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Efficient communication is an integral part of everyday life and as such is important for the successful professional work of a pharmacist as a member of the medical personnel, foremost on the primary health care level. Nowadays, few studies of pharmaceutical practice in the field of communication in state pharmacies are focused on the communication from a pharmacist's point of view. Few studies have dealt with the analysis of the interactive process of communication and few studies have been directed at identifying essential factors necessary for measuring the communication in a pharmacy, or to the development of communication skills that both a pharmacist and a patient should develop in order to have more successful communication and improve their interpersonal relationship, providing more adequate health care services, which would lead to the re-professionalisation of pharmaceutical expertise in the healthcare system. Therefore, the aim of this paper is to identify the barriers in communication and ways to overcome them by reviewing the literature, with a particular emphasis on personal barriers of pharmacists in community pharmacies.

Dušanka M. Krajnović, Leontina Kerničan

History of Pharmacy Museum at the Faculty of Pharmacy University of Belgrade was founded in Belgrade in 1952, thanks to many pharmacists and historians, but especially to Mr Andrija Mirković (Mpharm). His precious private collection of antiquities, which he donated to the Faculty of Pharmacy in Belgrade, subsequently a basic one for the Museum foundation, included apothecary vessels, apparatuses, manuscripts and books dated back to the XVI century. Furthermore, there were included many other antiquities, books and manuscripts from pharmacies on the territory of former Yugoslavia, mostly from Serbia, so the entire Museum collection comprises various apothecary vessels: 700 ceramic, wooden, glass, porcelain and halide glass jars, as well as the XIX century exhibits from Pravitelstvena Apoteka (the first state-owned pharmacy in Serbia, which operated between 1836-1859). The Museum collection of accessories and vessels is completed with a library and precious archive materials. The library itself includes the original manuscripts as well as the colour offprint of some manuscripts, and printed works; mostly scientific books, textbooks, journals and pharmacopoeias with drug tax lists. Some printed books dating back to the Late Middle Ages are very rare and precious, such as Curio's Medicina Salernitana (1612) and the Ruel's version of Dioscorides' De materia medica. This entire collection is considered a unique one in Serbia for its variety and greatness, representing a precious source for studying the History of Pharmacy and Pharmaceutical Ethics (as a subject was included into the Faculty's curriculum since 1952 and cancelled recently in 2008).

Irena Mandić, Dušanka M. Krajnović

Thalidomide disaster was one of the biggest disasters in pharmaceutical industry. Since mid fifties of the twentieth century, more than 10.000 children have been born with stunted arms and legs, and damaged internal organs. Today, many questions sill stand: Was the tragedy preventable? What were the main reasons for borning more than 4.000 thalidomide children in West Germany, and 17 in United States? We tried to answer these questions, by comparing thalidomide stories in West Germany and United States. In West Germany, law regulations were very flexible. Federal Health Office registered new drugs, but had no authority to withdraw a drug that was approved dangerous on the market. Analyzing the stories he heard from his patients and colleagues, pediatrician dr. Widunkind Lenz realized that Contergan® (brand name for thalidomide) was responsible for birth defects. Pharmaceutical company, Chemie Grunenthal developed thalidomide, but re- fused to withdraw drug from the market. It took years, until the trial started. Dr. Lenz was dismissed from trial, as biased. As a result of two years long trial, company and federal government established the fund for children injured by Contergan®. In United States, pharmacologist dr. Frances Kelsey had been employed in Food and Drug Administration (FDA). She was the one who received a new drug application for thalidomide. Realized that application was in- complete, she refused to approve application. Unlike dr. Lenz, law regulations and FDA stood behind her. Thalidomide has never been approved in United States, and Dr. Kelsey was promotioned. She was also awarded for preventing thalidomide to reach the market. By comparing these stories, we realize how are important ethics and regulations in approving new drugs and their withdrawing.

Dušanka M. Krajnović, B. Perić, K. M. Kostadinovic

Branch Court Pharmacy (Filijalna Praviteljstvena apoteka) was operating in the city of Kragujevac (Serbia) during the short period from 1853 to 1859, as a state-run pharmacy. It was opened as a small affiliate pharmacy of the principal pharmacy in Belgrade and worked under its supervision. Nevertheless, it played a crucial role in the health protection and health care provision for the inhabitants of Kragujevac and its surroundings. Branch Court Pharmacy continued working under private ownership until the Second World War when it was nationalized and became a state-run pharmacy again.

Aleksandar Jovanović, Dušanka M. Krajnović

Almost 200 years have passed since the pure substance was first isolated, but scientists still face similar challenges. Quinine - the first chemotherapeutic agent in the treatment of malaria, is one of the good examples from history that testifies to the challenges in drug development. The aim of the paper was to present the history of the discovery and synthesis of quinine and its importance in medicine. Descriptive research was conducted using secondary data sources during September and October 2022. Quinine is one of the first active substance whose effectiveness has been proven in clinical research. Its widespread consumption soon led to a shortage of quinine, and new sources of this valuable active substance had to be provided. The challenges of plantation cultivation were solved by developing botany and its chemical synthesis through organic chemistry. By researching quinine, numerous pharmacologically active substances such as caffeine and methylene blue were found, which will start a revolution in the chemical industry and the industry of organic synthesis. With the development of resistance to antimalarials, quinine experienced its heyday again because it proved to be effective even in resistant strains. Quinine represents a significant historical discovery that influenced the development of many scientific disciplines, primarily pharmacy, medicine, and organic chemistry. The history of quinine provides us with an important historical lesson that we need to be aware of in today's time when the pharmacy is facing the significant challenges of developing new drugs. Acta Medica Medianae 2023;62(2):xx-xx.

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