& Abstract Chronic nonbacterial prostatitis/chronic pelvic pain syndrome is unsatisfactorily defi ned
and insuffi ciently studied illness. Also, the treatment success is questionable and there- fore, this illness is a therapeutical problem for urologists - which medications are the best choice in treating this uncomfortable condition? Th is paper presents results of prospective, open, analytical, comparative study that was performed on patients with diagnosed chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Patients were divided into three groups and were treated with two medi- cations ciprofl oxacin (C), doxazosin (D) and combination of ciprofl oxacin + doxazosin (C+D). Th e eff ects were measured using symptom questionnaire for prostate illnesses of the National Institute for Health - USA (NIH-CPSI). During the basic evaluation, sum ranging from to was calculated for each patient. Th is number is called total sum NIH-CPSI (National Institutes of Health Chronic Prostatitis Symptom Index) of the ques- tionnaire, which generates the questions from to . Th e most signifi cant change occurred in C+D group where the total sum changed from - in the beginning to - at the end of the treatment (, (p<,)). Signifi cant changes were also found in D group where the change was , (p<,). At the end of the treatment no signifi cant change was registered in C group (p<,): p<, - signifi - cance threshold. Combination of ciprofl oxacin + doxazosin proved to be the best choice for treatment.