IN-VITRO ANTIINFLAMMATORY AND ANTIOXIDANT ACTIVITY OF ROSUVASTATIN
Statins exhibit their pharmalogical effects by competitive inhibition trough binding with active sites of enzymes. Rosuvastatin, of all statines, has the most binding interactions with the enzyme, and being the most potent statin, it is presumed that the strength of enzyme binding directly influences its potency. Reduction of derivatives of mevalonic acids results with decreased risk of cardiovascular diseases and very significant pleotropic effect of statins. Rosuvastatin comes in the form of calcium salt. During the clinical trial it has been marked as superstatin with its proven activity in lowering cholesterol levels. Aim of this paper was to examine the antiinflammatory and antioxidant activity