The cement industry is under constant pressure to reduce its environmental footprint while ensuring economic competitiveness and technological reliability. One of the most effective strategies to achieve this goal is the substitution of traditional raw materials with alternative ones derived from industrial (by)products, waste, or secondary resources. This paper presents a structured methodology for the selection and evaluation of potential raw materials for clinker production. The proposed approach integrates four key criteria: physical compatibility, which determines whether the raw material can be handled by existing processing equipment; chemical compatibility, which ensures compliance with clinker quality requirements; environmental compliance, which assesses adherence to local and international environmental regulations; and economic viability, including the costs of material acquisition, processing, equipment adaptation, and CO2 emissions associated with the raw mix. The research procedure involves initial communication with suppliers, visual inspection of the material, laboratory analysis (chemical and environmental), raw mix modelling, and full economic evaluation. If at any stage the material fails to meet the required criteria, feedback is provided to the supplier, avoiding unnecessary costs and efforts. Results indicate that this integrated methodology offers a systematic and transparent making of decision framework that can accelerate the acceptance of alternative raw materials, improve resource efficiency, and contribute to sustainable cement production.