In this paper we present study of metabolic control in children suffering from TYPE 1 Diabetes Mellitus (T1DM) who use insulin pump (IP) therapy, and who were treated at Paediatric Clinic in Sarajevo. In retrospective study we followed all T1DM patients with IP therapy introduced in the period from 1st March 2005 to 1st September 2008. We analyzed their age and sex structure, therapy before IP use, and the metabolic control of T1DM represented with glycosylated haemoglobin (HbA1c) value just before and 6 months after IP therapy introducing. The total number of observed patients was 39. There were 24 boys (61,5 %) and 15 girls (38,5 %) with the age range between 12,3 +/- 3,2 years. Most patients were from age group 8-14 years. In the same number of patients 17 (43,6 %) diabetes duration was less than 5 years and 5-10 years. Before IP introduction most patient 61,5 % use therapy with insulin analogues. Mean value of HbA1c before IP therapy introduction was 8,57+/-1,65 % and 6 months after IP therapy introduction HbA1c 7,53 +/- 0,81 % (p = 0,0009). There was significant reduction HbA1c values even 6 month after IP therapy introduced. Therapy with IP in children with diabetes was very efficient in achieving therapeutic goal of T1DM treatment (HbA1c<7,0 %) what will protect patients from appearance and progression of chronic micro vascular complications on eyes, kidneys and peripheral nerves.

Innocent heart murmurs are hearth murmurs that occur in patients with a normal heart structure. They do not represent a disease of the heart and vascular system, and should not be treated as such. Iron-deficiency anaemia often causes, along with other symptoms, systolic heart murmurs and tachycardia. It appears in children of all ages representing a most common haematological paediatric disease. To establish the influence of iron-deficiency anaemia on genesis of innocent murmurs and to compare auscultatory and phono-electrocardiographic findings in patients with anaemia and heart murmurs before and after iron therapy. The study includes 120 patients with innocent heart murmurs that have been auscultated at cardio-rheumatic outpatient department of Pediatric Clinic of the Clinical Center of the University of Sarajevo, during the period from 01/01/2004 to 31/12/2004. Further diagnostic procedure, i.e. laboratory tests, diagnosed iron-deficiency anaemia in 30/120 patients. These patients have been followed in this study. 22/30 patients had systolic murmur I/II intensity of Levin scale; 8/30 patients had II/VI systolic murmurs of intensity by Levin. The highest number of examinees had 0-1 years of age, and in this group the number of boys was higher than the number of girls (M: F = 12:4). During the auscultatory and phono-ECG examinations of murmurs, 6 patients had haemoglobin values less than 95 g/l, which corresponds to an average and severe type of anaemia. 24 patients had haemoglobin values between 95 and 110 g/l, which corresponds to benign type of anaemia. The most numerous were patients aged between 0 - 1 year (3 patients with hemoglobin value Hb < 95 g/l, 13 patients with hemoglobin value Hb 95-110 g/l). All patients were treated with iron medicaments. After three months, clinical and laboratory re-evaluation was performed and it has demonstrated that after iron therapy 24 patients had level of a haemoglobin Hb >110 g/l and 6 patients had haemoglobin levels between 95 and 110 g/l. By auscultatory and phono-ECG examinations, murmurs of a level of intensity I/II was registered in only one child, while in the other 29 patients there were not any registered heart murmurs. Diagnosis of anaemia in the paediatric population group delays definitive diagnosis of heart murmurs. Innocent murmurs in children with sideropenic anaemia occur as its consequence. After adequately conducted iron therapy, i.e. cured anaemia, heart murmurs were not auscultated.

In this paper we present the study of chemotherapy and radiotherapy treatment success in children suffering from Hodgkin's disease (HD) that were treated at Hematology-oncology Department of Pediatric Clinic in Sarajevo. In retrospective study we followed all patients with HD aged 0-15 who were diagnosed with and treated for HD at Pediatric Clinic in Sarajevo over the last 10 years (1st of January 1997 - 31st of December 2006). Until 2000 we used combination of chemotherapy and radiotherapy according to UKCCSG HD 9201 treatment protocol, and after the year 2000 protocol UKCCSG HD 2000 (ChlVPP / ABVD) was applied. The total number of the treated children 33. There were 17 boys (51,51 %) and 16 girls (48,49 %). In 10 patients (30,3 %) we found II A stage of HD, in 4 (12,1 %) II B stage of HD, in 6 children (18,8 %) stage III A, in 4 children (12,1 %) stage III B, in 4 children (12,1 %) stage IV A and in 5 (15,1 %) stage IV B. In 7 patients (21,2 %) relapse occurred, which demanded more aggressive chemotherapeutic treatment and radiotherapy too; while for 4 patients (12,1 %) in combination with bone marrow transplantation. Three patients (9,0 %) died. There are 30 children (91,0 %) who are alive and in either 1st or 2nd remission phase of HD. Secondary malignancies did not occur in any of the patients. Although many patients (58,1%) were diagnosed in an advanced stage of illness (III and IV) the results of HD therapy at Pediatric Clinic in Sarajevo are comparable to those in other European centers.