The expression of PCNA and EGFY in tumor cells of experimental hepatocellular carcinoma of liver and squamous cell carcinoma of stomach in rats
he expression of PCNA and EGFy in chemically induced hepatocellular carcinoma and souamous cell carcinoma cells from rats were observed with immunohistochemical techniques. The results showed that the carcinoma cells of both tumors revealed a positive immunoreaction to both factors. According to the amount of MC surrounding the tumor cell nests,the specimens could be divided into two groups:the group with abundant MC infiItration and the group with little or no MC infiItration. The PCNA positive cells in carcinoma cell nests of both groups were calculated respectively. It revealed that the amount of PCNA positive cells in the group with little or no MC was significantly more than that in the other group.The ratio between the 2 groups in liver carcinoma was approxirnately 3:1 and in stomach cancer it was 2:1.Anoverexpression of EGFY was observed in tumor tissues of both groups, but the amount of EGFγ positive cells in the group with little or no MC was much higher than that of the group with abundant MC.