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23. 9. 2022.
Hybrid immunity in immunocompromised patients with CLL after SARS-CoV-2 infection followed by booster mRNA vaccination
Patients with chronic lymphocytic leukemia (CLL) are immuno-compromised. 1 They are at high risk for developing severe COVID-19 2-4 and mount suboptimal immunity after messenger RNA (mRNA) vaccination, 5,6 but they have slightly con fl icting results regarding cellular immunity. 7,8 In a “ hybrid immunity ” setting, immune protection is in fl uenced by prior infection status and vaccination. Here, we studied humoral and cellular hybrid immunity in a