Antimicrobial agents in laying hens

The European Union permitted 6 antimicrobial agents that can be used in laying hens. These are colistin, tyrosine, neomycin, oxytetracycline, chlortetracycline, and erythromycin. Antimicrobial drugs are used today primarily for the prevention and treatment of diseases in poultry and often (not in the EU) to stimulate growth. Because these drugs are often used irrationally, there are good chances that their residues will be found not only in poultry meat but also in the eggs within a certain period after the termination of treatment. In addition to the administration of authorised VMPs, the residues in eggs can be the result of erroneously applied medicated food, the contamination of the food with some antimicrobial drug in the mixing unit, as well as ?extra-label? use of drugs in poultry. The antimicrobial agents are distributed in the body and deposited in the eggs, mainly in the yolk where they persist longer than in the albumen. Drugs that are poorly absorbed from the gastrointestinal tract (aminoglycosides, aminocyclitols, polymyxins) cannot be detected in the eggs, while the residues of some antimicrobial drugs can be detected for up to two months (chloramphenicol) after the last treatment. The rational use of drugs in veterinary medicine has manifold significance. When using drugs only when they are really necessary (indicated), in the right dose and route of administration, the potential damage can be reduced and efficiency increased, while the risk of microorganism resistance development would be significantly decreased. All of this becomes more important when these drugs are used in food animals.