1 Department of Anesthesiology and Pain Management, Stroger Hospital of Cook County, Chicago, Illinois, USA; 2 Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Banja Luka, Banja Luka, Bosnia and Herzegovina; 3 Department of Periodontology and Oral Medicine, Institute of Dentistry, Banja Luka, Bosnia and Herzegovina; 4 Department for Certification, The Republic of Srpska Agency for Certification, Accreditation and Quality Improvement in Health Care, Banja Luka, Bosnia and Herzegovina; 5 Department of Endodontic, Institute of Dentistry, Banja Luka, Bosnia and Herzegovina

Buerger’s disease (BD) is a relatively rare thrombotic, occlusive and non-atherosclerotic clinical syndrome of unknown etiology. In recent years, numerous epidemiological studies confirmed the strong association between chronic anaerobic periodontal infection and development of cardiovascular diseases, including BD. Therefore, the aim of this study is to clarify association between periodontal pathogens and Buerger’s disease. Confirmation of presence and identification of periopathogens in patients with BD can be considered crucial in developing novel therapies for BD. Further, periodontal therapy will lead to eventual improvement of BD patients’ condition.