: The chemistry of complex compounds containing imine ligands is attracting significant attention from research-ers today. In this work, complexes of selected transition metals (Cu, Co, Ni and Fe) with imines based on ninhydrin and amino acids methionine and cysteine were synthesized. FTIR and UV/VIS spectroscopy were used for structural characterization. Antioxidant activity of the complex was analyzed by the FRAP method. The synthesized compounds showed a significant reducing ability, ranging from 221.94 to 756.30 µmol/L. In vitro antimicrobial activity was tested on strains from the ATCC collection. Inhibitory activity against the tested microorganisms was recorded, and the zones of inhibition ranged from 10-24 mm. Preliminary research shows that these compounds have biological potency, but more detailed in vitro and in vivo studies are required for their use.

The aim of this work was to investigate the interaction of Imatinib mesylate with biological ions Cu(II), Co(II) and Ni(II) in ethanol/water solutions. Structures of synthesized complexes were characterized by spectroscopy methods. Stereo-microscopy was used for determination of morphological properties of obtained crystals. The results of IR spectroscopy showed that biogenic metal complexes with ImM were formed through the oxygen donors of mesylate ion. Changes of crystals colours and sizes of the parent ligand and complexes were clearly seen. Antimicrobial screening revealed a significant effect of Co(ImM)2 complex on the tested microorganisms. This complex also showed significant antioxidant activity compared to Ni(II) and Cu(II) complexes.

Ciprofloxacin, CFL is a drug that belongs to the second generation of fluoroquinolone antibiotics with a wide range of effects on Gram-positive and Gram-negative bacteria. The aim of this work was to investigate the interaction of CFL as ligand with divalent biological cations (Mn2+, Ni2+ and Co2+) in approximate physiological conditions. Synthesized complexes were characterized using FTIR and stereo-microscopy. Antimicrobial screening was performed on bacterial strains of Escherichia coli, Salmonella Enteritidis, Enterococcus faecalis and Staphylococcus aureus. The results of FTIR spectroscopy showed that the M(II) complexes with CFL were formed through the oxygen donors of the carboxyl and carbonyl group of the ligand. Stereo-microscopic characterization revealed the difference in color and size of crystals of the ligand and metal complexes. Antimicrobial screening has shown that CFL and complexes have almost similar antimicrobial activity against investigated bacterial strains.