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Nebojsa Lasica, K. Arnautović, Tomita Tadanori, P. Vulekovic, D. Kozić

Glioblastomas presenting topographically at the cerebellopontine angle (CPA) are exceedingly rare. Given the specific anatomical considerations and their rarity, overall survival (OS) and management are not discussed in detail. The authors performed an integrative survival analysis of CPA glioblastomas. A literature search of PubMed, Scopus, and Web of Science databases was performed per PRISMA guidelines. Patient data including demographics, clinical features, neuroimaging, management, follow-up, and OS were extracted. The mean age was 39 ± 26.2 years. The mean OS was 8.9 months. Kaplan–Meier log-rank test and univariate Cox proportional-hazards model identified hydrocephalus (log-rank, p = 0.034; HR 0.34; 95% CI 0.12–0.94; p = 0.038), chemotherapy (log-rank, p < 0.005; HR 5.66; 95% CI 1.53–20.88; p = 0.009), and radiotherapy (log-rank, p < 0.0001; HR 12.01; 95% CI 3.44–41.89; p < 0.001) as factors influencing OS. Hydrocephalus (HR 3.57; 95% CI 1.07–11.1; p = 0.038) and no adjuvant radiotherapy (HR 0.12; 95% CI 0.02–0.59; p < 0.01) remained prognostic on multivariable analysis with fourfold and twofold higher risk for the time-related onset of death, respectively. This should be considered when assessing the risk-to-benefit ratio for patients undergoing surgery for CPA glioblastoma.

Vincent N. Nguyen, D. Gajski, K. Arnautović

Tuberculum sellae meningiomas represent 3% to 10% of all intracranial meningiomas and present with progressive visual deterioration secondary to optic apparatus compression. 1 Treatment options include open microsurgical or endoscopic endonasal approaches, with the size of the tumor, optic canal invasion, and the relationship to the surrounding neurovascular structures dictating the preferred approach. 2-10 Transcranial fronto-temporal skull base approaches offer excellent optic apparatus decompression, particularly when combined with anterior clinoidectomy and early sectioning of the falciform ligaments and release of the optic nerves. 2 - 4 , 11 - 14 We describe the case of a 57-year-old woman who presented to the senior author (KIA) with a large tuberculum sellae meningioma and signi fi cant optic apparatus compression causing a 2-month long worsening of vision that progressed to bilateral legal blindness for 2 weeks. The patient underwent a cranio-orbital pretemporal approach, 15 extradural anterior clinoidectomy, opening of falciform ligaments, release of optic nerve, and microsurgical resection of the tumor. To the best of our knowledge, this is the fi rst video case reporting on the reversal of bilateral preoperative blindness lasting 2 weeks preoperatively. The case presentation, surgical anatomy, operative nuances, and postoperative course with imaging are reviewed. The patient provided written informed consent for the publication of her image and PHI.

Jaafar Basma, Mallory R. Dacus, Rahul Kumar, D. Spencer, K. Arnautović

BACKGROUND: Questions remain regarding optic nerve (ON) physiology, mechanical compliance, and microvasculature, particularly surgical outcomes and atypical visual field defects associated with sellar/parasellar pathology (eg, tumors and aneurysms). OBJECTIVE: To study the microsurgical/histological anatomy of each ON segment and corresponding microvasculature, calculate area of optic-carotid space at each decompression stage, and measure ON tension before/after compression. METHODS: Five cadaveric heads (10 sides) underwent sequential dissection: (1) intradural (arachnoidal) ON dissection; (2) falciform ligament opening; (3) anterior clinoidectomy, optic canal decompression, and ON sheath release. At each step, we pulled the nerve superiorly/laterally with a force meter and measured maximal mobility/mechanical tension in each position. RESULTS: Cisternal ON microvasculature was more superficial and less dense vs the orbital segment. ON tension was significantly lower with higher mobility when manipulated superiorly vs lateromedially. Optic-carotid space significantly increased in size at each decompression stage and with ON mobilization both superiorly and laterally, but the increase was statistically significant in favor of upward mobilization. At decompression step, upward pull provided more space with less tension vs side pull. For upward pull, each step of decompression provided added space as did side pull. CONCLUSION: Opening the optic canal, falciform ligament, and arachnoid membrane decompresses the ON for safer manipulation and provided a wider optic-carotid surgical corridor to access sellar/parasellar pathology. When tailoring decompression, the ON should be manipulated superiorly rather than lateromedially, which may guide surgical technique, help prevent intraoperative visual deterioration, facilitate postoperative visual improvement, and help understand preoperative visual field deficits based on mechanical factors.

Harsh Deora, A. Raheja, Shashwat Mishra, V. Tandon, Edoardo Agosti, P. Veiceschi, K. Garg, V. Naik et al.

BACKGROUND During the COVID-19 pandemic, a multitude of surveys have analyzed the impact virus spreading on the everyday medical practice, including neurosurgery. However, none have examined the perceptions of neurosurgeons towards the pandemic, their life changes, and the strategies they implemented to be able to deal with their patients in such a difficult time. METHODS From April 2021 to May 2021 a modified Delphi method was used to construct, pilot, and refine the questionnaire focused on the evolution of global neurosurgical practice during the pandemic. This survey was distributed among 1000 neurosurgeons; the responses were then collected and critically analyzed. RESULTS Outpatient department practices changed with a rapid rise in teleservices. 63.9% of respondents reported that they have changed their OT practices to emergency cases with occasional elective cases. 40.0% of respondents and 47.9% of their family members reported to have suffered from COVID-19. 56.2% of the respondents reported having felt depressed in the last 1 year. 40.9% of respondents reported having faced financial difficulties. 80.6% of the respondents found online webinars to be a good source of learning. 47.8% of respondents tried to improve their neurosurgical knowledge while 31.6% spent the extra time in research activities. CONLCUSIONS Progressive increase in operative waiting lists, preferential use of telemedicine, reduction in tendency to complete stoppage of physical clinic services and drop in the use of PPE kits were evident. Respondents' age had an impact on how the clinical services and operative practices have evolved. Financial concerns overshadow mental health.

Mirza Pojskić, Vincent N. Nguyen, Andrew J. Gienapp, K. Arnautović

BACKGROUND Digital video recordings are increasingly used across various medical and surgical disciplines with advances in computer hardware and software technologies. The creation of high-quality surgical video footage requires a basic understanding of key technical considerations, together with creativity and sound aesthetic judgment. Online operative videos have become a core resource within neurosurgical education. OBJECTIVE To provide a step-by-step description for making operative videos using a video from a real case as an example. METHODS We recorded an operative video of the microsurgical resection of a right lateral ventricle subependymoma performed by an anterior interhemispheric transcallosal approach. The patient consented to surgical resection of the subependymoma and to publication of this operative video. With the video, we explain the step-by-step process the authors used for developing the raw video into a publishable surgical video. RESULTS The patient depicted in our video tolerated the surgery well and made a complete recovery. The final video produced from the surgery illustrated elements that Operative Neurosurgery, Neurosurgery, and other journals require in surgical videos. CONCLUSION Although more than 1200 peer-reviewed (PubMed) neurosurgical operative videos have been published so far, there has not been a single publication that describes the step-by-step process of producing an operative video. To the best of our knowledge, this is the first published detailed description of editing of an educational operative video in neurosurgery and the first video case report of a microsurgical resection of subependymoma of the lateral ventricle in the peer-reviewed English literature.

Paulo A S Kadri, K. Arnautović, Walid Ibn Essayed, O. Al-Mefty

Clival chordomas are rare malignant behaving tumors that grow, locally invade, metastasize, and seed, and they have a high recurrence rate.1,2 The longest disease control is achieved by radical resection followed by high doses of radiation therapy, commonly proton beam.3  To achieve radical tumor removal, multiple surgical procedures through different approaches might be required.4 Since the chordoma's origin is, and remains, extradural, an extradural approach is preferred, and can lead to intradural extension. Anterior approach is frequently utilized to remove the midline-located tumor and the eroded clivus.5  Several midline approaches were utilized, including the transbasal, transfacial, transcervical, open door, and Lefort's maxillotomies1; however, the same tumor removal can be achieved with a simple extension of the trans-sphenoidal approach, by resecting the anterior maxillary wall, of the contralateral to the lesion preponderant side.5 This approach coupled with the use of neuronavigation on mobile head and endoscopic-assisted technique allowed to achieve a wide and direct exposure, with the ability to resect extra- and intradural tumors.2,5 Lately, the endonasal endoscopic technique became popular as an alternative4; however, we found a great advantage in the ability to combine the stereoscopic microsurgical technique with the endoscopic dissection, in addition to avoiding the extensive nasal dissection and its complications.  We present a case of a 63-yr old woman with an upper clivus chordoma compressing the brainstem who underwent a gross total resection by endoscopic-assisted microscopic techniques through an anterior clivectomy approach. Patient consented to the procedure and publication of her images.

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