OSCC to a higher level. This review evaluates novel SLNB imaging techniques for early-stage OSCC: MR lymphography, CT lymphography, PET lymphoscintigraphy and contrast-enhanced lymphosonography. Furthermore, their reported diagnostic accuracy is described and their relative merits, disadvantages and potential applications are outlined.

Abstract In the present work, an interferometric unsteady analysis of the thermogravitational technique was for the first time attempted in a paralelepipedic microcolumn using binary mixtures with negative Soret coefficients. In particular, water/ethanol and toluene/methanol were considered, as they have significantly different thermophysical properties and relaxation times. Experiments were run with different temperature gradients in order to understand their impact on the stability of separation. Experimental results were compared with theoretical ones, predicted by Fury-Jones-Onsager theory, and by OpenFOAM 3D numerical simulations. Correlations between the separation and the flow in the third dimension perpendicular to the thermal gradient of the thermogravitational microcolumn were analysed. Numerical simulations were also conducted in traditional cylindrical columns in order to compare the results with those previously reported. In these cases, the impact on separation stability was correlated with the azimuthal component of velocity. Thus, in both configurations, the disturbing convective current, always generated in the direction perpendicular to the thermal gradient applied, was shown to be vital for flow stability analysis.

We study numerical optimisation algorithms that use zeroth-order information to minimise time-varying geodesically-convex cost functions on Riemannian manifolds. In the Euclidean setting, zeroth-order algorithms have received a lot of attention in both the time-varying and time-invariant cases. However, the extension to Riemannian manifolds is much less developed. We focus on Hadamard manifolds, which are a special class of Riemannian manifolds with global nonpositive curvature that offer convenient grounds for the generalisation of convexity notions. Specifically, we derive bounds on the expected instantaneous tracking error, and we provide algorithm parameter values that minimise the algorithm's performance. Our results illustrate how the manifold geometry in terms of the sectional curvature affects these bounds. Additionally, we provide dynamic regret bounds for this online optimisation setting. To the best of our knowledge, these are the first regret bounds even for the Euclidean version of the problem. Lastly, via numerical simulations, we demonstrate the applicability of our algorithm on an online Karcher mean problem.

Abstract Nowadays, the population is rapidly ageing because of increasing life expectancy and decreasing birth rates. Thus, the purpose of this systematic review is to prepare a comprehensive overview which identifies the activities of daily living (ADLs) that are gradually reduced among patients with dementia, as well as explore the therapies applied in relation to dementia and how they effectively improve the quality of life (QoL) of patients and caregivers. Furthermore, we aim to summarise the ADL activities influenced by therapies and examine the treatment costs and care for patients so that recommendations for research and development (R&D) can be made to improve both the QoL of people with dementia and cost-saving measures. The research focuses on four selected neurodegenerative diseases: Alzheimer, Parkinson, vascular dementia, and amyotrophic lateral sclerosis. Therefore, the peer-reviewed English written articles from 2014 to 2019 were searched between September 1 and December 13, 2019. Twenty-seven papers were included in the analysis. The results show that essential assistance occurs in connection with activities: eating, drinking, dressing, bathing, personal hygiene, use of the toilet, and transport. By contrast, shopping or cleaning is not addressed as much. A lower ability to take care of oneself is connected with poor patient health and higher social care costs because the patient requires care from external sources, such as home aid or nurse visits. The challenge that remains is to shift new knowledge from scientific disciplines and connect it with the needs of patients to remove legitimate barriers and increase the acceptance of new solutions by popularisation. Additionally, regarding the burden on caregivers, it would be appropriate to promote this area of education and employment so that family members can use formal caregivers, ensuring them free time and much-needed rest.

Our basic objects will be compact, even-dimensional, locally symmetric Riemannian manifolds with strictly negative sectional curvature. The goal of the present paper is to investigate the prime geodesic theorems that are associated with this class of spaces. First, following classical Randol’s appraoch in the compact Riemann surface case, we improve the error term in the corresponding result. Second, we reduce the exponent in the newly acquired remainder by using the Gallagher–Koyama techniques. In particular, we improve DeGeorge’s bound Oxη, 2ρ − ρn ≤ η < 2ρ up to Ox2ρ−ρnlogx−1, and reduce the exponent 2ρ − ρn replacing it by 2ρ − ρ4n+14n2+1 outside a set of finite logarithmic measure. As usual, n denotes the dimension of the underlying locally symmetric space, and ρ is the half-sum of the positive roots. The obtained prime geodesic theorem coincides with the best known results proved for compact Riemann surfaces, hyperbolic three-manifolds, and real hyperbolic manifolds with cusps.

The purpose of this study was to examine the relationship between leg muscle power, balance, coordination, and shooting skills in soccer. Participants in this study used 89 soccer athletes with an age range of 15-18 years (M = 17.6; SD: 1.30). The research instrument used a coordination test (soccer wall volley test), balance test (modified bass test), leg muscle power (standing long jump test or broad jump), and shooting skills test. Data collection techniques, namely by measuring tests and measurements by the implementation procedure. Data analysis in this study was using Pearson correlation and regression analysis with the help of the IBM SPSS 24 application. The results showed that: 1) There was a relationship between leg muscle power and shooting ability using instep; 2) There is a relationship between balance and the ability to shoot using the instep; 3) There is a coordination relationship with the ability to shoot using the instep; and 4) There is a relationship between leg muscle power, balance, and coordination with the shooting ability using the instep. Recommendations for further research are suggested to involve other independent variables (X) that are relevant to this study, such as leg length, running speed, and angle of impact.

The establishment of the United Nations after World War II raised hopes of a new era of peace. This was over-optimistic. Between 1945 and 1992, there were 149 major wars, killing more than 23 million people. Recent developments in warfare have significantly heightened the dangers for children. During the last decade child war victims have included: 2 million killed; 4-5 million disabled; 12 million left homeless; more than 1 million orphaned or separated from their parents; some 10 million psychologically traumatized. Researches indicate that children do develop PTSD after experiencing very stressful, life-threatening events such as happen in war. Wars of 21st century are often guerrilla-type civil wars in which women and children are not only the main victims, but are deliberately targeted. Thousands are displaced both internally and across borders. Wars at the end of nineties of 20th century in the region of ex Yugoslavian countries brought all the cruelty of war vivid again on European ground. Population were exposed to death, threatened death, actual or threatened serious injury, or actual or threatened sexual violence. During the War in Bosnia and Herzegovina 1992-1995 there were about 100 000 people killed (20% woman and 3.5% children) and about 18 000 children were orphaned because of war. Children are not capable to regulate their emotions and hyper-arousal on their own. It depends of the way how their parents (caretaker) regulate her/his own emotions. During the war weak child's ego is paralyzed with intensive stimuli and floating anxiety, it does not manage to make constructive solution for traumatic experiences in such a short time. Mothers with small children are especially vulnerable group during the war time: they are supposed to take care about children and feel happiness, what is almost impossible Severe war experiences could cause depressive symptoms in mothers, what reduce their emotional disposability and could lead in different form of the child's neglecting. PTSD symptoms were lasting longer in children if their mothers have had functioning problems. Traumatization of mothers is connected with different behavior problems in their children. Wars are continuing all over the world and there is a continuity of researches about their consequences on children. Any programs that intend to mitigate the psychological effects of such trauma need to adopt a public health approach aimed at reaching many thousands.

This paper presents a combined subjective and objective evaluation of an application mixing interactive virtual reality (VR) experience with 360° storytelling. The hypothesis that the modern immersive archaeological VR application presenting cultural heritage from a submerged site would sustain high levels of presence, immersion, and general engagement was leveraged in the investigation of the user experience with both the subjective (questionnaires) and the objective (neurophysiological recording of the brain signals using electroencephalography (EEG)) evaluation methods. Participants rated the VR experience positively in the questionnaire scales for presence, immersion, and subjective judgement. High positive rating concerned also the psychological states linked to the experience (engagement, emotions, and the state of flow), and the experience was mostly free from difficulties linked to the accustomization to the VR technology (technology adoption to the head-mounted display and controllers, VR sickness). EEG results are in line with past studies examining brain responses to virtual experiences, while new results in the beta band suggest that EEG is a viable tool for future studies of presence and immersion in VR.

Magnesium has little resistance to corrosion and therefore its production and use are quite limited. The problem of corrosion associated with these alloys has been alleviated to some extent by the advantages obtained from fine coatings. An additional dense barrier against corrosion is created, using coatings obtained from sol-gel. As an alternative for Cr-based conversion coatings, rare-earth elements-based ones are been increasingly investigated for Mg and its alloys due to being eco-friendly. Because of chemical inertness, low friction, and high hardness, diamond-like carbon (DLC) coatings have exhibited the best protection for Mg and its alloys. In this review, we shed light on recent advancements in novel coatings for Mg alloys including hybrid, rare-earth conversion, composite polymeric (polymer composite is a multi-phase material in which reinforcing fillers are integrated with a polymer matrix), and DLC coatings.