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Genetic susceptibility to myelin and axonal injury as measured by myelin water imaging and multi-shell diffusion in multiple sclerosis
Despite several large-scale genome-wide association studies (GWAS) have been performed in MS, to date no study explored the relationship between genetic risk factors for MS and the extent of myelin and axon damage in the brain of MS patients, as measured by advanced MRI techniques. Our results identify novel genetic loci that might be associated with myelin and axonal pathology in MS Patients.