The clinical algorithm is a text format that is specially suited for presenting a sequence of clinical decisions, for teaching clinical decision making, and for guiding patient care. Clinical algorithms are compared as to their clinical usefulness with decision analysis. We have tried to make clinical algorithm for managing status epilepticus in children that can be applicable to our conditions. Most of the algorithms that are made on this subject include drugs and procedures that are not available at our hospital. We identified performance requirement, defined the set of problems to be solved as well as who would solve them, developed drafts in several versions and put them in the discussion with experts in this field. Algorithm was tested and revised and graphical acceptability was achieved. In the algorithm we tried to clearly define how the clinician should make the decision and to be provided with appropriate feedback. In one year period of experience in working we found this algorithm very useful in managing status epilepticus in children, as well as in teaching young doctors the specifities of algorithms and this specific issue. Their feedback is that they find that it provides the framework for facilitating thinking about clinical problems. Sometimes we hear objection that algorithms may not apply to a specific patient. This objection is based on misunderstanding how algorithms are used and should be corrected by a proper explanation of their use. We conclude that methods should be sought for writing clinical algorithms that represent expert consensus. A clinical algorithm can then be written for many areas of medical decision making that can be standardized. Medical practice would then be presented to students more effectively, accurately and understood better.

Vigabatrin has been in clinical use for 18 years. It has not been used widely in our country because of unavailability and costs of therapy. After the end of war in Bosnia and Herzegovina we started to use it in treatment of childhood epilepsies. We studied 19 patients that received vigabatrin as add on therapy and monotherapy. Follow up period was 6 months to 2 years. Nine of those patients were diagnosed as West syndrome, three had tuberous sclerosis, seven had intractable partial epilepsies. In the group with West syndrome 7 patients (5 as add on therapy and 2 as monotherapy) responded with complete control of seizures and disappearing of hypsarrhythmia in electroencephalographic recordings. One patient responded with reduction of seizures for 50%, one did not respond. In the group with tuberous sclerosis 1 was completely seizure free, one had reduction of seizures for 75%, one did not respond. Out of 7 patients with intractable partial epilepsies 3 responded with reduction of seizures between 75%-100%, 1 with reduction of seizures of 25%-50%, and 3 did not respond. Vigabatrin was well tolerated, we did not experience any serous adverse reactions. This antiepileptic drug can be a major improvement in treatment of some of the epileptic syndromes and needs further investigation.

Cerebral Palsy (CP) is a chronic disorder of motion and postural balance caused by defect or damage of immature brain. Possibility of primary prevention of CP is not big, the most important is early diagnosis. 120 newborns admitted to the Developmental department of Pediatric Clinic as "child at risk" were investigated. The average gestational age was 37.18 weeks, average birth weight was 2820.09 g. In the group of prematurely born children CP has developed in 15 out of 50 children (30%), in the group of term children it was present in 17 out of 57 children (29.83%). 32 children (29.92%) had birth weight below 2500 g. Among them there were 7 cases of CP (21.88%). Children with birth weight of over 2500 g (75 children, 70.09%) had CP in 25 cases (33.33%). There was no statistically significant difference between boys and girls, and between healthy and children with CP. There was high rate of correlation between gestational age, birth weight and score of neonatal optimality, as well as score of pregnancy optimality, score of delivery optimality and neonatal optimality. The important correlation appeared between score of delivery optimality and score of neonatal optimality. There was high correlation between score of perinatal optimality and all three of its components. Diagnosis of "child at risk" made only on the basis of risk factors during pregnancy, delivery and neonatal period is out of discussion, it is not pointing out the developmental outcome. Evaluation by the methods of clinical examination is necessary for prediction of neurological development.

: The clinical algorithm is a text format that is specially suited for presenting a sequence of clinical decisions, for teaching clinical decision making, and for guiding patient care. Clinical algorithms are compared as to their clinical usefulness with decision analysis. We have tried to make clinical algorithm for managing status epilepticus in children that can be applicable to our conditions. Most of the algorithms that are made on this subject include drugs and procedures that are not available at our hospital. We identified performance requirement, defined the set of problems to be solved as well as who would solve them, developed drafts in several versions and put them in the discussion with experts in this field. Algorithm was tested and revised and graphical acceptability was achieved. In the algorithm we tried to clearly define how the clinician should make the decision and to be provided with appropriate feedback. In one year period of experience in working we found this algorithm very useful in managing status epilepticus in children, as well as in teaching young doctors the specifities of algorithms and this specific issue. Their feedback is that they find that it provides the framework for facilitating thinking about clinical problems. Sometimes we hear objection that algorithms may not apply to a specific patient. This objection is based on misunderstanding how algorithms are used and should be corrected by a proper explanation of their use. We conclude that methods should be sought for writing clinical algorithms that represent expert consensus. A clinical algorithm can then be written for many areas of medical decision making that can be standardized. Medical practice would then be presented to students more effectively, accurately and understood better.

Congenital hemiparesis is defined as an unilateral disorder of movement and posture, with clinical signs of spasticity with flexor hypertonicity, increased tendon reflexes and characteristic posturing. We have examined a group of 26 children with congenital hemiparesis (14 boys and 12 girls) with mean age of 3.5 years (range 6 months to 9 years). 24 had been born at term (% weeks gestation) and 2 were preterm (% completed weeks gestation). From the neuroimaging point of view, congenital hemiparesis form a rather heterogeneous group. CT scans revealed: porencephalic cyst (6), unilateral ventricular enlargement (2), cortical atrophy with unilateral ventricular enlargement (1), hypodense zones resulting from previous hemathermous (4), normal CT scans (6), and 7 cases have not had CT scans for technical reasons (war conditions). Congenital hemiparesis mainly affects term children with prenatal origin in majority of cases. Vascular occlusions (in utero stroke) originating from various pathophysiological factors, maternal or fetal, may result in congenital hemiparesis. Normal CT findings should be revised by using MRI, which provides direct evidence of white matter lesions.