Effect of high-shear mixer head on optical properties and disintegration time of orodispersible films
Although solid oral dosage forms present majority of commonly prescribed drugs, some patients struggle with ingesting them (Awad et al., 2021). Amongst those, a very significant group is the pediatric population. On the other side, questions concerning dosage consistency arise when it comes to liquid oral preparations, particularly for suspensions (Gupta et al., 2021). To avoid the limitations of conventional oral dosage forms, orodispersible films (ODFs) were developed as a promising, patient-tailored therapeutic alternative. After the administration, ODFs are swallowed naturally with saliva, and there is no need for additional water (Yadav et al., 2021). Furthermore, in terms of the pediatric population, the product not only has to be easy to swallow, but it also has to be visually appealing. Therefore, a lot of attention is dedicated to the visual appearance of ODFs, including their color and transparency or opacity (Zamanian et al., 2021). One of the methods used to produce ODFs is the solvent casting of polymer solution/dispersion. The aim of our study was to determine whether high shear mixer heads have an influence on the optical characteristics and disintegration time of the obtained ODFs.