CURRENT RESEARCH TOPICS IN PHARMACY: In silico Approaches for Drug Design and Discovery
results, muscleblind-like proteins, FAD-linked sulfhydryl oxidase ALR, and several phosphodiesterases might be targets [8]. BindingDB predicted targets for 1h and 3h. Cholinesterases were predicted to be target for 1h and 3h while PDE4A, Carbonic anhydrases and Steroidogenic factor-1 were predicted as targets for only 1h [8]. In order to further investigate the interaction of these compounds with predicted targets, we selected three targets, PDE4A, ALR and DUSP1, which were emerged in both or either in activity and target prediction results, and performed molecular docking analysis using SwissDock [12, 13]. According to our results, 1h, 3c and 3h might interact with selected proteins [8]. Our results anticipated new activities and targets for the 1h, 3c and 3h. PDE4A, DUSP1 and ALR could be important targets for these compounds, since PDE4A has been suggested as a therapeutic target for anxiety and central nervous system disorders [14]. DUSP1, as an oncogene, involves in several cellular processes, such as cell proliferation, differentiation, cell cycle arrest and apoptosis, by its involvement in MAPK signaling [15]. ALR is another important target, inhibition of ALR caused apoptosis in rat hepatocytes and human derived glioma cells [16, 17].