Despite the fact that technology is improving day by day and that the medical devices (MDs) are being constantly upgraded, their malfunction is not a rare occurrence. The aim of this research is to develop an expert system that can predict whether the device will satisfy functional and safety requirements during a regular inspection. This expert system can be seen as part of Industry 4.0 that is revolutionizing medical device management. In order to develop the system, five machine learning algorithms that are representative of each classifier group, were used: (1) Random Forest, (2) Decision Tree, (3) Support Vector Machine, (4) Naive Bayes, (5) k-Nearest Neighbour. The Decision Tree outperformed other classifiers achieving the classification accuracy of 100% with and without attribute selection applied on the dataset. This study showed that machine learning algorithms can be used in order to predict MDs performance and potential failures in order to make the process of maintenance of medical devices more convenient and sophisticated and it is one step in modernizing medical device management systems by utilizing artificial intelligence.

Respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), are affecting a huge percentage of the world’s population with mortality rates exceeding those of lung cancer and breast cancer combined. The major challenge is the number of patients who are incorrectly diagnosed. To address this, we developed an expert diagnostic system that can differentiate among patients with asthma, COPD or a normal lung function based on measurements of lung function and information about patient’s symptoms. To develop accurate classification algorithms, data from 3657 patients were used and then independently verified using data from 1650 patients collected over a period of two years. Our results demonstrate that the expert diagnostic system can correctly identify patients with asthma and COPD with sensitivity of 96.45% and specificity of 98.71%. Additionally, 98.71% of the patients with a normal lung function were correctly classified, which contributed to a 49.23% decrease in demand for conducting additional tests, therefore decreasing financial cost.

The usage of Artificial Neural Networks (ANNs) for genome-enabled classifications and establishing genome-phenotype correlations have been investigated more extensively over the past few years. The reason for this is that ANNs are good approximates of complex functions, so classification can be performed without the need for explicitly defined input-output model. This engineering tool can be applied for optimization of existing methods for disease/syndrome classification. Cytogenetic and molecular analyses are the most frequent tests used in prenatal diagnostic for the early detection of Turner, Klinefelter, Patau, Edwards and Down syndrome. These procedures can be lengthy, repetitive; and often employ invasive techniques so a robust automated method for classifying and reporting prenatal diagnostics would greatly help the clinicians with their routine work. The database consisted of data collected from 2500 pregnant woman that came to the Institute of Gynecology, Infertility and Perinatology “Mehmedbasic” for routine antenatal care between January 2000 and December 2016. During first trimester all women were subject to screening test where values of maternal serum pregnancy-associated plasma protein A (PAPP-A) and free beta human chorionic gonadotropin (β-hCG) were measured. Also, fetal nuchal translucency thickness and the presence or absence of the nasal bone was observed using ultrasound. The architectures of linear feedforward and feedback neural networks were investigated for various training data distributions and number of neurons in hidden layer. Feedback neural network architecture out performed feedforward neural network architecture in predictive ability for all five aneuploidy prenatal syndrome classes. Feedforward neural network with 15 neurons in hidden layer achieved classification sensitivity of 92.00%. Classification sensitivity of feedback (Elman’s) neural network was 99.00%. Average accuracy of feedforward neural network was 89.6% and for feedback was 98.8%. The results presented in this paper prove that an expert diagnostic system based on neural networks can be efficiently used for classification of five aneuploidy syndromes, covered with this study, based on first trimester maternal serum screening data, ultrasonographic findings and patient demographics. Developed Expert System proved to be simple, robust, and powerful in properly classifying prenatal aneuploidy syndromes.