Efficiency Of Allopurinol On The Value Of HDL And LDL And The Value Of The Aterogenic Index In Hyperuricemic Patients
The subject of the study in this pharmacological-clinical paper was the effect of allopurinol on the values of HDL and LDL in hyperuricemic patients. The research sample included 40 clinically treated patients of both sexes (UKC Sarajevo and JU General Hospital "Abdulah Nakaš" Sarajevo) and various age groups, which according to the diagnosis of the disease were classified into several subgroups (gout, diabetics, patients with metabolic syndrome). In subjects with established gout diagnosis, who were on the treatment with statins and allopurinol, it was found that the value of uric acid decreased after three and six months of use of allopurinol (p <0.05). It was found that the values of LDL fraction were statistically significantly decreased after 3 and 6 months of therapy (p <0.05), while the HDL fraction decreased after 3 months of therapy, but maintained the same to the sixth month of therapy. Also, in the treatment with allopurinol, subjects with metabolic syndrome with severe heart disease (hypertension present), the mean values of uric acid statistically decreased significantly, the values of LDL fractions were statistically significantly increased (p <0.05), while the values of HDL fraction increased after 3 months of therapy, so that later this value remained constant.