Summary: Recently, some studies indicate that paraneoplastic syndrome may be the first sign of lung cancer and may serve in early detection of cancer. Namely, during the last ten years, an increasing importance is given to hematological paraneoplastic syndrome of lung cancer. The aim of this study was to evaluate whether hemoglobin levels have paraneoplastic nature in patients diagnosed with lung cancer prior to any form of therapy, and to examine its relationships with platelet count. The study included 239 patients with lung cancer who were hospitalized at the Clinic for Pulmonary Diseases, Clinical Center of Sarajevo, during the period from January 2005 to December 2008, and a control group of 60 healty persons. The study did not include lung cancer patients with evident hemoptysis and patients who were under chemotherapy and/or were undergoing surgery. The results of our study have shown that the average hemoglobin for each histopathological type of lung cancer was significantly lower than the average hemoglobin in control group, except for large cell carcinoma. Lung cancers are classified according to the TNM classification. There were no significant differences in average hemoglobin between different stage of non small cell lung carcinoma as well as in average hemoglobin between limited and extended stage of small cell lung carcinoma. Our results also showed that there was a significant negative correlation between platelet count and hemoglobin levels. On the basis of our results we concluded that low hemoglobin in patients with lung cancer, with no evident hemoptysis, may have the character of paraneoplastic syndrome.

Recently, some studies indicate that paraneoplastic syndrome may be the first sign of lung cancer and may serve in early detection of cancer. Namely, during the last ten years, an increasing importance is given to hematological paraneoplastic syndrome of lung cancer. The aim of this study was to evaluate whether hemoglobin levels have paraneoplastic nature in patients diagnosed with lung cancer prior to any form of therapy, and to examine its relationships with platelet count. The study included 239 patients with lung cancer who were hospitalized at the Clinic for Pulmonary Diseases, Clinical Center of Sarajevo, during the period from January 2005 to December 2008, and a control group of 60 healty persons. The study did not include lung cancer patients with evident hemoptysis and patients who were under chemotherapy and/or were undergoing surgery. The results of our study have shown that the average hemoglobin for each histopathological type of lung cancer was significantly lower than the average hemoglobin in control group, except for large cell carcinoma. Lung cancers are classified according to the TNM classification. There were no significant differences in average hemoglobin between different stage of non small cell lung carcinoma as well as in average hemoglobin between limited and extended stage of small cell lung carcinoma. Our results also showed that there was a significant negative correlation between platelet count and hemoglobin levels. On the basis of our results we concluded that low hemoglobin in patients with lung cancer, with no evident hemoptysis, may have the character of paraneoplastic syndrome.

Atopic dermatitis is chronic, pruritic inflammatory skin disorder strongly influenced by environmental factors. Staplylococcus aurcus is the common pathogen and colonize the normal skin but it is not number of normal skin flora. Damaged protective skin function by atopic dermatitis, the disturbance of quantity and quality of lipids of stratum corneum are some of the reasons for increasing degree of skin colonisation with staphylococcus aureus. We had presented frequency of the isolation staphylococcus aureus from eczematous atopic skin, from the nose and throat of atopic patients and also from clinically unaffected atopic skin in the group of 30 children compared with 15 healthy children without positive atopic family history. Staphylococcus aureus had been significantly more isolated by all earlier mentioned places in atopic group of children. There is a direct correlation between intensity and also extensity of atopic dermatitis and frequency of the isolation of staphylococcus aureus from mentioned places. The role of staphylococcus aureus in pathogenesis of atopic dermatitis was discussed.

Psoriasis has well known characteristics of psychosomatic disease. The goals of this paper were to confirm next facts: 1. Whether has war psychotrauma had influences on number of new cases of psoriasis, and 2. The influence war psychotrauma as provoking factor on new patients suffering from psoriasis. The analysis was done on Dermatologic clinic in Sarajevo and was included only new cases of psoriasis from the 1st January 1992 to the 31th December 1995. This examination was done by inquiry. The inquiry was included two separate group of questions. One group was included so called peace time stress situations, for example: natural death some member of family, own disease or serious disease some member of family, problems with education of children, divorce, marriage and similar questions without direct connection and influence of war situation. The other group of questions were entirely connected with aggression on Bosnia and Herzegovina, and war condition, for example: killing or wounding some member of family or close to person, wounding inquiring person, separation from wife and/or children, and/or close to person; and many other situation which were consequences of aggression, like loosing of property or soldiering in army. Female had had the same answers on group of so called peacctime psychotrauma and war psachotrauma. However, male were shown the bigger sensibility on war psychotrauma. Namely, 68.7% of male were insisted on war psychotrauma as trigger moment on appear of psoriasis. Such investigations for studding impact of war psychotrauma as provoking factor of psoriasis in available literature, we haven't discovered.

In this paper the author presents the case of a girl with the typical Netherton's syndrome associated with herpes simplex recidivans. There was no relevans family history. In the first of life her skin appeared erythrodermic and diagnosis of atopic dermatitis was established. The bronchial asthma developed at age of four years. Total IgE and number of cosinofiles were elevated. The intradermal tests with pollen grass, house dust, eggs and milk were positive. Intradermal tests cellular immunity (PPD, Trichophytin) were negative. The number of T cells and B cells in the peripheral blood were normal, but NK cells were slightly decreased. Once or twice a year she suffers since 5 years of life exacerbation of herpes recidivas on her right site of the face. Microscopic examination of hairs revealed the typical appearance of trichorrhexis invaginata. Erythroderma persisted until the age of 12 years. Since then polycyclic and serpiginous lesions appeared.

The control of syphilis in Bosnia was organised and started by Professor Ernest Grin in 1948 and continued to the end of 1951. Regardless of the clinical picture, the treatment of endemic syphilis consisted of an oil suspension of penicillin with aluminium monostearate (PAM) 3.6 to 4.2 MIU for adults in six or seven intramuscular injections of 0.6 MIU every day or 1.2 MIU every other day. Today endemic syphilis in Yugoslavia is only historic fact.