The SI4CARE project is a transnational project which aims to develop both strategy and action plans to improve health and social care in the Adriatic–Ionian region. Starting from a survey of the status quo, each partner has developed some pilots to support the development and monitoring of the policy actions. In particular, partner number three, the Municipality of Miglierina, designed and developed a pilot related to the use of wearable devices for monitoring elderly patients in rural areas. With the collaboration of the complex unity of primary care (UCCP) of the Reventino area, the pilot is based on the use of smart wearable devices to monitor some parameters of older adults after their vaccinations for flu and covid. This paper focused on the design and implementation of the system. It describes its application in the Municipality of Miglierina. Presentation of the results and a discussion of the strengths and weaknesses will be presented, in detail, in future work. Finally, the possibility of extending the experiment to other Adriatic–Ionian regions is addressed.

Background Clinical guidelines recommend the identification of asthma comorbidities, especially treatable problems such as parental behaviours and child and parent anxiety. Purpose We aimed to (1) explore associations of asthma severity with child and parent state anxiety, trait anxiety, and asthma-related anxiety as well as with caregiver behaviours around physical activity and (2) explore if caregiver behaviours around physical activity were associated with use of inhaled β-Agonists when symptomatic, and with child and parent anxiety. Patients and methods Patients ages 3–17 years with asthma (n = 72) and their parents were recruited from the Pulmonology-Allergology Pediatric clinic University Hospital Centre Split in Split, Croatia during 2021. During a clinical visit, the pharmacological regimen was assessed and spirometry was performed. Children completed the State-Trait Anxiety Inventory for Children (STAI-C) and the Youth Asthma-Related Anxiety Scale (YASS). Parents completed the State-Trait Anxiety Inventory (STAI), the Parent Asthma-Related Anxiety Scale (PASS), and the Physical Activity Parenting Practices – Short Form (PAPP). Results Most patients had mild asthma (69.4%). Children with moderate to severe asthma had increased asthma-related anxiety (mean = 11.94 ± 6.1) compared with children with mild asthma (mean = 5.97 ± 6.39, p = 0.003). Parents of children with mild asthma reported behaviours allowing unsupervised physical activity outside more often when compared to parents of children with moderate or severe asthma. Physical activity facilitation parenting behaviour reduced the odds of a child's need for quick-reliever medication when symptomatic (OR = 0.376,95% CI = −1.885 to −0.072; p = 0.034); more coercive parenting increased the odds of a child's additional use of such medications (OR = 2.602; 95% CI = 0.005 to 1.908; p = 0.049). Parents of children in the highest quartile of trait anxiety showed less non-directive support (1.97 ± 1.01 vs. 2.89 ± 1.19, p = 0.031) and less autonomy support (3.14 ± 1.32 vs. 4.11 ± 1.23, p = 0.037) of physical activity in their children than those with less trait anxiety. Conclusion Asthma-related anxiety was an important construct in this sample of children, associated with their disease severity as well as their parent's behaviours around the child's physical activities. Current research, conducted during the COVID-19 pandemic, recognised the tangible ways that parents support or avoid the asthmatic children's physical activity participation. Child anxiety and recognised parental physical activity behaviours are potentially important factors to assess and target for intervention.

Slovenians like new technologies. However, they hold specific fears that robots will take their working places. Robots represent opportunities for providing service as the population grows old, and robots will be needed to help old people. Especially in fields where workers are scarce, such as healthcare, knowledge of the interaction human-cobot will be needed. Robots have been present in highly supervised and stable environments for decades. Due to extreme progress in robotics, they have moved among people, in less predictable environments, and have a more human-like appearance. The purpose of our paper is to present cases of cobots in Slovenian hospitals. We use qualitative methodology. Results of our desktop research are presented. Our paper researches contemporary management challenges in healthcare. Before, and after the COVID-19 pandemic, the demand for healthcare professionals was a critical challenge as the nursing staff was overburdened. It is hard to fill all the necessary nursing positions in hospitals. The problem seems to be getting even bigger due to the growing trend of the elderly population around the world. In the theoretical part, we present the interaction between human being-robot. In the empirical part, we present three examples of the incorporation of robots in hospitals in Slovenia and expose some of the current challenges, benefits, and difficulties of working with robots.

Vitamin D is a steroid hormone with numerous actions in the organism. There are strong evidences that relate vitamin D deficiency with liver lipid metabolism disturbances, but the mechanism of this action is still unknown. In our previous work we postulated the localization and accumulation of vitamin D receptor (VDR) in membrane of the lipid droplets (LDs) in hepatocytes. In this study, we applied the transmission electron microscopy (TEM) to confirm this hypothesis by using a long-term (6 months) high sucrose intake rat model that was previously found to be appropriate for research of the hepatic lipid accumulation. In addition to the VDR, we also found key vitamin D metabolizing enzymes, 1α-hydroxylase and CYP 24 associated with the membrane of the LDs. A light-microscopy data revealed significant increase in expression of VDR and CYP 24 in liver of high-sucrose treated rats, in comparison to controlones. According to the best of our knowledge, this is a first study confirming the presence of the VDR in the membrane of the LDs in general and also in particular in LDs of the hepatocytes that were accumulated as a consequence of the prolonged high sucrose intake. Moreover, we found association of main vitamin D metabolizing enzymes with LD membrane. These results provide a new insight in the possible relation of vitamin D signalling system with LD morphology and function and with the lipid metabolism in general.

Objective: The goal of our study was to assess the sensitivity and specificity as well as the positive and negative predictive value of bronchial brushing cytology (BBC) and imprint cytology, and their usefulness in the diagnosis of lung cancer using flexible bronchoscopy. Materials and methods: This study was conducted at the Department of Pathology, Cytology, and Forensic Medicine of the University Hospital Mostar. Data were collected from the archives for the period from January 2016 to December 2020. Data for 1936 patients were retrieved. A selection of 508 patients who had a histopathological and/or cytological confirmation of lung cancer were included in this study. Samples were obtained by flexible fiberoptic bronchoscopy. Brushing specimens were obtained with a sterile, single-use brush that was enclosed within a catheter sheath, and after that bronchial washing was performed. Tissue sampling techniques were performed using forceps endobronchial and transbronchial biopsies. The cytology and histopathology slides were viewed independently by three clinical cytologists and pathologists. Results : Using histopathological findings for lung cancer diagnosis we have found a significant degree of concordance between cytology and pathology ( κ = 0.135; P < 0.001). However, 107 patients were cytologically positive for lung cancer while being pathologically negative. Upon further investigation into their medical histories we found the following results: in 69 patients, lung cancer had already been suspected by some other method (radiological/CT imaging or atypical findings during bronchoscopy) and the cytological confirmation of malignant cells was sufficient to start surgical or oncological treatment of the patient, while 38 patients had false positive cytology reports. BBC had shown a specificity of 98.77 %, sensitivity of 83.3 %, positive predictive value of 93.5 %, and negative predictive value of 96.5 %. Imprint cytology had a specificity of 98.3 %, sensitivity of 96.5 %, positive predictive value of 94.8 %, and negative predictive value of 98.9 %. Conclusion: In our research BBC and imprint cytology were shown to be useful methods for the diagnosis of lung cancer, and should be considered in clinical centers where biopsy samples can only be obtained using non-guided flexible bronchoscopy or where endobronchial ultrasound bronchoscopy is not available.