Objective: The primary goal of this study was to determine the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid’s lymphocytes and their subpopulations between cancerous lung and healthy lung from the same patient. Methods: Mini-bronchoalveolar lavage was taken from 55 patients from lung with cancer and healthy lung. After laboratory processing and addition of CD4, CD8, CD27, CD28 and CD56 antibody, the material was analyzed by flow cytometer. Results from lung with cancer were compared to the ones from the healthy lung. The examined patients were the test and the control group at the same time. Results: CD27+28+ forms of CD4+ and CD8+ lymphocytes are more activated in the cancerous lung compared to healthy lung, while the CD27-28- forms are less activated in diseased lung. CD4+ forms of CD56+ lymphocytes are more activated in cancerous lung compared to the health lung, while the CD8+ forms are less activated in diseased lung. Conclusion: Immature helper and cytotoxic T lymphocyte response, as well as regulatory NK and NKT cell response are more activated in cancerous lung compared to the health lung of the same patient.

AIM To determinate the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid's lymphocytes and their subpopulations between non- and small cell lung cancer. Also, the differences of abundance of examined lymphocytes were compared between main clinical stages of lung cancer. METHODS Mini-bronchoalveolar lavate was taken from lungs of 55 patients with cancer. After laboratory processing and adding CD3, CD4, CD8, CD27, CD28 and CD56 antibody, the material was analysed by flow cytometer. Results of Mini-BAL for non- and small cell lung cancer were compared, as well as the different clinical stages of the disease. RESULTS Immature and regulatory forms of lymphocytes are more activated, while mature and activated forms are less activated in small cell lung cancer compared to non small type. With an increase of the clinical stage of disease, immunological reaction of T lymphocytes is better expressed because of increasing of abundance of immature and regulatory forms of different subpopulations of lymphocytes. CONCLUSION All components of local CD4+ and CD8+ T lymphocyte, as well as NK and NKT cells response were more activated in lungs with small cell lung cancer, and these reactions were more expressed with an increase in the clinical stage.

14502 Background: The oral fluoropyrimidine X (Xeloda®) has improved efficacy, safety and convenience compared with 5-FU/LV in MCRC [Van Cutsem et al. Br J Cancer 2004] and early-stage colon cancer...

In the paper are stated the data of ten years observations of the occurrences of the seroconversion in the patients at the dyalized treatment in the dyalized center in Tesanj. The seropositiveness to B and C hepatitis was 16.5%, what is the usual percentage for the local population. The serconversion to the positive C hepatitis occurred in one patient, and that in the first year of the dialyzed treatment, what remains the possibility the dyalizis began in the period of the incubation. The separation of the seropositive apparati for the dyalisisi from the rest made the sufficient organizational measure by the dyalized center.

Analyses of creatinema in the cases of global respiratory failure was performed in this paper. The patients with global respiratory failure treated in General Hospital in TeSanj have been followed. For all patients laboratory analyses have been performed on the admimtion and in the time of clinical status improvement, including creatinin level, K, Na, Hb, Htc, and blood gas analyses with mesurement of pO2 pCO2 pH, BE, saturation of the blood with oxgen, BE and HCO3-. Creatinine level have been considered in coleration of body mass index, and general nutritional status. The dinamic source of creatinine level in the blood have been followed, in relation of parameters of respiratory status. The statistical significance in relation of creatinine level with the respiratory status was registrated. With the improvement of respiratory status and laboratory analyses related to respiratory status, decrease of creatinin level was registrated. Because of that the therapy given to the patients with respiratory failure could influence on potassium level, the relation of creatinnemia and potassium level in the blood wasn't considered. The high creatinin level couldn't be explained with the initial renal failure, but as the sign of metbolic adaptation to hypoxemic and hypoxyc situation on the body. The registration of high creatinine level in the situations of global respiratory failure could be the guidelines for the choice of the antibiotics for these patients, mostly for potentially nephrotoxic antibiotics, like aminoglicosides, and theirs combinations. The decision and evaluation of benefit and toxicity of antibiotics for these situations could be easier.

Inhibitors of angiotensin converting enzyme (ACE inhibitors) have been introduced more than fifteen years ago into the treatment of hypertension, congestive heart failure, myocardial infarction and diabetic nephropathy. The therapeutic success is related to their action in reduction of plasma and tissue angiotensin II concentrations and potentiation of endogenous kinins. They are able to improve myocardium metabolic status, prevent cardiac hypertrophy, limit myocardial infarct size, and thus prevent heart failure. Since 1987 ACE inhibitors are introduced in the clinical practice in our clinic. We introduced the therapy with lisinopril (Lopril), in 70% of patients among 2855 patients that were admitted in Coronary Care Unit in 1997 and 1998. Lisinopril was introduced as soon as the patient was admitted, together with fibrinolitic, Heparin and Aspirin therapy. Since that time we noticed decrease in postinfarction heart failure in comparison to previous years. We recommend permanent therapy with a small doses of ACE inhibitors in patients with heart infarction.

Use of medical information in everyday practice has been described in this paper. Importance of systematic collection, analysis and use, including correct "data management" is noticed. Information system is formed of every noted information, not only in computing form. Use of databases allows us connection to many information, but rational use should allow us to select only these in number an quality which are necessary for decision making.

The data in computing programs could make two types of problems, functioning of medical equipment and analyses of medical datas. The first one is not use limiting problem. The troubles could be performed in calculation of pregnancy dates but the final calculation in up to medical practitioners. The former situation, analyses of medical datas, could be limited without complete and correct datas, mainly in analyses of life expectancy tables, and related fields.

This paper is a review of the patients with pulmonary thromboembolism hospitalized at General hospital in Teanj starting from the first case recorded in 1980 till now and 172 patients were subjects of this study. Thromboembolism was a direct cause of death in 43.7% (75 patients). Clinical and laboratory records, etiology, chest radiography, ECG data of 89 patients hospitalised and treated in the last five years were analyzed in detail. The most frequent symptoms were dyspnea and tachypnea, often accompanied with other symptoms (84.2%), chest pain (65.2%), cough (52.4%), tachycardia (40.5%), hemoptysis (25.8%). At 74% of patients with pulmonary thromboembolism a significant simultaneous increase of all examined enzymes, except CPK was found. Pulmonary insufficiency (global or partial) was found at 75% of patients. According to our results, in 57.2% of the subjects the pathologic changes on Radiography (infiltrates of the lung, with or without affection of the pleura and changed position of diaphragm) were found, and 70.9% had changes on the ECG.

Case record of patients with lung abscess treated by postural drainage is presented in this paper. In young man with multiple explosive injuries lung abscess was formed two months after injury. A postural drainage with parenteral application of antibiotics has been performed. The expectoration was painful. At the seventh day there was no temperature, ESR was described at the tenth day. The general status was becoming better. At the seventeenth day patient was discharged from Hospital. Rig imaging was shown nearly completely resolution of lung abscess. Postural drainage was effective because of favorable localisation of abscess near the large bronchus and basely part of the lung.

The essential characteristic on carcinoma of the lung are presented. With 100 patients with Ca bronche diagnosed by pathology, we evaluated the significance of the clinical manifestation of this disease. The most frequent symptoms are: cough (83%), pectoral pain (65%), dyspnoea (60%), temperature (57%), haemoptysis (29%). It is presented the etiopathogenesis of these symptoms. The significance of history and physical findings in forming a preliminary diagnosis is analysed. This in turn is the basis for the programming examinations and diagnostic procedures.

The functional parameters Raw, Rrs, FEV1, RV, FEF25 and FEF50 have been examined in 1000 patients with bronchial obstruction. Measurement of airway resistance is the precise examination for bronchial obstruction. For the routine clinical examination the interruptional measurement of Rrs is sufficient (correlation test + 0.56). Resistance may be measured indirectly by dynamic pulmonary volume testing (correlation FEV1: Raw = -0.55; FEF50: Raw = -0.63).