Obese patients with partially controlled asthma: Weight control shows more benefit in IgE low patients
The clinical value of eosinophils (Eo) in asthma has been shown, but asthma and obesity association remains unclear. Aim was to analyse the impact of normalising of body mass index (BMI) in obese asthma patients on sputum and blood Eo count and asthma control. 140 obese patients (age:49.94±1.68 years; M/F ratio:0.82, BMI:30.3±0.3) with partially controlled asthma and eosinophilia in sputum and blood were included. Patients were divided in IgE high (≥100 IU/ml) and IgE low ( Before diet, BMI, sputum and blood Eo, predicted forced expiratory volume in first second (FEV1%), Asthma Control Test (ACT) and Asthma Quality of Life Questionnaire(AQLQ) were similar between IgE high and IgE low patients. Sputum Eo count decreased only in IgE low patients (before vs . after diet: 6.8±1.7 vs . 1.2±0.3; p vs . high: FEV1%: 81.9±0.5 vs . 78.9±0.5; p 19: 42% vs . 11%; p vs . 2.3±0.4; p Decreasing of BMI in obese patients with partially controlled asthma improves response to IGK resulting in improved lung function, asthma control and quality of life, particularly in IgE low patients.