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Publikacije (47)

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Anđela Kovačević, Azemina Lakota, Lamija Kuka, E. Becic, Alisa Smajovic, L. G. Pokvic

Diagnosis of anemia is a time intensive and medically expensive procedure requiring a multitude of tests to establish a final diagnosis. Classification is an even more complex procedure that often takes years to complete thus delaying proper treatment and worsening the prognosis. This paper presents the application of machine learning, K-nearest neighbors (KNN), in order to diagnose and classify anemia. Monitoring parameters used as input for diagnosis were: age, sex, ferritin, transferrin, vitamin B12, erythrocyte count, iron, folic acid, hemoglobin, while the parameter relevant for classification was MCV. The results of the study indicate significant possibilities for the application of this system in the field of medical diagnostics.

Plant-derived products are frequently found as ingredients in cosmetics. However, the current data show non-neglectable skin sensitizing potential of these preparations suggesting an urgent need for data regarding their health safety profile. The aim of this study was to assess the skin sensitization potential of commercial essential oils by selected Lamiaceae species (Lavandula angustifolia, Melissa officinalis, Mentha longifolia, Thymus vulgaris, Salvia officinalis, and Rosmarinus officinalis) using a chemistry-based Direct Peptide Reactivity Assay (DPRA) in order to predict their potential allergic properties. In the DPRA assay, nucleophile-containing synthetic peptides (cysteine peptide and lysine peptide) were incubated with the test substance for 24 h. Depletion of the peptide in the reaction mixture was measured by high-pressure liquid chromatography (HPLC) using UV detection and the average peptide depletion data for cysteine and lysine was then calculated. Menthae longifoliae aetheroleum showed no or minimal reactivity with 4.48% cysteine depletion, Rosmarini aetheroleum and Salviae aetheroleum showed low reactivity with the 12.79% and 15.34% of cysteine depletion, respectively, while the other analyzed essential oils showed moderate reactivity with the cysteine depletion between 23.21 and 48.43%. According to DPRA predictive analysis, only Menthae longifoliae aetheroleum can be classified as negative, while all other essential oils may be classified as positive, thus having the potential to cause skin sensitization.

Benzophenone (BP) type UV filters are common environmental contaminants that are posing a growing health concern due to their increasing presence in water. Different studies have evidenced the presence of benzophenones (BP, BP-1, BP-2, BP-3, BP-4, BP-9, HPB) in several environmental matrices, indicating that conventional technologies of water treatment are not able to remove them. It has also been reported that these compounds could be associated with endocrine-disrupting activities, genotoxicity, and reproductive toxicity. This review focuses on the degradation kinetics and mechanisms of benzophenone-type UV filters and their degradation products (DPs) under UV and solar irradiation and in UV-based advanced oxidation processes (AOPs) such as UV/H2O2, UV/persulfate, and the Fenton process. The effects of various operating parameters, such as UV irradiation including initial concentrations of H2O2, persulfate, and Fe2+, on the degradation of tested benzophenones from aqueous matrices, and conditions that allow higher degradation rates to be achieved are presented. Application of nanoparticles such as TiO2, PbO/TiO2, and Sb2O3/TiO2 for the photocatalytic degradation of benzophenone-type UV filters was included in this review.

L. Šeho, H. Šutković, V. Tabak, S. Tahirović, A. Smajović, E. Becic, Amar Deumic, L. S. Becirovic et al.

Dž. Gojak, K. Gvožđar, Ž. Hećimović, A. Smajović, E. Becic, Amar Deumic, L. S. Becirovic, L. G. Pokvic et al.

A. Alagic, S. Alihodžić, Nejra Alispahić, E. Becic, A. Smajović, F. Becic, L. S. Becirovic, L. G. Pokvic et al.

A. Dautovic, B. Đondraš, F. Dervišbegović, A. Smajović, E. Becic, L. S. Becirovic, L. G. Pokvic, A. Badnjević

A. Rovcanin, S. Skopljak, S. Suleiman, A. Smajović, E. Becic, F. Becic, L. S. Becirovic, L. G. Pokvic et al.

B. Imamović, Irmela Ivazović, A. Alispahić, E. Becic, M. Dedić, Armina Dacić

Anti-aging cosmetics are often sought after in order to slow down the aging process. Free radicals are one of the main causes of skin aging, and therefore antioxidants are used in anti-aging cosmetics. The aim of this study was to investigate which method is the most suitable for determining the antioxidant capacity of these products. Having samples extracted, the antioxidant capacity of the extracts obtained was determined by the following spectrophotometric methods: DPPH, Folin-Ciocalteu, FRAP, the ABTS method and the ferroion chelation method with ferrosine. The antioxidant capacity of the samples varied depending on the extract type and the method used. DPPH and ferroion chelation measurements with ferrosine were carried out in the part of the spectrum where plant pigments absorb. These pigments are often found in anti-aging products affecting these methods measurement results. The Folin-Ciocalteu method is suitable for researching the antioxidant capacity of hydrophilic extracts, but not lipophilic ones, where turbidity and the formation of a gelled ring occur. The FRAP method revealed similar results for all the samples and proved to be less sensitive than the others. The ABTS method for both types of extracts has proven to be the most suitable and sensitive method for determining the antioxidant capacity of anti-aging products.

This paper shows the use of membrane filters in adsorption of solution of tetracycline hydrochloride on graphene materials. The adsorption process was monitored at different wavelengths, different pH values at certain time intervals. The absorbances of the solutions were measured by UV-Vis spectrophotometry at two wavelengths (275 nm and 356 nm), and three pH values (pH 4, pH 7 and pH 10) every 90 minutes for 6 hours of monitoring, with constant stirring in an ultrasonic bath. The results showed decrease in absorbance at both wavelength and in all three pH values which proved the adsorption of tetracycline hydrochloride on GO and rGO. The largest decrease in absorbance was 98.1%. The most suitable pH value for adsorption was pH 4. This paper used a unique approach to filtration through membrane filters, which in the future could lead to the development of membrane filters based on graphene materials.

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