Introduction European treatment guidelines in persons with known coronary heart disease (CHD) focus on adherence to antiplatelet therapy, β-blockers, ACE/ARBs, and lipid-lowering agents, with goals for blood pressure (BP) of < 140/90 mm Hg and LDL cholesterol of < 3.0 mmol/l. Data on adherence to these measures in Eastern Europe are limited. Material and methods The Third Republic of Srpska, Bosnia and Herzegovina, Coronary Prevention Study (ROSCOPS III) was conducted in 2005–2006 at 10 primary heath care centres in 601 patients (36% female, mean age 55 years) with CHD including acute myocardial infarction or ischaemia, coronary artery bypass graft, or angioplasty who were examined and interviewed at least 6 months after the event. We examined the proportion of subjects on recommended treatments and at goal for BP, LDL-C, and non-smoking. Results The proportion of subjects on recommended treatments included 61% for β-blockers, 79% for ACE/ARBs, 63% for lipid-lowering agents and 74% for antiplatelet therapy. Only 30% of subjects were on all four of these treatments. 59% of subjects had BP at goal of < 140/90 mm Hg and 33% were controlled to < 130/80 mm Hg, 41% for LDL-C, and 88% were non-smokers. Improvements were seen in lipid-lowering and ACE/ARB drug use and non-smoking status from an earlier survey (ROSCOPS II) in 2002–2003. Conclusions Our data show, despite improvement over recent years, that many persons with CHD in the Republic of Srpska, Bosnia and Herzegovina are neither on recommended treatments nor at target for BP and/or LDL-C. Improved efforts targeted at both physicians and patients to address these issues are needed.

Patients who have survived myocardial infarction (MI), compared to the general population, have an increased risk of reinfarction, myocardial revascularization, and death. In this study we investigated the prognostic significance of the predictors of the risk for adverse coronary events in 118 patients, both male and female, with a confirmed diagnosis of MI in the last 3 years. The predictors of reinfarction, revascularization and death in patients who survived MI were: poor adherence to hypolipemics (hazard ratio [HR] 3.06, p=0.006), physical inactivity (HR 2.22, p=0.056), the number of variable risk factors (HR 1.29, p=0.025), and age (HR 1.06, p=0.007). After the inclusion of the invariable risk factors in the model of multivariant analysis, the following factors were singled out as significant predictors of the risk: gender (HR 3.86, p=0.0015), physical inactivity (HR 2.38, p=0.007), change in the level of triglycerides (HR 1.49, p=0.040), change in the number of variable risk factors (HR 1.41, p=0.0007), and age (HR 1.05, p=0.009). A 3-year follow-up of the patients who survived the first MI and who were enrolled in this study of secondary prevention demonstrated that physical inactivity, the number of variable risk factors and age significantly contributed to an increased risk of reinfarction, revascularization, and death.

» Sažetak. Pol, godine života, pušenje, arterijska hipertenzija, dijabetes melitus, dislipidemija i gojaznost su faktori rizika za nastanak kardioyaskularnih (KV) bolesti. Neki od njih su promjenljivi, а na neke se ne može uticati. Cilj rada je bio da se utvrdi prevalenca pojedinih faktora rizika kod osoba sa visokim rizikom za nastanak fatalnih KV dogadaja. Ispitanici su birani metodom slučajnog izbora, a na osnovu procjene KV rizika podijeljeni su и grupu sa visokim i grupu sa niskim rizikom za nastanak fatalnog KV dogadaja. Od pojedinih faktor rizika najzastupljeniji je bio povišena vrijednost ukupnog holesterola (90,48%), zatim LDL holesterola (80,95%), a zatim arterijska hipertenzija (76,19%). Neophodno je da se faktori rizika za KV bolesti kontinuirano prate i da se njihovom modifikacijom radi na prevenciji fatalnih KV dogadaja. Kod osoba sa manifestnom KV bolešću trebalo bi spriječiti napredovanje i récidivé bolesti, a kod asimptomatskih bi trebalo otkrivati faktore rizika i vršiti procjenu KV rizika i time spriječiti nastanak manifestnog oboljenja.