Background/Aim: Basal cell carcinoma (BCC) is the most common cancer of the skin. It is believed that increased UV radiation from the sun accounts for almost 90 % of the risk of BCC. There is a growing trend in the incidence of BCC in a younger population. The aim of study was to analyse the initial clinical symptoms of BCC that may be important for the early detection of this skin tumour. Method: The study was a prospective, multicentre study performed in the period from March 2017 to February 2022. A total of 69 respondents with BCC were analysed. Respondents applied for a targeted examination to examine a suspicious skin lesion (due to certain symptoms) or were diagnosed with BCC by accident, when examining other skin changes. Respondents were divided into 2 groups. The first, Group I (35 respondents), consisted of respondents with nodular BCC. The second, Group II (34 respondents), consisted of respondents with superficial spreading BCC. Initially, a careful history and data on the characteristics, shape and character of the tumour were taken from all respondents. Data on all (even the smallest) initial symptoms and relevant signs of evolution, as well as subjective problems related to the tumour were noted. All respondents underwent dermoscopy of suspected skin changes. Results: A significant difference was found between the examined groups in the characteristics of bleeding, crust formation and tendency to injury in lesions, where they occur more often in patients with nodular BCC. Symptoms such as burning and flaking occurred significantly more often in patients with superficial spreading BCC (p < 0.01), as well as the diameter of lesions over 5 mm (p < 0.05). Conclusion: Early clinical diagnosis of BCC is possible with a tumour diameter of only a few mm. The predominant initial (highly susceptible) symptoms of nodular BCC were initial bleeding and / or scab formation on the lesions, as well as propensity to injury. The superficial spreading form of BCC was often larger than 5 mm in diameter, with more frequent scaling of the lesion, as well as burning and stinging sensations in the tumour area. Itching was observed to be a very common previous occurrence in the BCC initial focus zone in subjects of both study groups. Dermsocopy is a highly reliable diagnostic method for early detection of BCC.

Leser-Trélat (LT) sign (syndrome) is a rare, distinctive clinical phenomenon that is manifested by a sudden, eruptive, appearance of multiple itchy seborrheic keratoses (SK) that sometimes coincide with occult malignancy. A 73-year-old patient came for examination of numerous, large seborrheic keratoses (SK) on the skin. According to the patient's statement, SK did not occur suddenly and "eruptively". Nevertheless, ultrasound and endoscopic evaluation were suggested to the patient to exclude the Leser-Trélat phenomenon. The patient was then diagnosed with an occult, asymptomatic rectal neoplasm. The occurrence of numerous seborrheic keratoses (especially if they are "eruptive", large and bizarre in shape), should raise suspicion of LT phenomenon, or internal malignancy in the patient, and result in relevant diagnostic procedures to detect possible latent malignancy. It would be wise for the doctors of all disciplines to be acquainted with the existence of the LT sign (syndrome) and possible clinical implications of it.

Background/Aim: Benign prostatic hyperplasia (BPH) is a very common disease in older men. BPH involves the presence of signs of hyperplasia of the stromal and epithelial elements in the prostate with consequent enlargement of its volume. The aim of this study is to analyse the frequency of typical complications in the treatment of patients with benign prostatic hyperplasia and the effect of medicamentous treatment. Method: Patients diagnosed BPH were included in the prospective, one-year study. They were divided into 2 groups. The first group (30 patients) consisted of those ones, whose prostate volume was equal to or over 50 cm 3 , while and the second group (30 patients) comprised the subjects with prostate volume less than 50 cm 3 . The complications of BHP analysed are residual urine (RU), symptomatic urinary infection, haematuria, thickening of the detrusor wall, diverticulum in the bladder, ureterohydronephrosis, renal failure, bladder stone and acute urinary retention (AUR). Results: The majority of patients in both groups were aged 60-69. There was a statistically significant difference in the average value of RU between the groups at the first, second and fifth check-ups (p < 0.05), as well as the complication of symptomatic urinary infection, since the same occurred earlier in the first group than in the second group (p < 0.05). There was no statistically significant difference in complications: haematuria, detrusor wall thickening and diverticulum (p > 0.05). Complications: ureterohydronephrosis, renal failure, bladder stone, and AUR were not diagnosed in patients in either group. Conclusion: Relevant medical therapy leads to a reduction of RU and reduces the risk of complications caused by its presence. Other complications of BPH were rare or absent in both groups, suggesting that appropriate and timely applied medical therapy affects the course of BPH and reduces the risk of complications and the need for surgical treatment. Benefit from medicamentous therapy is equally repre-sented in both analysed groups of patients.

Aim: The aim of this article is to determine the possible correlation between the smoking habit and the incidence of basocellular skin cancer (BCC). Patients and methods: The prospective study, which lasted from June 2012 to June 2018, included subjects diagnosed with basocellular skin cancer (BCC). Respondents were divided into 3 groups. The first, group A (21 respondents), are respondents who smoke 20-35 cigarettes a day. The second, group B (19 respondents), consists of respondents who smoke 35-50 cigarettes a day. The third, group C (91 respondents), consist of non-smokers. Observed parameters are sex, age, current and previous smoking habits, including duration (total smoking year) and intensity (average number of cigarettes smoked per day), age at the start of smoking, and prolonged exposure to the sun. Results: No statistically significant relationship was found between smoking and BCC frequency. It was shown that with BCC of the skin was more affected those who did not smoke. There is no clear relationship between the duration of smoking and/or the amount of smoking and the development of BCC, and it follows that this relationship is not likely to be causative. A suggestive, but not significant, evidence of relationship between smoking and skin cancer is found at this time. Conclusion: Since it is a conglomerate of possible etiological factors, further research is needed to definitively clarify the effect of tobacco consumption on the development of BCC by monitoring a larger number of respondents over a longer period of time in large prospective studies. In any case, a possible association with skin cancer is a reason to avoid smoking.