ABSTRACT Introduction: Lung cancer is most common cause of cancer-related mortality worldwide. Non-small-cell lung carcinoma (NSCLC) is disease with very low 5-year relative survival rate. For patients with non-small cell lung cancer, roles of current treatments are to prolong survival time and to improve quality of life. Aim: The aim of the work was to compare values of Glasgow Prognostic Score (GPS) before application of the chemotherapy medication with response to chemotherapy and toxic side effects associated with chemotherapy in patients treated with cisplatin-etopozid (PE) and cisplatin-gemcitabin (PG) in stages IIIb and IV of NSCLC. Testing role of Glasgow Prognostic Score as a possible predictor of response to therapy and toxic side effects of chemotherapeutic protocol was another aim of this work. Patients and methods: This prospective study included 60 patients in stages IIIb or IV of NSCLC, with ECOG ≤ 2. The patients were divided in two groups. First group contained 30 patients treated with chemotherapeutic protocol using cisplatin-etopozid (PE), and the same number of patients in the second group were treated with cisplatin-gemcitabin (PG). Results: Glasgow Prognostic Score (GPS) evaluation before the chemotherapy inclusion showed values of 1 (43.30:53.30), then 2 (40.00:36.70) and the lowest 0 (16.70:10.00) which supports the pathological values of GPS in developed lung cancer, i.e. most patients had pathological GPS value in both protocols (83.30:90.00). Monitoring of toxic side effects and response to chemotherapy was done after each cycle of treatment. Discussion: Results of this study revealed importance of GPS in selection of patients for treatment with chemotherapy. Patients with lower values of GPS treated using PE chemotherapeutic protocol had weaker response to therapy. Conclusion: Coefficient of correlation for therapy response in both chemotherapeutic protocol, compared with values of GPS before treatment, were not statistically significant, therefore GPS cannot be considered as a predictor of therapeutic on chemotherapy.

Introduction: Chronic obstructive pulmonary disease (COPD) is a disorder characterized by maximal expiratory flow decrease and slow forced lung exhalation, which are significantly unchanged over several months. Subjects and Methods: Our study included 100 patients, 50 males and 50 females, diagnosed COPD who have been tested by functional lung tests: spirometry, body plethysmography and blood gas analysis. Patients have been analyzed at Clinic for pulmonary diseases and TBC, University Clinical Center Tuzla. All tests have been done at Department for Cardiorespiratory Diagnostics. Results: In this study have shown highly significant correlation among following parameters: FEV1 and VC, FEV1 and FEF 25, FEV1 and FEF75/25, FEV1 and FEF75, FEF25 and FEF75/25, FEF75 and FEF75/25. In males FEV1, VC and FEV1/VC have been significantly decreased comparing to females. Our results have shown no significant deference among spirometry, plethysmography and blood gas analysis parameters in male smokers with COPD comparing to female smokers. It has been found significant difference for pCO2 in male comparing to female nonsmokers. Conclusion: According to the results we recommend that all individuals having chronic cough, dyspnea and wheezing, and who are smokers or ex-smokers, aged >45 years, considering BMI, should be tested by spirometry.

Introduction: Asthma is a chronic inflammatory airway disease, with more present allergic component who cause disease. Pacient and Metods: In this study was included 35 patients who had been bronchial asthma whom was made total IgE determined by nefelometric metod and skin test by Prick metod. Subjects which had increased values of IgE, had been tested for fecal parasites . Subjects wich was positiv for scin allergens was tested for specific IgE on Hytec 288 instrument with ELISA metod. Results: Folowing resaults was obtained: 57.14% (20) of subjects had increased values of total IgE, while 42.86% (15) had normal total IgE. All patients with increased values of total IgE were tested negative for fecal parazites. Percent conform Prick tests and specific IgE was for house dust 54.55%, ragweed 53.85%, grass pollen 45.45%, Dermato-phagoides Pteronyssinus 43.75%, Pollen trees 25.00%. Conclusion and Discussion: Allergic bronchial asthma capture big percent in patients with bronchial asthma. The most frequent allergen was house dust.