Karolinska Institute Stockholm
The blood–DRG barrier is composed of endothelial cells with high permeability and is monitored by a subset of CD163+ perivascular macrophages, a process that is arteriovenously zonated. Vascular monitoring is abrogated by interfering with caveolar transcytosis in endothelial cells or by depleting CD163+ macrophages.
In a recent study published in Nature Serger connected intermittent fasting (IF) to gut microbiome alterations and enhanced peripheral nerve regeneration following injury. 1 Fasting has been purported to have neuroregenerative effects, but the underlying mechanisms remained unclear. The authors found that IF-induced elevation of IPA (a microbiome-derived metabolite) promotes neutrophil in fi ltration into the dorsal root ganglia (DRG), which enhances the regeneration of sciatic nerve fi bers 1). 2 for
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