During the last decade the spreadsheets take very important place in many different kind of theoretical and practical applications. In recent years the PC-Windows Operating System allowed us to use and develop many sorts of specialised software packages, as well as expert packages, applicable in medicine. The relationship or communication between man and computer has been improved using new hardware configuration based on fast and intelligent processors, software modification and audio-visual technology. The facts mentioned above have instantly produced circumstances for more powerful spreadsheet software. According to powerful spreadsheet features we can utilise calculation and maximise HIGM requirement for our software configuration. The investigation within large area of Tuzla-Podrinje Kanton shows us that small number of people are using spreadsheet in medical application. Very small percentage of people have limited number of applications on calculation like, subtraction, addition, multiplication, division and percentage. They have often used spreadsheet as an integral part of the following software packages, EXCEL ver. 5.0 and very little Lotus 1-2-3 because Lotus is in these days behind. The aim of this paper is to highlight application of the spreadsheet USING EXCEL software package. Apart from simple calculation and graphic presentation in "DSS-Decision making support system" can be used for model simulation, generator configuration, management monitoring, support and decision making in health care.