THE FIXED COMBINATION OF PERINDOPRIL/AMLODIPIN IN A THERAPY OF ARTERIAL HYPERTENSION AND ARTERIAL STIFFNESS: TWO WEEK STUDY RESULTS

Objective: To investigate the efficiency and safety of the fixed combination of perindopril/amlodipin in a treatment if grade I and grade II arterial hypertension and arterial stiffness values after only two weeks of treatment. Design and method: The open clinical prospective controlled study was designed. The study was designed for two weeks and two group were formed. The first group was comprised of arterial hypertension grade I patients and group 2 of arterial hypertension grade 2. The cardiovascular risk profile was notified for all patients. The peripheral and central blood pressure, pulse wave velocity, stroke volume, augmentation index, pulse pressure, heart rate, the reflection index were analyzed before and two weeks after treatment. For the grade I arterial hypertension the fixed combination of perindopril/amlodipin was used in a dose of 5 mg/5 mg, and for grade 2 arterial hypertension dosage was 10 mg/10 mg. Therapy was given as a single tablet advised to be taken in the evening. The average grade I hypertension values were 158/92mmHg, and for grade II the average value was 162/102mmHg. The average vascular age for grade I arterial hypertension was 4,5 years, and for grade II arterial hypertension the average vascular age was 8,5years. Results: Results obtained from this short study showed significant lowering of blood pressure and the improvement of arterial stiffness values and in the vascular age was detected as well in both group. The average values of arterial hypertension felt within normal range after treatment in a both groups after two weeks of therapy. Patient compliance and satisfaction was notified. There were no side effects. Conclusions: The fixed combination of perindopril/amlodipin in a dose of 5 mg/5 mg for grade I arterial hypertension and 10 mg/10 mg for grade II arterial hypertension was proven to be effective in all patients. No adverse events were observed. The compliance of patients was excellent and evening dose is more preferable than morning regime. The arterial stiffness values are not constant and permanent. They are rather flexible and arterial hypertension values major dependent. The lower arterial hypertension, the lower arterial stiffness and vasc ular age.